Increasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life

Ageing affects several brain areas causing a decrease in cognitive abilities and memory. We find that increasing the endogenous potential of the hippocampus to generate new neurons throughout life rejuvenates learning and memory, indicating that neural reserves can be exploited during ageing to comp...

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Autores principales:	Gabriel Berdugo-Vega, Gonzalo Arias-Gil, Adrian López-Fernández, Benedetta Artegiani, Joanna M. Wasielewska, Chi-Chieh Lee, Michael T. Lippert, Gerd Kempermann, Kentaroh Takagaki, Federico Calegari
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/053faa42850e4fdca82723e9f3346693
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spelling	oai:doaj.org-article:053faa42850e4fdca82723e9f33466932021-12-02T15:34:11ZIncreasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life10.1038/s41467-019-14026-z2041-1723https://doaj.org/article/053faa42850e4fdca82723e9f33466932020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14026-zhttps://doaj.org/toc/2041-1723Ageing affects several brain areas causing a decrease in cognitive abilities and memory. We find that increasing the endogenous potential of the hippocampus to generate new neurons throughout life rejuvenates learning and memory, indicating that neural reserves can be exploited during ageing to compensate for age- or disease-related cognitive impairments.Gabriel Berdugo-VegaGonzalo Arias-GilAdrian López-FernándezBenedetta ArtegianiJoanna M. WasielewskaChi-Chieh LeeMichael T. LippertGerd KempermannKentaroh TakagakiFederico CalegariNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gabriel Berdugo-Vega Gonzalo Arias-Gil Adrian López-Fernández Benedetta Artegiani Joanna M. Wasielewska Chi-Chieh Lee Michael T. Lippert Gerd Kempermann Kentaroh Takagaki Federico Calegari Increasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life
description	Ageing affects several brain areas causing a decrease in cognitive abilities and memory. We find that increasing the endogenous potential of the hippocampus to generate new neurons throughout life rejuvenates learning and memory, indicating that neural reserves can be exploited during ageing to compensate for age- or disease-related cognitive impairments.
format	article
author	Gabriel Berdugo-Vega Gonzalo Arias-Gil Adrian López-Fernández Benedetta Artegiani Joanna M. Wasielewska Chi-Chieh Lee Michael T. Lippert Gerd Kempermann Kentaroh Takagaki Federico Calegari
author_facet	Gabriel Berdugo-Vega Gonzalo Arias-Gil Adrian López-Fernández Benedetta Artegiani Joanna M. Wasielewska Chi-Chieh Lee Michael T. Lippert Gerd Kempermann Kentaroh Takagaki Federico Calegari
author_sort	Gabriel Berdugo-Vega
title	Increasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life
title_short	Increasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life
title_full	Increasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life
title_fullStr	Increasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life
title_full_unstemmed	Increasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life
title_sort	increasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/053faa42850e4fdca82723e9f3346693
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Increasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life

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