Correlation of the 48bp VNTR locus of DRN4 gene with overweight/obesity (literature review)

Obesity is one of the five global health risks; it is a worldwide problem. Mortality of obesity is 2.6 million per year. Recently, obesity is considered as a neurobehavioural disorder with defects appetite control. The central dopamine system regulates eating behavior. The cause of obesity is the di...

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Autores principales:	E. A. Novikova, T. A. Bairova, L. V. Rychkova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2017
Materias:	drd4 overweight obesity dopamine dopamine 4 receptors vntr locus reward eating disorders Science Q
Acceso en línea:	https://doaj.org/article/0540a1bc19024a8fa0dea0e5f389d3b0
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spelling	oai:doaj.org-article:0540a1bc19024a8fa0dea0e5f389d3b02021-11-23T06:14:38ZCorrelation of the 48bp VNTR locus of DRN4 gene with overweight/obesity (literature review)2541-94202587-959610.12737/article_59e85bc95a4e77.95444674https://doaj.org/article/0540a1bc19024a8fa0dea0e5f389d3b02017-09-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/434https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Obesity is one of the five global health risks; it is a worldwide problem. Mortality of obesity is 2.6 million per year. Recently, obesity is considered as a neurobehavioural disorder with defects appetite control. The central dopamine system regulates eating behavior. The cause of obesity is the diminished dopaminergic neurotransmission, which provokes an increase of food stimulus that leads to an increasing of the body mass index (BM1). 1n this case, the main candidate genes will be genes of dopamine type 2 receptors: dopamine receptor D2 (DRD2), D3 (DRD), D4 (DRD4). The article focuses on the DRD4 gene. The latest literature data about the relationship of various polymorphic variants of the DRD4 gene with eating disorders, overweight and obesity are analyzed. 1t has been clarified, that the 48bp VNTR is the main and most significant polymorphism. One part of the researches shows a positive correlation of the tandem repeat VNTR DRN4 gene with overweight, obesity, eating disorders, including the DRD4-S and DRD4-L alleles. The other part denies the correlation of the tandem repeat VNTR DRN4 gene with these indicators. Perhaps the contradictions are due to differences in research design, as well as ethnic, gender and age differences in cohorts, and due to the fact, that in vitro changes do not always correspond to changes in vivo.E. A. NovikovaT. A. BairovaL. V. RychkovaScientific Сentre for Family Health and Human Reproduction Problemsarticledrd4overweightobesitydopaminedopamine 4 receptorsvntr locusrewardeating disordersScienceQRUActa Biomedica Scientifica, Vol 2, Iss 5(1), Pp 63-68 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	drd4 overweight obesity dopamine dopamine 4 receptors vntr locus reward eating disorders Science Q
spellingShingle	drd4 overweight obesity dopamine dopamine 4 receptors vntr locus reward eating disorders Science Q E. A. Novikova T. A. Bairova L. V. Rychkova Correlation of the 48bp VNTR locus of DRN4 gene with overweight/obesity (literature review)
description	Obesity is one of the five global health risks; it is a worldwide problem. Mortality of obesity is 2.6 million per year. Recently, obesity is considered as a neurobehavioural disorder with defects appetite control. The central dopamine system regulates eating behavior. The cause of obesity is the diminished dopaminergic neurotransmission, which provokes an increase of food stimulus that leads to an increasing of the body mass index (BM1). 1n this case, the main candidate genes will be genes of dopamine type 2 receptors: dopamine receptor D2 (DRD2), D3 (DRD), D4 (DRD4). The article focuses on the DRD4 gene. The latest literature data about the relationship of various polymorphic variants of the DRD4 gene with eating disorders, overweight and obesity are analyzed. 1t has been clarified, that the 48bp VNTR is the main and most significant polymorphism. One part of the researches shows a positive correlation of the tandem repeat VNTR DRN4 gene with overweight, obesity, eating disorders, including the DRD4-S and DRD4-L alleles. The other part denies the correlation of the tandem repeat VNTR DRN4 gene with these indicators. Perhaps the contradictions are due to differences in research design, as well as ethnic, gender and age differences in cohorts, and due to the fact, that in vitro changes do not always correspond to changes in vivo.
format	article
author	E. A. Novikova T. A. Bairova L. V. Rychkova
author_facet	E. A. Novikova T. A. Bairova L. V. Rychkova
author_sort	E. A. Novikova
title	Correlation of the 48bp VNTR locus of DRN4 gene with overweight/obesity (literature review)
title_short	Correlation of the 48bp VNTR locus of DRN4 gene with overweight/obesity (literature review)
title_full	Correlation of the 48bp VNTR locus of DRN4 gene with overweight/obesity (literature review)
title_fullStr	Correlation of the 48bp VNTR locus of DRN4 gene with overweight/obesity (literature review)
title_full_unstemmed	Correlation of the 48bp VNTR locus of DRN4 gene with overweight/obesity (literature review)
title_sort	correlation of the 48bp vntr locus of drn4 gene with overweight/obesity (literature review)
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2017
url	https://doaj.org/article/0540a1bc19024a8fa0dea0e5f389d3b0
work_keys_str_mv	AT eanovikova correlationofthe48bpvntrlocusofdrn4genewithoverweightobesityliteraturereview AT tabairova correlationofthe48bpvntrlocusofdrn4genewithoverweightobesityliteraturereview AT lvrychkova correlationofthe48bpvntrlocusofdrn4genewithoverweightobesityliteraturereview
_version_	1718416988011757568

Correlation of the 48bp VNTR locus of DRN4 gene with overweight/obesity (literature review)

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