Structural basis for the recognition of guide RNA and target DNA heteroduplex by Argonaute

Argonaute proteins are important in the silencing machinery with some regulatory RNAs. Here, the authors solve the structure of an argonaute protein in complex with both the guide RNA and target DNA and propose a mechanism for their recognition.

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Autores principales:	Tomohiro Miyoshi, Kosuke Ito, Ryo Murakami, Toshio Uchiumi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0546337e1548436bbd5fd7bc57a030cc
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spelling	oai:doaj.org-article:0546337e1548436bbd5fd7bc57a030cc2021-12-02T14:38:34ZStructural basis for the recognition of guide RNA and target DNA heteroduplex by Argonaute10.1038/ncomms118462041-1723https://doaj.org/article/0546337e1548436bbd5fd7bc57a030cc2016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11846https://doaj.org/toc/2041-1723Argonaute proteins are important in the silencing machinery with some regulatory RNAs. Here, the authors solve the structure of an argonaute protein in complex with both the guide RNA and target DNA and propose a mechanism for their recognition.Tomohiro MiyoshiKosuke ItoRyo MurakamiToshio UchiumiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tomohiro Miyoshi Kosuke Ito Ryo Murakami Toshio Uchiumi Structural basis for the recognition of guide RNA and target DNA heteroduplex by Argonaute
description	Argonaute proteins are important in the silencing machinery with some regulatory RNAs. Here, the authors solve the structure of an argonaute protein in complex with both the guide RNA and target DNA and propose a mechanism for their recognition.
format	article
author	Tomohiro Miyoshi Kosuke Ito Ryo Murakami Toshio Uchiumi
author_facet	Tomohiro Miyoshi Kosuke Ito Ryo Murakami Toshio Uchiumi
author_sort	Tomohiro Miyoshi
title	Structural basis for the recognition of guide RNA and target DNA heteroduplex by Argonaute
title_short	Structural basis for the recognition of guide RNA and target DNA heteroduplex by Argonaute
title_full	Structural basis for the recognition of guide RNA and target DNA heteroduplex by Argonaute
title_fullStr	Structural basis for the recognition of guide RNA and target DNA heteroduplex by Argonaute
title_full_unstemmed	Structural basis for the recognition of guide RNA and target DNA heteroduplex by Argonaute
title_sort	structural basis for the recognition of guide rna and target dna heteroduplex by argonaute
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/0546337e1548436bbd5fd7bc57a030cc
work_keys_str_mv	AT tomohiromiyoshi structuralbasisfortherecognitionofguidernaandtargetdnaheteroduplexbyargonaute AT kosukeito structuralbasisfortherecognitionofguidernaandtargetdnaheteroduplexbyargonaute AT ryomurakami structuralbasisfortherecognitionofguidernaandtargetdnaheteroduplexbyargonaute AT toshiouchiumi structuralbasisfortherecognitionofguidernaandtargetdnaheteroduplexbyargonaute
_version_	1718390932251869184

Structural basis for the recognition of guide RNA and target DNA heteroduplex by Argonaute

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