Nano metamaterials for ultrasensitive Terahertz biosensing

Abstract As a candidate for a rapid detection of biomaterials, terahertz (THz) spectroscopy system can be considered with some advantage in non-destructive, label-free, and non-contact manner. Because protein-ligand binding energy is in the THz range, especially, most important conformational inform...

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Autores principales:	Dong-Kyu Lee, Ji-Hun Kang, Junghoon Kwon, Jun-Seok Lee, Seok Lee, Deok Ha Woo, Jae Hun Kim, Chang-Seon Song, Q-Han Park, Minah Seo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/05492c9619954892a49da920362bc4eb
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spelling	oai:doaj.org-article:05492c9619954892a49da920362bc4eb2021-12-02T16:08:10ZNano metamaterials for ultrasensitive Terahertz biosensing10.1038/s41598-017-08508-72045-2322https://doaj.org/article/05492c9619954892a49da920362bc4eb2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08508-7https://doaj.org/toc/2045-2322Abstract As a candidate for a rapid detection of biomaterials, terahertz (THz) spectroscopy system can be considered with some advantage in non-destructive, label-free, and non-contact manner. Because protein-ligand binding energy is in the THz range, especially, most important conformational information in molecular interactions can be captured by THz electromagnetic wave. Based on the THz time-domain spectroscopy system, THz nano-metamaterial sensing chips were prepared for great enhancing of detection sensitivity. A metamaterial sensing chip was designed for increasing of absorption cross section of the target sample, related to the transmitted THz near field enhancement via the composition of metamaterial. The measured THz optical properties were then analyzed in terms of refractive index and absorption coefficient, and compared with simulation results. Also, virus quantification regarding various concentrations of the viruses was performed, showing a clear linearity. The proposed sensitive and selective THz detection method can provide abundant information of detected biomaterials to help deep understanding of fundamental optical characteristics of them, suggesting rapid diagnosis way especially useful for such dangerous and time-sensitive target biomaterials.Dong-Kyu LeeJi-Hun KangJunghoon KwonJun-Seok LeeSeok LeeDeok Ha WooJae Hun KimChang-Seon SongQ-Han ParkMinah SeoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dong-Kyu Lee Ji-Hun Kang Junghoon Kwon Jun-Seok Lee Seok Lee Deok Ha Woo Jae Hun Kim Chang-Seon Song Q-Han Park Minah Seo Nano metamaterials for ultrasensitive Terahertz biosensing
description	Abstract As a candidate for a rapid detection of biomaterials, terahertz (THz) spectroscopy system can be considered with some advantage in non-destructive, label-free, and non-contact manner. Because protein-ligand binding energy is in the THz range, especially, most important conformational information in molecular interactions can be captured by THz electromagnetic wave. Based on the THz time-domain spectroscopy system, THz nano-metamaterial sensing chips were prepared for great enhancing of detection sensitivity. A metamaterial sensing chip was designed for increasing of absorption cross section of the target sample, related to the transmitted THz near field enhancement via the composition of metamaterial. The measured THz optical properties were then analyzed in terms of refractive index and absorption coefficient, and compared with simulation results. Also, virus quantification regarding various concentrations of the viruses was performed, showing a clear linearity. The proposed sensitive and selective THz detection method can provide abundant information of detected biomaterials to help deep understanding of fundamental optical characteristics of them, suggesting rapid diagnosis way especially useful for such dangerous and time-sensitive target biomaterials.
format	article
author	Dong-Kyu Lee Ji-Hun Kang Junghoon Kwon Jun-Seok Lee Seok Lee Deok Ha Woo Jae Hun Kim Chang-Seon Song Q-Han Park Minah Seo
author_facet	Dong-Kyu Lee Ji-Hun Kang Junghoon Kwon Jun-Seok Lee Seok Lee Deok Ha Woo Jae Hun Kim Chang-Seon Song Q-Han Park Minah Seo
author_sort	Dong-Kyu Lee
title	Nano metamaterials for ultrasensitive Terahertz biosensing
title_short	Nano metamaterials for ultrasensitive Terahertz biosensing
title_full	Nano metamaterials for ultrasensitive Terahertz biosensing
title_fullStr	Nano metamaterials for ultrasensitive Terahertz biosensing
title_full_unstemmed	Nano metamaterials for ultrasensitive Terahertz biosensing
title_sort	nano metamaterials for ultrasensitive terahertz biosensing
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/05492c9619954892a49da920362bc4eb
work_keys_str_mv	AT dongkyulee nanometamaterialsforultrasensitiveterahertzbiosensing AT jihunkang nanometamaterialsforultrasensitiveterahertzbiosensing AT junghoonkwon nanometamaterialsforultrasensitiveterahertzbiosensing AT junseoklee nanometamaterialsforultrasensitiveterahertzbiosensing AT seoklee nanometamaterialsforultrasensitiveterahertzbiosensing AT deokhawoo nanometamaterialsforultrasensitiveterahertzbiosensing AT jaehunkim nanometamaterialsforultrasensitiveterahertzbiosensing AT changseonsong nanometamaterialsforultrasensitiveterahertzbiosensing AT qhanpark nanometamaterialsforultrasensitiveterahertzbiosensing AT minahseo nanometamaterialsforultrasensitiveterahertzbiosensing
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Nano metamaterials for ultrasensitive Terahertz biosensing

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