Association of early failure of arteriovenous fistula with mortality in hemodialysis patients

Abstract Arteriovenous fistula (AVF) is prone to early dysfunction and relates to poor outcome. However, little is known about the role of early AVF dysfunction as an independent risk factor for death in hemodialysis patients. A retrospective cohort study was performed using data of patients who und...

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Autores principales:	Yit-Sheung Yap, Wen-Che Chi, Cheng-Hao Lin, Yi-Chun Liu, Yi-Wen Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/05495a53b512467d86a3b0f42df90a4e
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spelling	oai:doaj.org-article:05495a53b512467d86a3b0f42df90a4e2021-12-02T13:30:11ZAssociation of early failure of arteriovenous fistula with mortality in hemodialysis patients10.1038/s41598-021-85267-62045-2322https://doaj.org/article/05495a53b512467d86a3b0f42df90a4e2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85267-6https://doaj.org/toc/2045-2322Abstract Arteriovenous fistula (AVF) is prone to early dysfunction and relates to poor outcome. However, little is known about the role of early AVF dysfunction as an independent risk factor for death in hemodialysis patients. A retrospective cohort study was performed using data of patients who underwent initial AVF surgery at a single institution. Demographic, clinical, biochemistry and AVF parameters were extracted from the electronic records, and the association between these variables and mortality was analyzed by Cox proportional hazards model. A total of 501 patients on hemodialysis (63.4 ± 12.7 years, 57.3% male) were included, and the median observation period was 3.66 years. In multivariate analysis, early failure of AVF (hazard ratio (95% confidence interval): 1.54 (1.06–2.24); p = 0.023) was associated with overall mortality but not cardiovascular mortality. Other identified predictors of overall mortality included older age, peripheral artery disease (PAD), cardiomegaly, higher white blood cell (WBC) count and corrected calcium level, and lower total cholesterol level, while predictors of cardiovascular mortality included older age, coronary artery disease (CAD), PAD and lower hemoglobin level. In conclusion, patients with early AVF failure were associated with increased risk of overall mortality.Yit-Sheung YapWen-Che ChiCheng-Hao LinYi-Chun LiuYi-Wen WuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yit-Sheung Yap Wen-Che Chi Cheng-Hao Lin Yi-Chun Liu Yi-Wen Wu Association of early failure of arteriovenous fistula with mortality in hemodialysis patients
description	Abstract Arteriovenous fistula (AVF) is prone to early dysfunction and relates to poor outcome. However, little is known about the role of early AVF dysfunction as an independent risk factor for death in hemodialysis patients. A retrospective cohort study was performed using data of patients who underwent initial AVF surgery at a single institution. Demographic, clinical, biochemistry and AVF parameters were extracted from the electronic records, and the association between these variables and mortality was analyzed by Cox proportional hazards model. A total of 501 patients on hemodialysis (63.4 ± 12.7 years, 57.3% male) were included, and the median observation period was 3.66 years. In multivariate analysis, early failure of AVF (hazard ratio (95% confidence interval): 1.54 (1.06–2.24); p = 0.023) was associated with overall mortality but not cardiovascular mortality. Other identified predictors of overall mortality included older age, peripheral artery disease (PAD), cardiomegaly, higher white blood cell (WBC) count and corrected calcium level, and lower total cholesterol level, while predictors of cardiovascular mortality included older age, coronary artery disease (CAD), PAD and lower hemoglobin level. In conclusion, patients with early AVF failure were associated with increased risk of overall mortality.
format	article
author	Yit-Sheung Yap Wen-Che Chi Cheng-Hao Lin Yi-Chun Liu Yi-Wen Wu
author_facet	Yit-Sheung Yap Wen-Che Chi Cheng-Hao Lin Yi-Chun Liu Yi-Wen Wu
author_sort	Yit-Sheung Yap
title	Association of early failure of arteriovenous fistula with mortality in hemodialysis patients
title_short	Association of early failure of arteriovenous fistula with mortality in hemodialysis patients
title_full	Association of early failure of arteriovenous fistula with mortality in hemodialysis patients
title_fullStr	Association of early failure of arteriovenous fistula with mortality in hemodialysis patients
title_full_unstemmed	Association of early failure of arteriovenous fistula with mortality in hemodialysis patients
title_sort	association of early failure of arteriovenous fistula with mortality in hemodialysis patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/05495a53b512467d86a3b0f42df90a4e
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Association of early failure of arteriovenous fistula with mortality in hemodialysis patients

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