The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells

The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells

TMPRSS2 is regulated by androgen receptor signalling in the prostate, however it is unclear if blocking this signalling is beneficial in the context of SARS-CoV-2 lung infection. Here the authors show that antiandrogen treatment downregulates TMPRSS2 in the lung and reduces viral entry and infection...

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Autores principales: D. A. Leach, A. Mohr, E. S. Giotis, E. Cil, A. M. Isac, L. L. Yates, W. S. Barclay, R. M. Zwacka, C. L. Bevan, G. N. Brooke
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/054d5eddfbac4f51bb25f10d584c7186
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spelling oai:doaj.org-article:054d5eddfbac4f51bb25f10d584c71862021-12-02T16:31:43ZThe antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells10.1038/s41467-021-24342-y2041-1723https://doaj.org/article/054d5eddfbac4f51bb25f10d584c71862021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24342-yhttps://doaj.org/toc/2041-1723TMPRSS2 is regulated by androgen receptor signalling in the prostate, however it is unclear if blocking this signalling is beneficial in the context of SARS-CoV-2 lung infection. Here the authors show that antiandrogen treatment downregulates TMPRSS2 in the lung and reduces viral entry and infection.D. A. LeachA. MohrE. S. GiotisE. CilA. M. IsacL. L. YatesW. S. BarclayR. M. ZwackaC. L. BevanG. N. BrookeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
D. A. Leach
A. Mohr
E. S. Giotis
E. Cil
A. M. Isac
L. L. Yates
W. S. Barclay
R. M. Zwacka
C. L. Bevan
G. N. Brooke
The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells
description TMPRSS2 is regulated by androgen receptor signalling in the prostate, however it is unclear if blocking this signalling is beneficial in the context of SARS-CoV-2 lung infection. Here the authors show that antiandrogen treatment downregulates TMPRSS2 in the lung and reduces viral entry and infection.
format article
author D. A. Leach
A. Mohr
E. S. Giotis
E. Cil
A. M. Isac
L. L. Yates
W. S. Barclay
R. M. Zwacka
C. L. Bevan
G. N. Brooke
author_facet D. A. Leach
A. Mohr
E. S. Giotis
E. Cil
A. M. Isac
L. L. Yates
W. S. Barclay
R. M. Zwacka
C. L. Bevan
G. N. Brooke
author_sort D. A. Leach
title The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells
title_short The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells
title_full The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells
title_fullStr The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells
title_full_unstemmed The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells
title_sort antiandrogen enzalutamide downregulates tmprss2 and reduces cellular entry of sars-cov-2 in human lung cells
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/054d5eddfbac4f51bb25f10d584c7186
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