Beyond cytoarchitectonics: the internal and external connectivity structure of the caudate nucleus.

While there is ample evidence on the functional and connectional differentiation of the caudate nucleus (CN), less is known about its potential microstructural subdivisions. However, this latter aspect is critical to the local information processing capabilities of the tissue. We applied diffusion M...

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Autores principales:	Sonja A Kotz, Alfred Anwander, Hubertus Axer, Thomas R Knösche
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/05530316110e4154b44b27bd70ebd7b5
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spelling	oai:doaj.org-article:05530316110e4154b44b27bd70ebd7b52021-11-18T09:02:35ZBeyond cytoarchitectonics: the internal and external connectivity structure of the caudate nucleus.1932-620310.1371/journal.pone.0070141https://doaj.org/article/05530316110e4154b44b27bd70ebd7b52013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23922939/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203While there is ample evidence on the functional and connectional differentiation of the caudate nucleus (CN), less is known about its potential microstructural subdivisions. However, this latter aspect is critical to the local information processing capabilities of the tissue. We applied diffusion MRI, a non-invasive in vivo method that has great potential for the exploration of the brain structure-behavior relationship, in order to characterize the local fiber structure in gray matter of the CN. We report novel evidence of a functionally meaningful structural tri-partition along the anterior-posterior axis of this region. The connectivity of the CN subregions is in line with connectivity evidence from earlier invasive studies in animal models. In addition, histological validation using polarized light imaging (PLI) confirms these results, corroborating the notion that cortico-subcortico-cortical loops involve microstructurally differentiated regions in the caudate nucleus. Methodologically speaking, the comparison with advanced analysis of diffusion MRI shows that diffusion tensor imaging (DTI) yields a simplified view of the CN fiber architecture which is refined by advanced high angular resolution imaging methods.Sonja A KotzAlfred AnwanderHubertus AxerThomas R KnöschePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 7, p e70141 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sonja A Kotz Alfred Anwander Hubertus Axer Thomas R Knösche Beyond cytoarchitectonics: the internal and external connectivity structure of the caudate nucleus.
description	While there is ample evidence on the functional and connectional differentiation of the caudate nucleus (CN), less is known about its potential microstructural subdivisions. However, this latter aspect is critical to the local information processing capabilities of the tissue. We applied diffusion MRI, a non-invasive in vivo method that has great potential for the exploration of the brain structure-behavior relationship, in order to characterize the local fiber structure in gray matter of the CN. We report novel evidence of a functionally meaningful structural tri-partition along the anterior-posterior axis of this region. The connectivity of the CN subregions is in line with connectivity evidence from earlier invasive studies in animal models. In addition, histological validation using polarized light imaging (PLI) confirms these results, corroborating the notion that cortico-subcortico-cortical loops involve microstructurally differentiated regions in the caudate nucleus. Methodologically speaking, the comparison with advanced analysis of diffusion MRI shows that diffusion tensor imaging (DTI) yields a simplified view of the CN fiber architecture which is refined by advanced high angular resolution imaging methods.
format	article
author	Sonja A Kotz Alfred Anwander Hubertus Axer Thomas R Knösche
author_facet	Sonja A Kotz Alfred Anwander Hubertus Axer Thomas R Knösche
author_sort	Sonja A Kotz
title	Beyond cytoarchitectonics: the internal and external connectivity structure of the caudate nucleus.
title_short	Beyond cytoarchitectonics: the internal and external connectivity structure of the caudate nucleus.
title_full	Beyond cytoarchitectonics: the internal and external connectivity structure of the caudate nucleus.
title_fullStr	Beyond cytoarchitectonics: the internal and external connectivity structure of the caudate nucleus.
title_full_unstemmed	Beyond cytoarchitectonics: the internal and external connectivity structure of the caudate nucleus.
title_sort	beyond cytoarchitectonics: the internal and external connectivity structure of the caudate nucleus.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/05530316110e4154b44b27bd70ebd7b5
work_keys_str_mv	AT sonjaakotz beyondcytoarchitectonicstheinternalandexternalconnectivitystructureofthecaudatenucleus AT alfredanwander beyondcytoarchitectonicstheinternalandexternalconnectivitystructureofthecaudatenucleus AT hubertusaxer beyondcytoarchitectonicstheinternalandexternalconnectivitystructureofthecaudatenucleus AT thomasrknosche beyondcytoarchitectonicstheinternalandexternalconnectivitystructureofthecaudatenucleus
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Beyond cytoarchitectonics: the internal and external connectivity structure of the caudate nucleus.

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