Asymptomatic secondary hyperparathyroidism can mimic sacroiliitis on computed tomography

Abstract Secondary hyperparathyroidism (sHPT) as a result of chronic kidney disease (CKD) is a common health problem and has been reported to manifest at the sacroiliac joints (SIJ). The aim of this investigation was to systematically assess sacroiliac joint changes in asymptomatic sHPT as detected...

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Autores principales:	Virginie Kreutzinger, Torsten Diekhoff, Lutz Liefeldt, Denis Poddubnyy, Kay Geert A. Hermann, Katharina Ziegeler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0555cc101e2a4bca9f64b23de415bfa6
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spelling	oai:doaj.org-article:0555cc101e2a4bca9f64b23de415bfa62021-12-02T14:28:14ZAsymptomatic secondary hyperparathyroidism can mimic sacroiliitis on computed tomography10.1038/s41598-021-83989-12045-2322https://doaj.org/article/0555cc101e2a4bca9f64b23de415bfa62021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83989-1https://doaj.org/toc/2045-2322Abstract Secondary hyperparathyroidism (sHPT) as a result of chronic kidney disease (CKD) is a common health problem and has been reported to manifest at the sacroiliac joints (SIJ). The aim of this investigation was to systematically assess sacroiliac joint changes in asymptomatic sHPT as detected by high-resolution CT. Included in this IRB-approved retrospective case–control study were 56 patients with asymptomatic sHPT as well as 259 matched controls without SIJ disease. Demographic data were retrieved from electronic patient records. High-resolution computed tomography datasets of all patients were subjected to a structured scoring, including erosions, sclerosis, osteophytes, joint space alterations and intraarticular calcifications. Chi2 tests were used to compare frequencies of lesions. Erosions were significantly more prevalent in patients with sHPT, and were found mainly in the ventral (28.6% vs. 13.9%; p = 0.016) and middle (17.9% vs. 7.7%; p = 0.040) iliac portions of the SIJ. Partial ankylosis was rare in both cohorts (3.6% vs. 5.0%; p > 0.999); complete ankylosis was not observed. Neither extent not prevalence of sclerosis or calcifications differed significantly between groups. Joint lesions reminiscent of sacroiliitis can be found in a substantial portion of asymptomatic patients with secondary hyperparathyroidism. Further investigations into the clinical significance of these findings are warranted.Virginie KreutzingerTorsten DiekhoffLutz LiefeldtDenis PoddubnyyKay Geert A. HermannKatharina ZiegelerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Virginie Kreutzinger Torsten Diekhoff Lutz Liefeldt Denis Poddubnyy Kay Geert A. Hermann Katharina Ziegeler Asymptomatic secondary hyperparathyroidism can mimic sacroiliitis on computed tomography
description	Abstract Secondary hyperparathyroidism (sHPT) as a result of chronic kidney disease (CKD) is a common health problem and has been reported to manifest at the sacroiliac joints (SIJ). The aim of this investigation was to systematically assess sacroiliac joint changes in asymptomatic sHPT as detected by high-resolution CT. Included in this IRB-approved retrospective case–control study were 56 patients with asymptomatic sHPT as well as 259 matched controls without SIJ disease. Demographic data were retrieved from electronic patient records. High-resolution computed tomography datasets of all patients were subjected to a structured scoring, including erosions, sclerosis, osteophytes, joint space alterations and intraarticular calcifications. Chi2 tests were used to compare frequencies of lesions. Erosions were significantly more prevalent in patients with sHPT, and were found mainly in the ventral (28.6% vs. 13.9%; p = 0.016) and middle (17.9% vs. 7.7%; p = 0.040) iliac portions of the SIJ. Partial ankylosis was rare in both cohorts (3.6% vs. 5.0%; p > 0.999); complete ankylosis was not observed. Neither extent not prevalence of sclerosis or calcifications differed significantly between groups. Joint lesions reminiscent of sacroiliitis can be found in a substantial portion of asymptomatic patients with secondary hyperparathyroidism. Further investigations into the clinical significance of these findings are warranted.
format	article
author	Virginie Kreutzinger Torsten Diekhoff Lutz Liefeldt Denis Poddubnyy Kay Geert A. Hermann Katharina Ziegeler
author_facet	Virginie Kreutzinger Torsten Diekhoff Lutz Liefeldt Denis Poddubnyy Kay Geert A. Hermann Katharina Ziegeler
author_sort	Virginie Kreutzinger
title	Asymptomatic secondary hyperparathyroidism can mimic sacroiliitis on computed tomography
title_short	Asymptomatic secondary hyperparathyroidism can mimic sacroiliitis on computed tomography
title_full	Asymptomatic secondary hyperparathyroidism can mimic sacroiliitis on computed tomography
title_fullStr	Asymptomatic secondary hyperparathyroidism can mimic sacroiliitis on computed tomography
title_full_unstemmed	Asymptomatic secondary hyperparathyroidism can mimic sacroiliitis on computed tomography
title_sort	asymptomatic secondary hyperparathyroidism can mimic sacroiliitis on computed tomography
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0555cc101e2a4bca9f64b23de415bfa6
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Asymptomatic secondary hyperparathyroidism can mimic sacroiliitis on computed tomography

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