CuO/NiO bimetallic nanocomposite: A facile DNA assisted synthetic approach and evaluation of bio efficacy

In this present work, a simple chemical co-precipitation method was used to synthesize deoxyribonucleic acid (DNA) capped CuO-NiO bimetallic nanocomposite. The morphology and structure related properties of the samples were analyzed using Energy Dispersive X-Ray Analysis, X-Ray Diffraction, Transmis...

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Autores principales:	Sona G. Krishnan, Deepak Nand, Seena Sivadas, Ahmed Alfarhan, Karnan Muthusamy
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Nanocomposites Capping agents DNA Antimicrobial Antioxidant Science (General) Q1-390
Acceso en línea:	https://doaj.org/article/055672ff7e2e48f089fbee95171eea3a
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spelling	oai:doaj.org-article:055672ff7e2e48f089fbee95171eea3a2021-12-02T04:59:31ZCuO/NiO bimetallic nanocomposite: A facile DNA assisted synthetic approach and evaluation of bio efficacy1018-364710.1016/j.jksus.2021.101718https://doaj.org/article/055672ff7e2e48f089fbee95171eea3a2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1018364721003803https://doaj.org/toc/1018-3647In this present work, a simple chemical co-precipitation method was used to synthesize deoxyribonucleic acid (DNA) capped CuO-NiO bimetallic nanocomposite. The morphology and structure related properties of the samples were analyzed using Energy Dispersive X-Ray Analysis, X-Ray Diffraction, Transmission Electron Microscopy and Scanning Electron Microscopy. Widely used Agar well diffusion method evaluated the antimicrobial activity of the sample. DPPH and FRAP assays were applied to test the antioxidant activity of the sample. Average crystallite size of 16.218 nm NiO and 15.871 nm CuO were confirmed within CuO- NiO bimetallic oxide nanoparticles by means of XRD technique. EDAX studies confirmed the purity of the sample. The grain size obtained from TEM studies matches with the XRD results. The free radical scavenging activity of sample was higher in lower concentrations, viz. 0.1, 1, 5 and 10 µg/ml of the sample and activity decreased after that. The IC50 value in FRAP assay shows the potential of this mixed metal oxide nanoparticle in radical scavenging. In agar well cut method, the sample showed moderate antibacterial activity against Mycobacterium smegmatis and Salmonella typhimurium. The results also showed that the CuO-NiO bimetallic nanoparticles are biologically compatible, environmentally benign and economical material having potential applications in biomedical industry.Sona G. KrishnanDeepak NandSeena SivadasAhmed AlfarhanKarnan MuthusamyElsevierarticleNanocompositesCapping agentsDNAAntimicrobialAntioxidantScience (General)Q1-390ENJournal of King Saud University: Science, Vol 34, Iss 1, Pp 101718- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Nanocomposites Capping agents DNA Antimicrobial Antioxidant Science (General) Q1-390
spellingShingle	Nanocomposites Capping agents DNA Antimicrobial Antioxidant Science (General) Q1-390 Sona G. Krishnan Deepak Nand Seena Sivadas Ahmed Alfarhan Karnan Muthusamy CuO/NiO bimetallic nanocomposite: A facile DNA assisted synthetic approach and evaluation of bio efficacy
description	In this present work, a simple chemical co-precipitation method was used to synthesize deoxyribonucleic acid (DNA) capped CuO-NiO bimetallic nanocomposite. The morphology and structure related properties of the samples were analyzed using Energy Dispersive X-Ray Analysis, X-Ray Diffraction, Transmission Electron Microscopy and Scanning Electron Microscopy. Widely used Agar well diffusion method evaluated the antimicrobial activity of the sample. DPPH and FRAP assays were applied to test the antioxidant activity of the sample. Average crystallite size of 16.218 nm NiO and 15.871 nm CuO were confirmed within CuO- NiO bimetallic oxide nanoparticles by means of XRD technique. EDAX studies confirmed the purity of the sample. The grain size obtained from TEM studies matches with the XRD results. The free radical scavenging activity of sample was higher in lower concentrations, viz. 0.1, 1, 5 and 10 µg/ml of the sample and activity decreased after that. The IC50 value in FRAP assay shows the potential of this mixed metal oxide nanoparticle in radical scavenging. In agar well cut method, the sample showed moderate antibacterial activity against Mycobacterium smegmatis and Salmonella typhimurium. The results also showed that the CuO-NiO bimetallic nanoparticles are biologically compatible, environmentally benign and economical material having potential applications in biomedical industry.
format	article
author	Sona G. Krishnan Deepak Nand Seena Sivadas Ahmed Alfarhan Karnan Muthusamy
author_facet	Sona G. Krishnan Deepak Nand Seena Sivadas Ahmed Alfarhan Karnan Muthusamy
author_sort	Sona G. Krishnan
title	CuO/NiO bimetallic nanocomposite: A facile DNA assisted synthetic approach and evaluation of bio efficacy
title_short	CuO/NiO bimetallic nanocomposite: A facile DNA assisted synthetic approach and evaluation of bio efficacy
title_full	CuO/NiO bimetallic nanocomposite: A facile DNA assisted synthetic approach and evaluation of bio efficacy
title_fullStr	CuO/NiO bimetallic nanocomposite: A facile DNA assisted synthetic approach and evaluation of bio efficacy
title_full_unstemmed	CuO/NiO bimetallic nanocomposite: A facile DNA assisted synthetic approach and evaluation of bio efficacy
title_sort	cuo/nio bimetallic nanocomposite: a facile dna assisted synthetic approach and evaluation of bio efficacy
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/055672ff7e2e48f089fbee95171eea3a
work_keys_str_mv	AT sonagkrishnan cuoniobimetallicnanocompositeafacilednaassistedsyntheticapproachandevaluationofbioefficacy AT deepaknand cuoniobimetallicnanocompositeafacilednaassistedsyntheticapproachandevaluationofbioefficacy AT seenasivadas cuoniobimetallicnanocompositeafacilednaassistedsyntheticapproachandevaluationofbioefficacy AT ahmedalfarhan cuoniobimetallicnanocompositeafacilednaassistedsyntheticapproachandevaluationofbioefficacy AT karnanmuthusamy cuoniobimetallicnanocompositeafacilednaassistedsyntheticapproachandevaluationofbioefficacy
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CuO/NiO bimetallic nanocomposite: A facile DNA assisted synthetic approach and evaluation of bio efficacy

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