αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin

Interaction of fibronectin with αv-class and α5β1 integrins results in formation of cell adhesion complexes, but the initial events (<120 s) remain unclear. Here, the authors show that αv-class integrins bind fibronectin faster than α5β1 integrins and subsequently signal to α5ß1 integrins to stre...

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Autores principales:	Mitasha Bharadwaj, Nico Strohmeyer, Georgina P. Colo, Jonne Helenius, Niko Beerenwinkel, Herbert B. Schiller, Reinhard Fässler, Daniel J. Müller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0557ebcfe7fa470f91d155b2b8778b92
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spelling	oai:doaj.org-article:0557ebcfe7fa470f91d155b2b8778b922021-12-02T14:42:19ZαV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin10.1038/ncomms143482041-1723https://doaj.org/article/0557ebcfe7fa470f91d155b2b8778b922017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14348https://doaj.org/toc/2041-1723Interaction of fibronectin with αv-class and α5β1 integrins results in formation of cell adhesion complexes, but the initial events (<120 s) remain unclear. Here, the authors show that αv-class integrins bind fibronectin faster than α5β1 integrins and subsequently signal to α5ß1 integrins to strengthen the adhesion.Mitasha BharadwajNico StrohmeyerGeorgina P. ColoJonne HeleniusNiko BeerenwinkelHerbert B. SchillerReinhard FässlerDaniel J. MüllerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mitasha Bharadwaj Nico Strohmeyer Georgina P. Colo Jonne Helenius Niko Beerenwinkel Herbert B. Schiller Reinhard Fässler Daniel J. Müller αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin
description	Interaction of fibronectin with αv-class and α5β1 integrins results in formation of cell adhesion complexes, but the initial events (<120 s) remain unclear. Here, the authors show that αv-class integrins bind fibronectin faster than α5β1 integrins and subsequently signal to α5ß1 integrins to strengthen the adhesion.
format	article
author	Mitasha Bharadwaj Nico Strohmeyer Georgina P. Colo Jonne Helenius Niko Beerenwinkel Herbert B. Schiller Reinhard Fässler Daniel J. Müller
author_facet	Mitasha Bharadwaj Nico Strohmeyer Georgina P. Colo Jonne Helenius Niko Beerenwinkel Herbert B. Schiller Reinhard Fässler Daniel J. Müller
author_sort	Mitasha Bharadwaj
title	αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin
title_short	αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin
title_full	αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin
title_fullStr	αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin
title_full_unstemmed	αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin
title_sort	αv-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0557ebcfe7fa470f91d155b2b8778b92
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αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin

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