MicroRNA-Related Strategies to Improve Cardiac Function in Heart Failure

Heart failure (HF) describes a group of manifestations caused by the failure of heart function as a pump that supports blood flow through the body. MicroRNAs (miRNAs), as one type of non-coding RNA molecule, have crucial roles in the etiology of HF. Accordingly, miRNAs related to HF may represent po...

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Autores principales:	Huatao Zhou, Weijie Tang, Jinfu Yang, Jun Peng, Jianjun Guo, Chengming Fan
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	heart failure non-coding RNA microRNA modification therapy Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/055991311c42465b999776bed7eead5d
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spelling	oai:doaj.org-article:055991311c42465b999776bed7eead5d2021-11-19T05:27:52ZMicroRNA-Related Strategies to Improve Cardiac Function in Heart Failure2297-055X10.3389/fcvm.2021.773083https://doaj.org/article/055991311c42465b999776bed7eead5d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.773083/fullhttps://doaj.org/toc/2297-055XHeart failure (HF) describes a group of manifestations caused by the failure of heart function as a pump that supports blood flow through the body. MicroRNAs (miRNAs), as one type of non-coding RNA molecule, have crucial roles in the etiology of HF. Accordingly, miRNAs related to HF may represent potential novel therapeutic targets. In this review, we first discuss the different roles of miRNAs in the development and diseases of the heart. We then outline commonly used miRNA chemical modifications and delivery systems. Further, we summarize the opportunities and challenges for HF-related miRNA therapeutics targets, and discuss the first clinical trial of an antisense drug (CDR132L) in patients with HF. Finally, we outline current and future challenges and potential new directions for miRNA-based therapeutics for HF.Huatao ZhouWeijie TangJinfu YangJinfu YangJun PengJianjun GuoChengming FanChengming FanChengming FanFrontiers Media S.A.articleheart failurenon-coding RNAmicroRNAmodificationtherapyDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	heart failure non-coding RNA microRNA modification therapy Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	heart failure non-coding RNA microRNA modification therapy Diseases of the circulatory (Cardiovascular) system RC666-701 Huatao Zhou Weijie Tang Jinfu Yang Jinfu Yang Jun Peng Jianjun Guo Chengming Fan Chengming Fan Chengming Fan MicroRNA-Related Strategies to Improve Cardiac Function in Heart Failure
description	Heart failure (HF) describes a group of manifestations caused by the failure of heart function as a pump that supports blood flow through the body. MicroRNAs (miRNAs), as one type of non-coding RNA molecule, have crucial roles in the etiology of HF. Accordingly, miRNAs related to HF may represent potential novel therapeutic targets. In this review, we first discuss the different roles of miRNAs in the development and diseases of the heart. We then outline commonly used miRNA chemical modifications and delivery systems. Further, we summarize the opportunities and challenges for HF-related miRNA therapeutics targets, and discuss the first clinical trial of an antisense drug (CDR132L) in patients with HF. Finally, we outline current and future challenges and potential new directions for miRNA-based therapeutics for HF.
format	article
author	Huatao Zhou Weijie Tang Jinfu Yang Jinfu Yang Jun Peng Jianjun Guo Chengming Fan Chengming Fan Chengming Fan
author_facet	Huatao Zhou Weijie Tang Jinfu Yang Jinfu Yang Jun Peng Jianjun Guo Chengming Fan Chengming Fan Chengming Fan
author_sort	Huatao Zhou
title	MicroRNA-Related Strategies to Improve Cardiac Function in Heart Failure
title_short	MicroRNA-Related Strategies to Improve Cardiac Function in Heart Failure
title_full	MicroRNA-Related Strategies to Improve Cardiac Function in Heart Failure
title_fullStr	MicroRNA-Related Strategies to Improve Cardiac Function in Heart Failure
title_full_unstemmed	MicroRNA-Related Strategies to Improve Cardiac Function in Heart Failure
title_sort	microrna-related strategies to improve cardiac function in heart failure
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/055991311c42465b999776bed7eead5d
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MicroRNA-Related Strategies to Improve Cardiac Function in Heart Failure

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