Proof of Concept for Ozone-Based Disinfection of Heater Cooler Units

Heater Cooler Units (HCUs) are frequently used not only during heart surgery but also in ECMO therapy to regulate the blood temperature of patients. It is known from cardiac surgery that the water circuits of HCUs can be bacterially contaminated and under adverse conditions can lead to a nosocomial...

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Autores principales:	Markus Bongert, Jan Wüst, Justus Strauch, Dirk Buchwald
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2020
Materias:	heater cooler unit disinfection ozone ecmo mycobacterium chimaera computational fluid dynamics experimental rig “o3desi” Medicine R
Acceso en línea:	https://doaj.org/article/055aaa9dd2cb411ea3e332ea2814e218
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spelling	oai:doaj.org-article:055aaa9dd2cb411ea3e332ea2814e2182021-12-05T14:10:42ZProof of Concept for Ozone-Based Disinfection of Heater Cooler Units2364-550410.1515/cdbme-2020-3074https://doaj.org/article/055aaa9dd2cb411ea3e332ea2814e2182020-09-01T00:00:00Zhttps://doi.org/10.1515/cdbme-2020-3074https://doaj.org/toc/2364-5504Heater Cooler Units (HCUs) are frequently used not only during heart surgery but also in ECMO therapy to regulate the blood temperature of patients. It is known from cardiac surgery that the water circuits of HCUs can be bacterially contaminated and under adverse conditions can lead to a nosocomial infection of the patient. The addition of chemical disinfectants to the water of HCUs is problematic. In addition, it is an increasingly significant cost factor due to the required material and personnel input. The aim of this research project is both the development of an automated device for disinfecting water in HCUs and proof of its effectiveness. The device is based on ozone, a substance with known antimicrobial properties. To prevent ozone from coming into contact with the HCU components, the water is irradiated with UV light (254nm). Two bypasses and ozone sensors guarantee a complete elimination of residual ozone. The effectiveness of the device was tested by series of experiments with the surrogate germ, Pseudomonas aeruginosa. The device allows a wide range of ozone concentrations and exposure times to be selected. In previous test series, it has been shown both that a reduction of the bacterial count to drinking water quality can be achieved with a treatment time of only one hour, and that self-cleaning can be carried out effectively before clinical use, and in standby mode. Attention must be paid to the water quality in HCUs as a potential source of infection, regardless of where they are used. The "proof of concept" showed an excellent disinfection effect with simultaneous elimination of excess ozone to drinking water levels. The number of indicator bacteria in the water tank of the dummy HCU was reduced by approx. 98% after only 30 minutes.Markus BongertJan WüstJustus StrauchDirk BuchwaldDe Gruyterarticleheater cooler unitdisinfectionozoneecmomycobacterium chimaeracomputational fluid dynamicsexperimental rig “o3desi”MedicineRENCurrent Directions in Biomedical Engineering, Vol 6, Iss 3, Pp 292-294 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	heater cooler unit disinfection ozone ecmo mycobacterium chimaera computational fluid dynamics experimental rig “o3desi” Medicine R
spellingShingle	heater cooler unit disinfection ozone ecmo mycobacterium chimaera computational fluid dynamics experimental rig “o3desi” Medicine R Markus Bongert Jan Wüst Justus Strauch Dirk Buchwald Proof of Concept for Ozone-Based Disinfection of Heater Cooler Units
description	Heater Cooler Units (HCUs) are frequently used not only during heart surgery but also in ECMO therapy to regulate the blood temperature of patients. It is known from cardiac surgery that the water circuits of HCUs can be bacterially contaminated and under adverse conditions can lead to a nosocomial infection of the patient. The addition of chemical disinfectants to the water of HCUs is problematic. In addition, it is an increasingly significant cost factor due to the required material and personnel input. The aim of this research project is both the development of an automated device for disinfecting water in HCUs and proof of its effectiveness. The device is based on ozone, a substance with known antimicrobial properties. To prevent ozone from coming into contact with the HCU components, the water is irradiated with UV light (254nm). Two bypasses and ozone sensors guarantee a complete elimination of residual ozone. The effectiveness of the device was tested by series of experiments with the surrogate germ, Pseudomonas aeruginosa. The device allows a wide range of ozone concentrations and exposure times to be selected. In previous test series, it has been shown both that a reduction of the bacterial count to drinking water quality can be achieved with a treatment time of only one hour, and that self-cleaning can be carried out effectively before clinical use, and in standby mode. Attention must be paid to the water quality in HCUs as a potential source of infection, regardless of where they are used. The "proof of concept" showed an excellent disinfection effect with simultaneous elimination of excess ozone to drinking water levels. The number of indicator bacteria in the water tank of the dummy HCU was reduced by approx. 98% after only 30 minutes.
format	article
author	Markus Bongert Jan Wüst Justus Strauch Dirk Buchwald
author_facet	Markus Bongert Jan Wüst Justus Strauch Dirk Buchwald
author_sort	Markus Bongert
title	Proof of Concept for Ozone-Based Disinfection of Heater Cooler Units
title_short	Proof of Concept for Ozone-Based Disinfection of Heater Cooler Units
title_full	Proof of Concept for Ozone-Based Disinfection of Heater Cooler Units
title_fullStr	Proof of Concept for Ozone-Based Disinfection of Heater Cooler Units
title_full_unstemmed	Proof of Concept for Ozone-Based Disinfection of Heater Cooler Units
title_sort	proof of concept for ozone-based disinfection of heater cooler units
publisher	De Gruyter
publishDate	2020
url	https://doaj.org/article/055aaa9dd2cb411ea3e332ea2814e218
work_keys_str_mv	AT markusbongert proofofconceptforozonebaseddisinfectionofheatercoolerunits AT janwust proofofconceptforozonebaseddisinfectionofheatercoolerunits AT justusstrauch proofofconceptforozonebaseddisinfectionofheatercoolerunits AT dirkbuchwald proofofconceptforozonebaseddisinfectionofheatercoolerunits
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Proof of Concept for Ozone-Based Disinfection of Heater Cooler Units

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