Pyrin-only protein 2 limits inflammation but improves protection against bacteria

Pyrin-only protein 2 limits inflammation but improves protection against bacteria

Pyrin-only proteins (POPs) are primate-specific negative regulators of inflammasome activation. Here the authors generate transgenic mice expressing POP2 under the control of the human promoter, and show that POP2 is important for balancing antibacterial inflammatory responsesin vivo.

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Autores principales: Sivakumar Periasamy, Kristen A. Porter, Maninjay K. Atianand, Hongnga T. Le, Sarah Earley, Ellen B. Duffy, Matthew C. Haller, Heather Chin, Jonathan A. Harton
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/0563f30dbd054df89affef0a6ff7f607
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spelling oai:doaj.org-article:0563f30dbd054df89affef0a6ff7f6072021-12-02T17:06:11ZPyrin-only protein 2 limits inflammation but improves protection against bacteria10.1038/ncomms155642041-1723https://doaj.org/article/0563f30dbd054df89affef0a6ff7f6072017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15564https://doaj.org/toc/2041-1723Pyrin-only proteins (POPs) are primate-specific negative regulators of inflammasome activation. Here the authors generate transgenic mice expressing POP2 under the control of the human promoter, and show that POP2 is important for balancing antibacterial inflammatory responsesin vivo.Sivakumar PeriasamyKristen A. PorterManinjay K. AtianandHongnga T. LeSarah EarleyEllen B. DuffyMatthew C. HallerHeather ChinJonathan A. HartonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Sivakumar Periasamy
Kristen A. Porter
Maninjay K. Atianand
Hongnga T. Le
Sarah Earley
Ellen B. Duffy
Matthew C. Haller
Heather Chin
Jonathan A. Harton
Pyrin-only protein 2 limits inflammation but improves protection against bacteria
description Pyrin-only proteins (POPs) are primate-specific negative regulators of inflammasome activation. Here the authors generate transgenic mice expressing POP2 under the control of the human promoter, and show that POP2 is important for balancing antibacterial inflammatory responsesin vivo.
format article
author Sivakumar Periasamy
Kristen A. Porter
Maninjay K. Atianand
Hongnga T. Le
Sarah Earley
Ellen B. Duffy
Matthew C. Haller
Heather Chin
Jonathan A. Harton
author_facet Sivakumar Periasamy
Kristen A. Porter
Maninjay K. Atianand
Hongnga T. Le
Sarah Earley
Ellen B. Duffy
Matthew C. Haller
Heather Chin
Jonathan A. Harton
author_sort Sivakumar Periasamy
title Pyrin-only protein 2 limits inflammation but improves protection against bacteria
title_short Pyrin-only protein 2 limits inflammation but improves protection against bacteria
title_full Pyrin-only protein 2 limits inflammation but improves protection against bacteria
title_fullStr Pyrin-only protein 2 limits inflammation but improves protection against bacteria
title_full_unstemmed Pyrin-only protein 2 limits inflammation but improves protection against bacteria
title_sort pyrin-only protein 2 limits inflammation but improves protection against bacteria
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/0563f30dbd054df89affef0a6ff7f607
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AT maninjaykatianand pyrinonlyprotein2limitsinflammationbutimprovesprotectionagainstbacteria
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