Comparison of Antiobesity Effects of Adipose-Derived Stromal/Stem Cells from Different Sources in a Natural Aging Model
Yu Zhu,1– 3,* Tao Wang,1– 3,* Shuangli He,1– 3 Shiming Pu,1– 3 Hongxia Zhao,1– 3 Zuping Zhou,1– 3 Qiong Wu1– 3 1School of Life Sciences, Guangxi Normal University, Guilin, Guangxi Zhuang Autonomous Region, People’s Republic of China; 2Guangxi Universities Key Laboratory of Stem Cell...
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| Formato: | article |
| Lenguaje: | EN |
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Dove Medical Press
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/05642ab92ac043149f54fcc9dde9bb08 |
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| Sumario: | Yu Zhu,1– 3,* Tao Wang,1– 3,* Shuangli He,1– 3 Shiming Pu,1– 3 Hongxia Zhao,1– 3 Zuping Zhou,1– 3 Qiong Wu1– 3 1School of Life Sciences, Guangxi Normal University, Guilin, Guangxi Zhuang Autonomous Region, People’s Republic of China; 2Guangxi Universities Key Laboratory of Stem Cell and Biopharmaceutical Technology, Guangxi Normal University, Guilin, Guangxi Zhuang Autonomous Region, People’s Republic of China; 3Research Center for Biomedical Sciences, Guangxi Normal University, Guilin, Guangxi Zhuang Autonomous Region, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qiong Wu Tel +86 18978327544Email wubinbin02@163.comPurpose: Our previous study found that white adipose stem cells (W-ASCs) derived from abdominal and femoral sulcus white adipose stem cells (ASCs) have antiaging and age-related obesity effects. Whether interscapular brown adipose stem cells (B-ASCs) have the same effect has not been reported. The study objective was to compare the effects of ASCs from different tissues on aging and aging-related obesity.Patients and Methods: C57BL/6J mice at 22 months of age were transplanted with either B-ASCs or W-ASCs from young mice at 2 months of age. Changes in body weight, biochemistry, cytokines, hormone secretion, cell senescence, lipid metabolism, and ASC function were assessed after transplanted 1 month.Results: W-ASCs were superior to B-ASCs as aging and age-related obesity indicators, based on change in body weight, organ weight, antioxidant and anti-inflammatory activity, lipid metabolism, and liver and kidney function.Conclusion: Difference in the tissue source was reflected by the heterogeneity of antiaging and age-related obesity effects of transplanted ASCs. Based on the study results, we recommend W-ASCs over B-ASCs in aging and age-related obesity applications.Keywords: adipose-derived stromal/stem cells, different tissue sources, obesity, aging |
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