Tumour-derived Interleukin 35 promotes pancreatic ductal adenocarcinoma cell extravasation and metastasis by inducing ICAM1 expression
Interleukin-35 (IL-35) is an immune suppressive cytokine produced by T-cells. Here, the authors show that IL-35 is overexpressed by human pancreatic cancer cells and show, in a mouse model, that IL-35 promotes metastasis in an autocrine/paracrine manner via induction of ICAM-1 expression.
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| Auteurs principaux: | , , , , , , , , , , , , , , |
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| Format: | article |
| Langue: | EN |
| Publié: |
Nature Portfolio
2017
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| Sujets: | |
| Accès en ligne: | https://doaj.org/article/05647a54a54d4a00b761a25ce2b1a8aa |
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| Résumé: | Interleukin-35 (IL-35) is an immune suppressive cytokine produced by T-cells. Here, the authors show that IL-35 is overexpressed by human pancreatic cancer cells and show, in a mouse model, that IL-35 promotes metastasis in an autocrine/paracrine manner via induction of ICAM-1 expression. |
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