Tumour-derived Interleukin 35 promotes pancreatic ductal adenocarcinoma cell extravasation and metastasis by inducing ICAM1 expression

Interleukin-35 (IL-35) is an immune suppressive cytokine produced by T-cells. Here, the authors show that IL-35 is overexpressed by human pancreatic cancer cells and show, in a mouse model, that IL-35 promotes metastasis in an autocrine/paracrine manner via induction of ICAM-1 expression.

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Autores principales:	Chongbiao Huang, Na Li, Zengxun Li, Antao Chang, Yanan Chen, Tiansuo Zhao, Yang Li, Xiuchao Wang, Wei Zhang, Zhimin Wang, Lin Luo, Jingjing Shi, Shengyu Yang, He Ren, Jihui Hao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/05647a54a54d4a00b761a25ce2b1a8aa
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spelling	oai:doaj.org-article:05647a54a54d4a00b761a25ce2b1a8aa2021-12-02T14:42:37ZTumour-derived Interleukin 35 promotes pancreatic ductal adenocarcinoma cell extravasation and metastasis by inducing ICAM1 expression10.1038/ncomms140352041-1723https://doaj.org/article/05647a54a54d4a00b761a25ce2b1a8aa2017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14035https://doaj.org/toc/2041-1723Interleukin-35 (IL-35) is an immune suppressive cytokine produced by T-cells. Here, the authors show that IL-35 is overexpressed by human pancreatic cancer cells and show, in a mouse model, that IL-35 promotes metastasis in an autocrine/paracrine manner via induction of ICAM-1 expression.Chongbiao HuangNa LiZengxun LiAntao ChangYanan ChenTiansuo ZhaoYang LiXiuchao WangWei ZhangZhimin WangLin LuoJingjing ShiShengyu YangHe RenJihui HaoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chongbiao Huang Na Li Zengxun Li Antao Chang Yanan Chen Tiansuo Zhao Yang Li Xiuchao Wang Wei Zhang Zhimin Wang Lin Luo Jingjing Shi Shengyu Yang He Ren Jihui Hao Tumour-derived Interleukin 35 promotes pancreatic ductal adenocarcinoma cell extravasation and metastasis by inducing ICAM1 expression
description	Interleukin-35 (IL-35) is an immune suppressive cytokine produced by T-cells. Here, the authors show that IL-35 is overexpressed by human pancreatic cancer cells and show, in a mouse model, that IL-35 promotes metastasis in an autocrine/paracrine manner via induction of ICAM-1 expression.
format	article
author	Chongbiao Huang Na Li Zengxun Li Antao Chang Yanan Chen Tiansuo Zhao Yang Li Xiuchao Wang Wei Zhang Zhimin Wang Lin Luo Jingjing Shi Shengyu Yang He Ren Jihui Hao
author_facet	Chongbiao Huang Na Li Zengxun Li Antao Chang Yanan Chen Tiansuo Zhao Yang Li Xiuchao Wang Wei Zhang Zhimin Wang Lin Luo Jingjing Shi Shengyu Yang He Ren Jihui Hao
author_sort	Chongbiao Huang
title	Tumour-derived Interleukin 35 promotes pancreatic ductal adenocarcinoma cell extravasation and metastasis by inducing ICAM1 expression
title_short	Tumour-derived Interleukin 35 promotes pancreatic ductal adenocarcinoma cell extravasation and metastasis by inducing ICAM1 expression
title_full	Tumour-derived Interleukin 35 promotes pancreatic ductal adenocarcinoma cell extravasation and metastasis by inducing ICAM1 expression
title_fullStr	Tumour-derived Interleukin 35 promotes pancreatic ductal adenocarcinoma cell extravasation and metastasis by inducing ICAM1 expression
title_full_unstemmed	Tumour-derived Interleukin 35 promotes pancreatic ductal adenocarcinoma cell extravasation and metastasis by inducing ICAM1 expression
title_sort	tumour-derived interleukin 35 promotes pancreatic ductal adenocarcinoma cell extravasation and metastasis by inducing icam1 expression
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/05647a54a54d4a00b761a25ce2b1a8aa
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Tumour-derived Interleukin 35 promotes pancreatic ductal adenocarcinoma cell extravasation and metastasis by inducing ICAM1 expression

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