Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection

Here, via screening of a polypeptide library from bronchoalveolar lavage, the authors identify and characterize α1-antitrypsin (α1AT) as SARS-CoV-2 inhibitor and show that α1AT binds and inactivates the serine protease TMPRSS2, which enzymatically primes the SARS-CoV-2 spike protein for membrane fus...

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Autores principales:	Lukas Wettstein, Tatjana Weil, Carina Conzelmann, Janis A. Müller, Rüdiger Groß, Maximilian Hirschenberger, Alina Seidel, Susanne Klute, Fabian Zech, Caterina Prelli Bozzo, Nico Preising, Giorgio Fois, Robin Lochbaum, Philip Maximilian Knaff, Volker Mailänder, Ludger Ständker, Dietmar Rudolf Thal, Christian Schumann, Steffen Stenger, Alexander Kleger, Günter Lochnit, Benjamin Mayer, Yasser B. Ruiz-Blanco, Markus Hoffmann, Konstantin M. J. Sparrer, Stefan Pöhlmann, Elsa Sanchez-Garcia, Frank Kirchhoff, Manfred Frick, Jan Münch
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/056726122e3545e6b5177624a1dc537a
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spelling	oai:doaj.org-article:056726122e3545e6b5177624a1dc537a2021-12-02T17:04:54ZAlpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection10.1038/s41467-021-21972-02041-1723https://doaj.org/article/056726122e3545e6b5177624a1dc537a2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21972-0https://doaj.org/toc/2041-1723Here, via screening of a polypeptide library from bronchoalveolar lavage, the authors identify and characterize α1-antitrypsin (α1AT) as SARS-CoV-2 inhibitor and show that α1AT binds and inactivates the serine protease TMPRSS2, which enzymatically primes the SARS-CoV-2 spike protein for membrane fusion.Lukas WettsteinTatjana WeilCarina ConzelmannJanis A. MüllerRüdiger GroßMaximilian HirschenbergerAlina SeidelSusanne KluteFabian ZechCaterina Prelli BozzoNico PreisingGiorgio FoisRobin LochbaumPhilip Maximilian KnaffVolker MailänderLudger StändkerDietmar Rudolf ThalChristian SchumannSteffen StengerAlexander KlegerGünter LochnitBenjamin MayerYasser B. Ruiz-BlancoMarkus HoffmannKonstantin M. J. SparrerStefan PöhlmannElsa Sanchez-GarciaFrank KirchhoffManfred FrickJan MünchNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lukas Wettstein Tatjana Weil Carina Conzelmann Janis A. Müller Rüdiger Groß Maximilian Hirschenberger Alina Seidel Susanne Klute Fabian Zech Caterina Prelli Bozzo Nico Preising Giorgio Fois Robin Lochbaum Philip Maximilian Knaff Volker Mailänder Ludger Ständker Dietmar Rudolf Thal Christian Schumann Steffen Stenger Alexander Kleger Günter Lochnit Benjamin Mayer Yasser B. Ruiz-Blanco Markus Hoffmann Konstantin M. J. Sparrer Stefan Pöhlmann Elsa Sanchez-Garcia Frank Kirchhoff Manfred Frick Jan Münch Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection
description	Here, via screening of a polypeptide library from bronchoalveolar lavage, the authors identify and characterize α1-antitrypsin (α1AT) as SARS-CoV-2 inhibitor and show that α1AT binds and inactivates the serine protease TMPRSS2, which enzymatically primes the SARS-CoV-2 spike protein for membrane fusion.
format	article
author	Lukas Wettstein Tatjana Weil Carina Conzelmann Janis A. Müller Rüdiger Groß Maximilian Hirschenberger Alina Seidel Susanne Klute Fabian Zech Caterina Prelli Bozzo Nico Preising Giorgio Fois Robin Lochbaum Philip Maximilian Knaff Volker Mailänder Ludger Ständker Dietmar Rudolf Thal Christian Schumann Steffen Stenger Alexander Kleger Günter Lochnit Benjamin Mayer Yasser B. Ruiz-Blanco Markus Hoffmann Konstantin M. J. Sparrer Stefan Pöhlmann Elsa Sanchez-Garcia Frank Kirchhoff Manfred Frick Jan Münch
author_facet	Lukas Wettstein Tatjana Weil Carina Conzelmann Janis A. Müller Rüdiger Groß Maximilian Hirschenberger Alina Seidel Susanne Klute Fabian Zech Caterina Prelli Bozzo Nico Preising Giorgio Fois Robin Lochbaum Philip Maximilian Knaff Volker Mailänder Ludger Ständker Dietmar Rudolf Thal Christian Schumann Steffen Stenger Alexander Kleger Günter Lochnit Benjamin Mayer Yasser B. Ruiz-Blanco Markus Hoffmann Konstantin M. J. Sparrer Stefan Pöhlmann Elsa Sanchez-Garcia Frank Kirchhoff Manfred Frick Jan Münch
author_sort	Lukas Wettstein
title	Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection
title_short	Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection
title_full	Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection
title_fullStr	Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection
title_full_unstemmed	Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection
title_sort	alpha-1 antitrypsin inhibits tmprss2 protease activity and sars-cov-2 infection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/056726122e3545e6b5177624a1dc537a
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Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection

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