The co-treatment of rosuvastatin with dapagliflozin synergistically inhibited apoptosis via activating the PI3K/AKt/mTOR signaling pathway in myocardial ischemia/reperfusion injury rats

The co-treatment of rosuvastatin with dapagliflozin synergistically inhibited apoptosis via activating the PI3K/AKt/mTOR signaling pathway in myocardial ischemia/reperfusion injury rats

The purpose of the present study was to evaluate the role of co-treatment of rosuvastatin (RSV) and dapagliflozin (DGZ) preconditioning in myocardium ischemia/reperfusion (I/R) injury and to further investigate the underlying mechanism.

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Autores principales: Gong Lei, Wang Xuyang, Pan Jinyu, Zhang Mingjun, Liu Dian, Liu Ming, Li Li, An Fengshuang
Formato: article
Lenguaje:EN
Publicado: De Gruyter 2020
Materias:
rosuvastatin
dapagliflozin
apoptosis
pi3k/akt/mtor
ischemia/reperfusion
Medicine
R
Acceso en línea:https://doaj.org/article/0569fe67ae6d45359ff50cf2dbfafd14
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spelling oai:doaj.org-article:0569fe67ae6d45359ff50cf2dbfafd142021-12-05T14:10:53ZThe co-treatment of rosuvastatin with dapagliflozin synergistically inhibited apoptosis via activating the PI3K/AKt/mTOR signaling pathway in myocardial ischemia/reperfusion injury rats2391-546310.1515/med-2021-0005https://doaj.org/article/0569fe67ae6d45359ff50cf2dbfafd142020-12-01T00:00:00Zhttps://doi.org/10.1515/med-2021-0005https://doaj.org/toc/2391-5463The purpose of the present study was to evaluate the role of co-treatment of rosuvastatin (RSV) and dapagliflozin (DGZ) preconditioning in myocardium ischemia/reperfusion (I/R) injury and to further investigate the underlying mechanism.Gong LeiWang XuyangPan JinyuZhang MingjunLiu DianLiu MingLi LiAn FengshuangDe Gruyterarticlerosuvastatindapagliflozinapoptosispi3k/akt/mtorischemia/reperfusionMedicineRENOpen Medicine, Vol 16, Iss 1, Pp 047-057 (2020)
institution DOAJ
collection DOAJ
language EN
topic rosuvastatin
dapagliflozin
apoptosis
pi3k/akt/mtor
ischemia/reperfusion
Medicine
R
spellingShingle rosuvastatin
dapagliflozin
apoptosis
pi3k/akt/mtor
ischemia/reperfusion
Medicine
R
Gong Lei
Wang Xuyang
Pan Jinyu
Zhang Mingjun
Liu Dian
Liu Ming
Li Li
An Fengshuang
The co-treatment of rosuvastatin with dapagliflozin synergistically inhibited apoptosis via activating the PI3K/AKt/mTOR signaling pathway in myocardial ischemia/reperfusion injury rats
description The purpose of the present study was to evaluate the role of co-treatment of rosuvastatin (RSV) and dapagliflozin (DGZ) preconditioning in myocardium ischemia/reperfusion (I/R) injury and to further investigate the underlying mechanism.
format article
author Gong Lei
Wang Xuyang
Pan Jinyu
Zhang Mingjun
Liu Dian
Liu Ming
Li Li
An Fengshuang
author_facet Gong Lei
Wang Xuyang
Pan Jinyu
Zhang Mingjun
Liu Dian
Liu Ming
Li Li
An Fengshuang
author_sort Gong Lei
title The co-treatment of rosuvastatin with dapagliflozin synergistically inhibited apoptosis via activating the PI3K/AKt/mTOR signaling pathway in myocardial ischemia/reperfusion injury rats
title_short The co-treatment of rosuvastatin with dapagliflozin synergistically inhibited apoptosis via activating the PI3K/AKt/mTOR signaling pathway in myocardial ischemia/reperfusion injury rats
title_full The co-treatment of rosuvastatin with dapagliflozin synergistically inhibited apoptosis via activating the PI3K/AKt/mTOR signaling pathway in myocardial ischemia/reperfusion injury rats
title_fullStr The co-treatment of rosuvastatin with dapagliflozin synergistically inhibited apoptosis via activating the PI3K/AKt/mTOR signaling pathway in myocardial ischemia/reperfusion injury rats
title_full_unstemmed The co-treatment of rosuvastatin with dapagliflozin synergistically inhibited apoptosis via activating the PI3K/AKt/mTOR signaling pathway in myocardial ischemia/reperfusion injury rats
title_sort co-treatment of rosuvastatin with dapagliflozin synergistically inhibited apoptosis via activating the pi3k/akt/mtor signaling pathway in myocardial ischemia/reperfusion injury rats
publisher De Gruyter
publishDate 2020
url https://doaj.org/article/0569fe67ae6d45359ff50cf2dbfafd14
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