The co-treatment of rosuvastatin with dapagliflozin synergistically inhibited apoptosis via activating the PI3K/AKt/mTOR signaling pathway in myocardial ischemia/reperfusion injury rats

The co-treatment of rosuvastatin with dapagliflozin synergistically inhibited apoptosis via activating the PI3K/AKt/mTOR signaling pathway in myocardial ischemia/reperfusion injury rats

The purpose of the present study was to evaluate the role of co-treatment of rosuvastatin (RSV) and dapagliflozin (DGZ) preconditioning in myocardium ischemia/reperfusion (I/R) injury and to further investigate the underlying mechanism.

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Autores principales: Gong Lei, Wang Xuyang, Pan Jinyu, Zhang Mingjun, Liu Dian, Liu Ming, Li Li, An Fengshuang
Formato: article
Lenguaje:EN
Publicado: De Gruyter 2020
Materias:
rosuvastatin
dapagliflozin
apoptosis
pi3k/akt/mtor
ischemia/reperfusion
Medicine
R
Acceso en línea:https://doaj.org/article/0569fe67ae6d45359ff50cf2dbfafd14
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