Efficacy and Safety of Mecobalamin Combined with Prokinetic Agents in the Treatment of Diabetic Gastroparesis: A Meta-Analysis

Background: The aim of the present study was to systematically review the efficacy and safety of mecobalamin combined with prokinetic agents in diabetic gastroparesis (DGP). Methods: A variety of databases were searched from inception to Nov 2, 2018. RCTs of mecobalamin combined with prokinetic...

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Autores principales:	Jia Yao, Bo Peng, Xia yu Gong, Xiaoyan Shi, Simin Fan, Qiu Chen
Formato:	article
Lenguaje:	EN
Publicado:	Tehran University of Medical Sciences 2021
Materias:	Mecobalamin Prokinetic agents Diabetic gastroparesis Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/056a488b058547f59a87dc77e3260c07
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spelling	oai:doaj.org-article:056a488b058547f59a87dc77e3260c072021-12-02T18:23:25ZEfficacy and Safety of Mecobalamin Combined with Prokinetic Agents in the Treatment of Diabetic Gastroparesis: A Meta-Analysis2251-60852251-6093https://doaj.org/article/056a488b058547f59a87dc77e3260c072021-10-01T00:00:00Zhttps://ijph.tums.ac.ir/index.php/ijph/article/view/18699https://doaj.org/toc/2251-6085https://doaj.org/toc/2251-6093 Background: The aim of the present study was to systematically review the efficacy and safety of mecobalamin combined with prokinetic agents in diabetic gastroparesis (DGP). Methods: A variety of databases were searched from inception to Nov 2, 2018. RCTs of mecobalamin combined with prokinetic agents group (experimental group) versus prokinetic agents only group (control group) in DGP were included. RevMan 5.3 and Stata 12.0 were used to perform the meta-analysis. Finally, 24 RCTs with 1,878 patients were included. Results: The total efficacy rate was significantly higher in the experimental group (mecobalamin combined with prokinetic drugs) compared with the control group (prokinetic drugs alone) (P<0.001), and the improvement was observed regardless of the administration route. Furthermore, the treatment group exhibited a significantly improved gastric emption rate (P<0.001), motilin (P<0.001) and recurrence rate (P<0.001), and there was no statistical difference in the incidence of adverse reactions between two groups (P=0.49). Conclusion: Mecobalamin combined with prokinetic agents can significantly improve total efficacy rate and gastric emptying rate, decrease serum motilin and the recurrence rate without increasing adverse reactions in DGP. Thus, mecobalamin may can be used as a new therapeutic option for DGP. Jia YaoBo PengXia yu GongXiaoyan ShiSimin FanQiu ChenTehran University of Medical SciencesarticleMecobalaminProkinetic agentsDiabetic gastroparesisPublic aspects of medicineRA1-1270ENIranian Journal of Public Health, Vol 50, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Mecobalamin Prokinetic agents Diabetic gastroparesis Public aspects of medicine RA1-1270
spellingShingle	Mecobalamin Prokinetic agents Diabetic gastroparesis Public aspects of medicine RA1-1270 Jia Yao Bo Peng Xia yu Gong Xiaoyan Shi Simin Fan Qiu Chen Efficacy and Safety of Mecobalamin Combined with Prokinetic Agents in the Treatment of Diabetic Gastroparesis: A Meta-Analysis
description	Background: The aim of the present study was to systematically review the efficacy and safety of mecobalamin combined with prokinetic agents in diabetic gastroparesis (DGP). Methods: A variety of databases were searched from inception to Nov 2, 2018. RCTs of mecobalamin combined with prokinetic agents group (experimental group) versus prokinetic agents only group (control group) in DGP were included. RevMan 5.3 and Stata 12.0 were used to perform the meta-analysis. Finally, 24 RCTs with 1,878 patients were included. Results: The total efficacy rate was significantly higher in the experimental group (mecobalamin combined with prokinetic drugs) compared with the control group (prokinetic drugs alone) (P<0.001), and the improvement was observed regardless of the administration route. Furthermore, the treatment group exhibited a significantly improved gastric emption rate (P<0.001), motilin (P<0.001) and recurrence rate (P<0.001), and there was no statistical difference in the incidence of adverse reactions between two groups (P=0.49). Conclusion: Mecobalamin combined with prokinetic agents can significantly improve total efficacy rate and gastric emptying rate, decrease serum motilin and the recurrence rate without increasing adverse reactions in DGP. Thus, mecobalamin may can be used as a new therapeutic option for DGP.
format	article
author	Jia Yao Bo Peng Xia yu Gong Xiaoyan Shi Simin Fan Qiu Chen
author_facet	Jia Yao Bo Peng Xia yu Gong Xiaoyan Shi Simin Fan Qiu Chen
author_sort	Jia Yao
title	Efficacy and Safety of Mecobalamin Combined with Prokinetic Agents in the Treatment of Diabetic Gastroparesis: A Meta-Analysis
title_short	Efficacy and Safety of Mecobalamin Combined with Prokinetic Agents in the Treatment of Diabetic Gastroparesis: A Meta-Analysis
title_full	Efficacy and Safety of Mecobalamin Combined with Prokinetic Agents in the Treatment of Diabetic Gastroparesis: A Meta-Analysis
title_fullStr	Efficacy and Safety of Mecobalamin Combined with Prokinetic Agents in the Treatment of Diabetic Gastroparesis: A Meta-Analysis
title_full_unstemmed	Efficacy and Safety of Mecobalamin Combined with Prokinetic Agents in the Treatment of Diabetic Gastroparesis: A Meta-Analysis
title_sort	efficacy and safety of mecobalamin combined with prokinetic agents in the treatment of diabetic gastroparesis: a meta-analysis
publisher	Tehran University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/056a488b058547f59a87dc77e3260c07
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Efficacy and Safety of Mecobalamin Combined with Prokinetic Agents in the Treatment of Diabetic Gastroparesis: A Meta-Analysis

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