Nasopharyngeal Pneumococcal Carriage in Nigeria: a two-site, population-based survey

Abstract Changes in nasopharyngeal (NP) carriage of vaccine-type (VT) Streptococcus pneumoniae can be used to assess the effectiveness of a pneumococcal conjugate vaccine (PCV10). We conducted a baseline carriage survey in rural (Kumbotso, Kano) and urban (Pakoto, Ogun) Nigeria. In this cross-sectio...

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Autores principales:	Ifedayo M. O. Adetifa, Aishatu L. Adamu, Angela Karani, Michael Waithaka, Kofo A. Odeyemi, Christy A. N. Okoromah, Mohammed M. Bello, Isa S. Abubakar, Victor Inem, J. Anthony. G. Scott
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/056c3d19e1884cb39886c2ace9ea5564
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spelling	oai:doaj.org-article:056c3d19e1884cb39886c2ace9ea55642021-12-02T11:40:15ZNasopharyngeal Pneumococcal Carriage in Nigeria: a two-site, population-based survey10.1038/s41598-018-21837-52045-2322https://doaj.org/article/056c3d19e1884cb39886c2ace9ea55642018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-21837-5https://doaj.org/toc/2045-2322Abstract Changes in nasopharyngeal (NP) carriage of vaccine-type (VT) Streptococcus pneumoniae can be used to assess the effectiveness of a pneumococcal conjugate vaccine (PCV10). We conducted a baseline carriage survey in rural (Kumbotso, Kano) and urban (Pakoto, Ogun) Nigeria. In this cross-sectional study, we obtained data on demography, clinical history, risk factors, and took NP swabs for pneumococcal culture. We calculated crude and age-standardised carriage prevalence and used log-binomial regression to assess risk factors for carriage. Among children aged <5 years, 92% (95% CI: 88–95%) and 78% (73–82%), respectively, carried any pneumococcus and 48% and 50%, respectively, carried PCV10 serotypes. In Kumbotso, carriage prevalence was >40% across all ages. The age-standardized prevalence of pneumococcal carriage was 66% in Kumbotso and 40% in Pakoto. The most commonly identified serotypes were 19 F, 6 A and 23 F. Risk factors for carriage were young age, recent rhinorrhoea, cohabitation with ≥2 children aged <5 years, and sharing a bed with ≥2 persons. Pneumococcal carriage prevalence is high in this Nigerian population. Persisting prevalence of VT-carriage in older children and adults suggests that PCV10 introduction in children will not eliminate transmission of vaccine serotypes rapidly. High vaccine coverage will therefore be required to ensure full protection of children.Ifedayo M. O. AdetifaAishatu L. AdamuAngela KaraniMichael WaithakaKofo A. OdeyemiChristy A. N. OkoromahMohammed M. BelloIsa S. AbubakarVictor InemJ. Anthony. G. ScottNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ifedayo M. O. Adetifa Aishatu L. Adamu Angela Karani Michael Waithaka Kofo A. Odeyemi Christy A. N. Okoromah Mohammed M. Bello Isa S. Abubakar Victor Inem J. Anthony. G. Scott Nasopharyngeal Pneumococcal Carriage in Nigeria: a two-site, population-based survey
description	Abstract Changes in nasopharyngeal (NP) carriage of vaccine-type (VT) Streptococcus pneumoniae can be used to assess the effectiveness of a pneumococcal conjugate vaccine (PCV10). We conducted a baseline carriage survey in rural (Kumbotso, Kano) and urban (Pakoto, Ogun) Nigeria. In this cross-sectional study, we obtained data on demography, clinical history, risk factors, and took NP swabs for pneumococcal culture. We calculated crude and age-standardised carriage prevalence and used log-binomial regression to assess risk factors for carriage. Among children aged <5 years, 92% (95% CI: 88–95%) and 78% (73–82%), respectively, carried any pneumococcus and 48% and 50%, respectively, carried PCV10 serotypes. In Kumbotso, carriage prevalence was >40% across all ages. The age-standardized prevalence of pneumococcal carriage was 66% in Kumbotso and 40% in Pakoto. The most commonly identified serotypes were 19 F, 6 A and 23 F. Risk factors for carriage were young age, recent rhinorrhoea, cohabitation with ≥2 children aged <5 years, and sharing a bed with ≥2 persons. Pneumococcal carriage prevalence is high in this Nigerian population. Persisting prevalence of VT-carriage in older children and adults suggests that PCV10 introduction in children will not eliminate transmission of vaccine serotypes rapidly. High vaccine coverage will therefore be required to ensure full protection of children.
format	article
author	Ifedayo M. O. Adetifa Aishatu L. Adamu Angela Karani Michael Waithaka Kofo A. Odeyemi Christy A. N. Okoromah Mohammed M. Bello Isa S. Abubakar Victor Inem J. Anthony. G. Scott
author_facet	Ifedayo M. O. Adetifa Aishatu L. Adamu Angela Karani Michael Waithaka Kofo A. Odeyemi Christy A. N. Okoromah Mohammed M. Bello Isa S. Abubakar Victor Inem J. Anthony. G. Scott
author_sort	Ifedayo M. O. Adetifa
title	Nasopharyngeal Pneumococcal Carriage in Nigeria: a two-site, population-based survey
title_short	Nasopharyngeal Pneumococcal Carriage in Nigeria: a two-site, population-based survey
title_full	Nasopharyngeal Pneumococcal Carriage in Nigeria: a two-site, population-based survey
title_fullStr	Nasopharyngeal Pneumococcal Carriage in Nigeria: a two-site, population-based survey
title_full_unstemmed	Nasopharyngeal Pneumococcal Carriage in Nigeria: a two-site, population-based survey
title_sort	nasopharyngeal pneumococcal carriage in nigeria: a two-site, population-based survey
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/056c3d19e1884cb39886c2ace9ea5564
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Nasopharyngeal Pneumococcal Carriage in Nigeria: a two-site, population-based survey

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