Incompatibility of the circadian protein BMAL1 and HNF4α in hepatocellular carcinoma

Incompatibility of the circadian protein BMAL1 and HNF4α in hepatocellular carcinoma

Hepatocyte nuclear factor 4 alpha (HNF4α) is regulated by different promoters to generate two isoforms, one of which functions as a tumor suppressor. Here, the authors reveal that induction of the alternative isoform in hepatocellular carcinoma inhibits the circadian clock by repressing BMAL1, and t...

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Autores principales: Baharan Fekry, Aleix Ribas-Latre, Corrine Baumgartner, Jonathan R. Deans, Christopher Kwok, Pooja Patel, Loning Fu, Rebecca Berdeaux, Kai Sun, Mikhail G. Kolonin, Sidney H. Wang, Seung-Hee Yoo, Frances M. Sladek, Kristin Eckel-Mahan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/056eef75c52b4174ad77b500303fd84c
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Sumario:Hepatocyte nuclear factor 4 alpha (HNF4α) is regulated by different promoters to generate two isoforms, one of which functions as a tumor suppressor. Here, the authors reveal that induction of the alternative isoform in hepatocellular carcinoma inhibits the circadian clock by repressing BMAL1, and the reintroduction of BMAL1 prevents HCC tumor growth.

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