Incompatibility of the circadian protein BMAL1 and HNF4α in hepatocellular carcinoma

Hepatocyte nuclear factor 4 alpha (HNF4α) is regulated by different promoters to generate two isoforms, one of which functions as a tumor suppressor. Here, the authors reveal that induction of the alternative isoform in hepatocellular carcinoma inhibits the circadian clock by repressing BMAL1, and t...

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Autores principales:	Baharan Fekry, Aleix Ribas-Latre, Corrine Baumgartner, Jonathan R. Deans, Christopher Kwok, Pooja Patel, Loning Fu, Rebecca Berdeaux, Kai Sun, Mikhail G. Kolonin, Sidney H. Wang, Seung-Hee Yoo, Frances M. Sladek, Kristin Eckel-Mahan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/056eef75c52b4174ad77b500303fd84c
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spelling	oai:doaj.org-article:056eef75c52b4174ad77b500303fd84c2021-12-02T17:33:16ZIncompatibility of the circadian protein BMAL1 and HNF4α in hepatocellular carcinoma10.1038/s41467-018-06648-62041-1723https://doaj.org/article/056eef75c52b4174ad77b500303fd84c2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06648-6https://doaj.org/toc/2041-1723Hepatocyte nuclear factor 4 alpha (HNF4α) is regulated by different promoters to generate two isoforms, one of which functions as a tumor suppressor. Here, the authors reveal that induction of the alternative isoform in hepatocellular carcinoma inhibits the circadian clock by repressing BMAL1, and the reintroduction of BMAL1 prevents HCC tumor growth.Baharan FekryAleix Ribas-LatreCorrine BaumgartnerJonathan R. DeansChristopher KwokPooja PatelLoning FuRebecca BerdeauxKai SunMikhail G. KoloninSidney H. WangSeung-Hee YooFrances M. SladekKristin Eckel-MahanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Baharan Fekry Aleix Ribas-Latre Corrine Baumgartner Jonathan R. Deans Christopher Kwok Pooja Patel Loning Fu Rebecca Berdeaux Kai Sun Mikhail G. Kolonin Sidney H. Wang Seung-Hee Yoo Frances M. Sladek Kristin Eckel-Mahan Incompatibility of the circadian protein BMAL1 and HNF4α in hepatocellular carcinoma
description	Hepatocyte nuclear factor 4 alpha (HNF4α) is regulated by different promoters to generate two isoforms, one of which functions as a tumor suppressor. Here, the authors reveal that induction of the alternative isoform in hepatocellular carcinoma inhibits the circadian clock by repressing BMAL1, and the reintroduction of BMAL1 prevents HCC tumor growth.
format	article
author	Baharan Fekry Aleix Ribas-Latre Corrine Baumgartner Jonathan R. Deans Christopher Kwok Pooja Patel Loning Fu Rebecca Berdeaux Kai Sun Mikhail G. Kolonin Sidney H. Wang Seung-Hee Yoo Frances M. Sladek Kristin Eckel-Mahan
author_facet	Baharan Fekry Aleix Ribas-Latre Corrine Baumgartner Jonathan R. Deans Christopher Kwok Pooja Patel Loning Fu Rebecca Berdeaux Kai Sun Mikhail G. Kolonin Sidney H. Wang Seung-Hee Yoo Frances M. Sladek Kristin Eckel-Mahan
author_sort	Baharan Fekry
title	Incompatibility of the circadian protein BMAL1 and HNF4α in hepatocellular carcinoma
title_short	Incompatibility of the circadian protein BMAL1 and HNF4α in hepatocellular carcinoma
title_full	Incompatibility of the circadian protein BMAL1 and HNF4α in hepatocellular carcinoma
title_fullStr	Incompatibility of the circadian protein BMAL1 and HNF4α in hepatocellular carcinoma
title_full_unstemmed	Incompatibility of the circadian protein BMAL1 and HNF4α in hepatocellular carcinoma
title_sort	incompatibility of the circadian protein bmal1 and hnf4α in hepatocellular carcinoma
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/056eef75c52b4174ad77b500303fd84c
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Incompatibility of the circadian protein BMAL1 and HNF4α in hepatocellular carcinoma

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