Links between fecal microbiota and the response to vaccination against influenza A virus in pigs

Abstract This study describes the associations between fecal microbiota and vaccine response variability in pigs, using 98 piglets vaccinated against the influenza A virus at 28 days of age (D28) with a booster at D49. Immune response to the vaccine is measured at D49, D56, D63, and D146 by serum le...

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Autores principales:	Marion Borey, Fany Blanc, Gaëtan Lemonnier, Jean-Jacques Leplat, Deborah Jardet, Marie-Noëlle Rossignol, Laure Ravon, Yvon Billon, Maria Bernard, Jordi Estellé, Claire Rogel-Gaillard
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/0571c91cbf704e3391623ea8594f60ee
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spelling	oai:doaj.org-article:0571c91cbf704e3391623ea8594f60ee2021-12-02T17:55:01ZLinks between fecal microbiota and the response to vaccination against influenza A virus in pigs10.1038/s41541-021-00351-22059-0105https://doaj.org/article/0571c91cbf704e3391623ea8594f60ee2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41541-021-00351-2https://doaj.org/toc/2059-0105Abstract This study describes the associations between fecal microbiota and vaccine response variability in pigs, using 98 piglets vaccinated against the influenza A virus at 28 days of age (D28) with a booster at D49. Immune response to the vaccine is measured at D49, D56, D63, and D146 by serum levels of IAV-specific IgG and assays of hemagglutination inhibition (HAI). Analysis of the pre-vaccination microbiota characterized by 16S rRNA gene sequencing of fecal DNA reveals a higher vaccine response in piglets with a richer microbiota, and shows that 23 operational taxonomic units (OTUs) are differentially abundant between high and low IAV-specific IgG producers at D63. A stronger immune response is linked with OTUs assigned to the genus Prevotella and family Muribaculaceae, and a weaker response is linked with OTUs assigned to the genera Helicobacter and Escherichia-Shigella. A set of 81 OTUs accurately predicts IAV-specific IgG and HAI titer levels at all time points, highlighting early and late associations between pre-vaccination fecal microbiota composition and immune response to the vaccine.Marion BoreyFany BlancGaëtan LemonnierJean-Jacques LeplatDeborah JardetMarie-Noëlle RossignolLaure RavonYvon BillonMaria BernardJordi EstelléClaire Rogel-GaillardNature PortfolioarticleImmunologic diseases. AllergyRC581-607Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Vaccines, Vol 6, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Marion Borey Fany Blanc Gaëtan Lemonnier Jean-Jacques Leplat Deborah Jardet Marie-Noëlle Rossignol Laure Ravon Yvon Billon Maria Bernard Jordi Estellé Claire Rogel-Gaillard Links between fecal microbiota and the response to vaccination against influenza A virus in pigs
description	Abstract This study describes the associations between fecal microbiota and vaccine response variability in pigs, using 98 piglets vaccinated against the influenza A virus at 28 days of age (D28) with a booster at D49. Immune response to the vaccine is measured at D49, D56, D63, and D146 by serum levels of IAV-specific IgG and assays of hemagglutination inhibition (HAI). Analysis of the pre-vaccination microbiota characterized by 16S rRNA gene sequencing of fecal DNA reveals a higher vaccine response in piglets with a richer microbiota, and shows that 23 operational taxonomic units (OTUs) are differentially abundant between high and low IAV-specific IgG producers at D63. A stronger immune response is linked with OTUs assigned to the genus Prevotella and family Muribaculaceae, and a weaker response is linked with OTUs assigned to the genera Helicobacter and Escherichia-Shigella. A set of 81 OTUs accurately predicts IAV-specific IgG and HAI titer levels at all time points, highlighting early and late associations between pre-vaccination fecal microbiota composition and immune response to the vaccine.
format	article
author	Marion Borey Fany Blanc Gaëtan Lemonnier Jean-Jacques Leplat Deborah Jardet Marie-Noëlle Rossignol Laure Ravon Yvon Billon Maria Bernard Jordi Estellé Claire Rogel-Gaillard
author_facet	Marion Borey Fany Blanc Gaëtan Lemonnier Jean-Jacques Leplat Deborah Jardet Marie-Noëlle Rossignol Laure Ravon Yvon Billon Maria Bernard Jordi Estellé Claire Rogel-Gaillard
author_sort	Marion Borey
title	Links between fecal microbiota and the response to vaccination against influenza A virus in pigs
title_short	Links between fecal microbiota and the response to vaccination against influenza A virus in pigs
title_full	Links between fecal microbiota and the response to vaccination against influenza A virus in pigs
title_fullStr	Links between fecal microbiota and the response to vaccination against influenza A virus in pigs
title_full_unstemmed	Links between fecal microbiota and the response to vaccination against influenza A virus in pigs
title_sort	links between fecal microbiota and the response to vaccination against influenza a virus in pigs
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0571c91cbf704e3391623ea8594f60ee
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Links between fecal microbiota and the response to vaccination against influenza A virus in pigs

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