A miR-327–FGF10–FGFR2-mediated autocrine signaling mechanism controls white fat browning

White adipocytes can be stimulated to express thermogenic genes in a process known as beiging. Here, the authors show that miR-327 is downregulated during beiging, which releases FGF10 from inhibition and supports beige adipocyte formation via signaling through FGFR2.

Saved in:

Bibliographic Details
Main Authors:	Carina Fischer, Takahiro Seki, Sharon Lim, Masaki Nakamura, Patrik Andersson, Yunlong Yang, Jennifer Honek, Yangang Wang, Yanyan Gao, Fang Chen, Nilesh J. Samani, Jun Zhang, Masato Miyake, Seiichi Oyadomari, Akihiro Yasue, Xuri Li, Yun Zhang, Yizhi Liu, Yihai Cao
Format:	article
Language:	EN
Published:	Nature Portfolio 2017
Subjects:	Science Q
Online Access:	https://doaj.org/article/05747f31616e4250bcc20f53bf04d105
Tags:	Add Tag No Tags, Be the first to tag this record!

id	oai:doaj.org-article:05747f31616e4250bcc20f53bf04d105
record_format	dspace
spelling	oai:doaj.org-article:05747f31616e4250bcc20f53bf04d1052021-12-02T15:39:03ZA miR-327–FGF10–FGFR2-mediated autocrine signaling mechanism controls white fat browning10.1038/s41467-017-02158-z2041-1723https://doaj.org/article/05747f31616e4250bcc20f53bf04d1052017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02158-zhttps://doaj.org/toc/2041-1723White adipocytes can be stimulated to express thermogenic genes in a process known as beiging. Here, the authors show that miR-327 is downregulated during beiging, which releases FGF10 from inhibition and supports beige adipocyte formation via signaling through FGFR2.Carina FischerTakahiro SekiSharon LimMasaki NakamuraPatrik AnderssonYunlong YangJennifer HonekYangang WangYanyan GaoFang ChenNilesh J. SamaniJun ZhangMasato MiyakeSeiichi OyadomariAkihiro YasueXuri LiYun ZhangYizhi LiuYihai CaoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Carina Fischer Takahiro Seki Sharon Lim Masaki Nakamura Patrik Andersson Yunlong Yang Jennifer Honek Yangang Wang Yanyan Gao Fang Chen Nilesh J. Samani Jun Zhang Masato Miyake Seiichi Oyadomari Akihiro Yasue Xuri Li Yun Zhang Yizhi Liu Yihai Cao A miR-327–FGF10–FGFR2-mediated autocrine signaling mechanism controls white fat browning
description	White adipocytes can be stimulated to express thermogenic genes in a process known as beiging. Here, the authors show that miR-327 is downregulated during beiging, which releases FGF10 from inhibition and supports beige adipocyte formation via signaling through FGFR2.
format	article
author	Carina Fischer Takahiro Seki Sharon Lim Masaki Nakamura Patrik Andersson Yunlong Yang Jennifer Honek Yangang Wang Yanyan Gao Fang Chen Nilesh J. Samani Jun Zhang Masato Miyake Seiichi Oyadomari Akihiro Yasue Xuri Li Yun Zhang Yizhi Liu Yihai Cao
author_facet	Carina Fischer Takahiro Seki Sharon Lim Masaki Nakamura Patrik Andersson Yunlong Yang Jennifer Honek Yangang Wang Yanyan Gao Fang Chen Nilesh J. Samani Jun Zhang Masato Miyake Seiichi Oyadomari Akihiro Yasue Xuri Li Yun Zhang Yizhi Liu Yihai Cao
author_sort	Carina Fischer
title	A miR-327–FGF10–FGFR2-mediated autocrine signaling mechanism controls white fat browning
title_short	A miR-327–FGF10–FGFR2-mediated autocrine signaling mechanism controls white fat browning
title_full	A miR-327–FGF10–FGFR2-mediated autocrine signaling mechanism controls white fat browning
title_fullStr	A miR-327–FGF10–FGFR2-mediated autocrine signaling mechanism controls white fat browning
title_full_unstemmed	A miR-327–FGF10–FGFR2-mediated autocrine signaling mechanism controls white fat browning
title_sort	mir-327–fgf10–fgfr2-mediated autocrine signaling mechanism controls white fat browning
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/05747f31616e4250bcc20f53bf04d105
work_keys_str_mv	AT carinafischer amir327fgf10fgfr2mediatedautocrinesignalingmechanismcontrolswhitefatbrowning AT takahiroseki amir327fgf10fgfr2mediatedautocrinesignalingmechanismcontrolswhitefatbrowning AT sharonlim amir327fgf10fgfr2mediatedautocrinesignalingmechanismcontrolswhitefatbrowning AT masakinakamura amir327fgf10fgfr2mediatedautocrinesignalingmechanismcontrolswhitefatbrowning AT patrikandersson amir327fgf10fgfr2mediatedautocrinesignalingmechanismcontrolswhitefatbrowning AT yunlongyang amir327fgf10fgfr2mediatedautocrinesignalingmechanismcontrolswhitefatbrowning AT jenniferhonek amir327fgf10fgfr2mediatedautocrinesignalingmechanismcontrolswhitefatbrowning AT yangangwang amir327fgf10fgfr2mediatedautocrinesignalingmechanismcontrolswhitefatbrowning AT yanyangao amir327fgf10fgfr2mediatedautocrinesignalingmechanismcontrolswhitefatbrowning AT fangchen amir327fgf10fgfr2mediatedautocrinesignalingmechanismcontrolswhitefatbrowning AT nileshjsamani amir327fgf10fgfr2mediatedautocrinesignalingmechanismcontrolswhitefatbrowning AT junzhang amir327fgf10fgfr2mediatedautocrinesignalingmechanismcontrolswhitefatbrowning AT masatomiyake amir327fgf10fgfr2mediatedautocrinesignalingmechanismcontrolswhitefatbrowning AT seiichioyadomari amir327fgf10fgfr2mediatedautocrinesignalingmechanismcontrolswhitefatbrowning AT akihiroyasue amir327fgf10fgfr2mediatedautocrinesignalingmechanismcontrolswhitefatbrowning AT xurili amir327fgf10fgfr2mediatedautocrinesignalingmechanismcontrolswhitefatbrowning AT yunzhang amir327fgf10fgfr2mediatedautocrinesignalingmechanismcontrolswhitefatbrowning AT yizhiliu amir327fgf10fgfr2mediatedautocrinesignalingmechanismcontrolswhitefatbrowning AT yihaicao amir327fgf10fgfr2mediatedautocrinesignalingmechanismcontrolswhitefatbrowning AT carinafischer mir327fgf10fgfr2mediatedautocrinesignalingmechanismcontrolswhitefatbrowning AT takahiroseki mir327fgf10fgfr2mediatedautocrinesignalingmechanismcontrolswhitefatbrowning AT sharonlim mir327fgf10fgfr2mediatedautocrinesignalingmechanismcontrolswhitefatbrowning AT masakinakamura mir327fgf10fgfr2mediatedautocrinesignalingmechanismcontrolswhitefatbrowning AT patrikandersson mir327fgf10fgfr2mediatedautocrinesignalingmechanismcontrolswhitefatbrowning AT yunlongyang mir327fgf10fgfr2mediatedautocrinesignalingmechanismcontrolswhitefatbrowning AT jenniferhonek mir327fgf10fgfr2mediatedautocrinesignalingmechanismcontrolswhitefatbrowning AT yangangwang mir327fgf10fgfr2mediatedautocrinesignalingmechanismcontrolswhitefatbrowning AT yanyangao mir327fgf10fgfr2mediatedautocrinesignalingmechanismcontrolswhitefatbrowning AT fangchen mir327fgf10fgfr2mediatedautocrinesignalingmechanismcontrolswhitefatbrowning AT nileshjsamani mir327fgf10fgfr2mediatedautocrinesignalingmechanismcontrolswhitefatbrowning AT junzhang mir327fgf10fgfr2mediatedautocrinesignalingmechanismcontrolswhitefatbrowning AT masatomiyake mir327fgf10fgfr2mediatedautocrinesignalingmechanismcontrolswhitefatbrowning AT seiichioyadomari mir327fgf10fgfr2mediatedautocrinesignalingmechanismcontrolswhitefatbrowning AT akihiroyasue mir327fgf10fgfr2mediatedautocrinesignalingmechanismcontrolswhitefatbrowning AT xurili mir327fgf10fgfr2mediatedautocrinesignalingmechanismcontrolswhitefatbrowning AT yunzhang mir327fgf10fgfr2mediatedautocrinesignalingmechanismcontrolswhitefatbrowning AT yizhiliu mir327fgf10fgfr2mediatedautocrinesignalingmechanismcontrolswhitefatbrowning AT yihaicao mir327fgf10fgfr2mediatedautocrinesignalingmechanismcontrolswhitefatbrowning
_version_	1718385971245875200

A miR-327–FGF10–FGFR2-mediated autocrine signaling mechanism controls white fat browning

Similar Items