A miR-327–FGF10–FGFR2-mediated autocrine signaling mechanism controls white fat browning
White adipocytes can be stimulated to express thermogenic genes in a process known as beiging. Here, the authors show that miR-327 is downregulated during beiging, which releases FGF10 from inhibition and supports beige adipocyte formation via signaling through FGFR2.
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2017
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oai:doaj.org-article:05747f31616e4250bcc20f53bf04d1052021-12-02T15:39:03ZA miR-327–FGF10–FGFR2-mediated autocrine signaling mechanism controls white fat browning10.1038/s41467-017-02158-z2041-1723https://doaj.org/article/05747f31616e4250bcc20f53bf04d1052017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02158-zhttps://doaj.org/toc/2041-1723White adipocytes can be stimulated to express thermogenic genes in a process known as beiging. Here, the authors show that miR-327 is downregulated during beiging, which releases FGF10 from inhibition and supports beige adipocyte formation via signaling through FGFR2.Carina FischerTakahiro SekiSharon LimMasaki NakamuraPatrik AnderssonYunlong YangJennifer HonekYangang WangYanyan GaoFang ChenNilesh J. SamaniJun ZhangMasato MiyakeSeiichi OyadomariAkihiro YasueXuri LiYun ZhangYizhi LiuYihai CaoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-19 (2017) |
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Science Q Carina Fischer Takahiro Seki Sharon Lim Masaki Nakamura Patrik Andersson Yunlong Yang Jennifer Honek Yangang Wang Yanyan Gao Fang Chen Nilesh J. Samani Jun Zhang Masato Miyake Seiichi Oyadomari Akihiro Yasue Xuri Li Yun Zhang Yizhi Liu Yihai Cao A miR-327–FGF10–FGFR2-mediated autocrine signaling mechanism controls white fat browning |
| description |
White adipocytes can be stimulated to express thermogenic genes in a process known as beiging. Here, the authors show that miR-327 is downregulated during beiging, which releases FGF10 from inhibition and supports beige adipocyte formation via signaling through FGFR2. |
| format |
article |
| author |
Carina Fischer Takahiro Seki Sharon Lim Masaki Nakamura Patrik Andersson Yunlong Yang Jennifer Honek Yangang Wang Yanyan Gao Fang Chen Nilesh J. Samani Jun Zhang Masato Miyake Seiichi Oyadomari Akihiro Yasue Xuri Li Yun Zhang Yizhi Liu Yihai Cao |
| author_facet |
Carina Fischer Takahiro Seki Sharon Lim Masaki Nakamura Patrik Andersson Yunlong Yang Jennifer Honek Yangang Wang Yanyan Gao Fang Chen Nilesh J. Samani Jun Zhang Masato Miyake Seiichi Oyadomari Akihiro Yasue Xuri Li Yun Zhang Yizhi Liu Yihai Cao |
| author_sort |
Carina Fischer |
| title |
A miR-327–FGF10–FGFR2-mediated autocrine signaling mechanism controls white fat browning |
| title_short |
A miR-327–FGF10–FGFR2-mediated autocrine signaling mechanism controls white fat browning |
| title_full |
A miR-327–FGF10–FGFR2-mediated autocrine signaling mechanism controls white fat browning |
| title_fullStr |
A miR-327–FGF10–FGFR2-mediated autocrine signaling mechanism controls white fat browning |
| title_full_unstemmed |
A miR-327–FGF10–FGFR2-mediated autocrine signaling mechanism controls white fat browning |
| title_sort |
mir-327–fgf10–fgfr2-mediated autocrine signaling mechanism controls white fat browning |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/05747f31616e4250bcc20f53bf04d105 |
| work_keys_str_mv |
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