Dissection of the Fgf8 regulatory landscape by in vivo CRISPR-editing reveals extensive intra- and inter-enhancer redundancy

Developmental genes are often regulated by multiple elements, yet their relative contribution to gene expression remains poorly understood. Here the authors apply in vivo CRISPR/Cas9 genome engineering to find two distinct regulatory logics directing Fgf8 in the limb apical ectodermal ridge and the...

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Autores principales:	A. Hörnblad, S. Bastide, K. Langenfeld, F. Langa, F. Spitz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/05751165f85045b09795c881fcd806d5
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spelling	oai:doaj.org-article:05751165f85045b09795c881fcd806d52021-12-02T13:51:14ZDissection of the Fgf8 regulatory landscape by in vivo CRISPR-editing reveals extensive intra- and inter-enhancer redundancy10.1038/s41467-020-20714-y2041-1723https://doaj.org/article/05751165f85045b09795c881fcd806d52021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20714-yhttps://doaj.org/toc/2041-1723Developmental genes are often regulated by multiple elements, yet their relative contribution to gene expression remains poorly understood. Here the authors apply in vivo CRISPR/Cas9 genome engineering to find two distinct regulatory logics directing Fgf8 in the limb apical ectodermal ridge and the midbrain-hindbrain boundary.A. HörnbladS. BastideK. LangenfeldF. LangaF. SpitzNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q A. Hörnblad S. Bastide K. Langenfeld F. Langa F. Spitz Dissection of the Fgf8 regulatory landscape by in vivo CRISPR-editing reveals extensive intra- and inter-enhancer redundancy
description	Developmental genes are often regulated by multiple elements, yet their relative contribution to gene expression remains poorly understood. Here the authors apply in vivo CRISPR/Cas9 genome engineering to find two distinct regulatory logics directing Fgf8 in the limb apical ectodermal ridge and the midbrain-hindbrain boundary.
format	article
author	A. Hörnblad S. Bastide K. Langenfeld F. Langa F. Spitz
author_facet	A. Hörnblad S. Bastide K. Langenfeld F. Langa F. Spitz
author_sort	A. Hörnblad
title	Dissection of the Fgf8 regulatory landscape by in vivo CRISPR-editing reveals extensive intra- and inter-enhancer redundancy
title_short	Dissection of the Fgf8 regulatory landscape by in vivo CRISPR-editing reveals extensive intra- and inter-enhancer redundancy
title_full	Dissection of the Fgf8 regulatory landscape by in vivo CRISPR-editing reveals extensive intra- and inter-enhancer redundancy
title_fullStr	Dissection of the Fgf8 regulatory landscape by in vivo CRISPR-editing reveals extensive intra- and inter-enhancer redundancy
title_full_unstemmed	Dissection of the Fgf8 regulatory landscape by in vivo CRISPR-editing reveals extensive intra- and inter-enhancer redundancy
title_sort	dissection of the fgf8 regulatory landscape by in vivo crispr-editing reveals extensive intra- and inter-enhancer redundancy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/05751165f85045b09795c881fcd806d5
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Dissection of the Fgf8 regulatory landscape by in vivo CRISPR-editing reveals extensive intra- and inter-enhancer redundancy

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