The association between neutrophil–lymphocyte ratio and poor outcomes following infant cardiac surgery

Abstract Background Neutrophil–lymphocyte ratio (NLR) is a valuable indicator for evaluating inflammation and adverse outcomes after cardiac surgery. The objective of this study was to evaluate the association of perioperative NLR with clinical outcomes in infants undergoing congenital heart surgery...

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Autores principales:	Peng Gao, Jinping Liu, Xu Wang, Peiyao Zhang, Yu Jin, Liting Bai, Yixuan Li
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Pediatric cardiac surgery Infants Neutrophil–lymphocyte ratio Inflammatory response Poor outcomes Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/0578a6291ef64aaeb58ed5f1ef4f7c4c
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spelling	oai:doaj.org-article:0578a6291ef64aaeb58ed5f1ef4f7c4c2021-11-14T12:07:38ZThe association between neutrophil–lymphocyte ratio and poor outcomes following infant cardiac surgery10.1186/s12872-021-02345-31471-2261https://doaj.org/article/0578a6291ef64aaeb58ed5f1ef4f7c4c2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12872-021-02345-3https://doaj.org/toc/1471-2261Abstract Background Neutrophil–lymphocyte ratio (NLR) is a valuable indicator for evaluating inflammation and adverse outcomes after cardiac surgery. The objective of this study was to evaluate the association of perioperative NLR with clinical outcomes in infants undergoing congenital heart surgery with cardiopulmonary bypass. Methods We performed a retrospective review of 424 consecutive infants (≤ 1 year) undergoing cardiac surgery between January 2019 and September 2019. Neonates (≤ 28 days) and patients with incomplete NLR data were excluded. The study endpoint was a composite of poor outcomes after surgery. We assess the correlation between perioperative NLR and clinical outcomes. A receiver operating characteristic curve and multivariable logistic regression were applied to identify the prognosis performance of postoperative NLR for poor outcomes. Results A total of 68 (16%) infants experienced at least one of the poor outcomes. Postoperative NLR on the third day after the surgery showed the best prognostic significance (AUC = 0.763, 95%CI 0.700–0.826) among perioperative period, with a cut-off value of 2.05. Postoperative NLR was also strongly correlated with mechanical ventilation time, length of ICU and hospital stay (p < 0.001). Multivariable logistic regression revealed that elevated postoperative NLR (OR 3.722, 95%CI 1.895–7.309, p < 0.001) was an independent risk factor for poor outcomes in infants after cardiac surgery. Conclusions Postoperative NLR was correlated with increased mechanical ventilation time, length of ICU and hospital stay. Elevated postoperative NLR was an independent predictor for poor outcomes after cardiac surgery in infants.Peng GaoJinping LiuXu WangPeiyao ZhangYu JinLiting BaiYixuan LiBMCarticlePediatric cardiac surgeryInfantsNeutrophil–lymphocyte ratioInflammatory responsePoor outcomesDiseases of the circulatory (Cardiovascular) systemRC666-701ENBMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pediatric cardiac surgery Infants Neutrophil–lymphocyte ratio Inflammatory response Poor outcomes Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Pediatric cardiac surgery Infants Neutrophil–lymphocyte ratio Inflammatory response Poor outcomes Diseases of the circulatory (Cardiovascular) system RC666-701 Peng Gao Jinping Liu Xu Wang Peiyao Zhang Yu Jin Liting Bai Yixuan Li The association between neutrophil–lymphocyte ratio and poor outcomes following infant cardiac surgery
description	Abstract Background Neutrophil–lymphocyte ratio (NLR) is a valuable indicator for evaluating inflammation and adverse outcomes after cardiac surgery. The objective of this study was to evaluate the association of perioperative NLR with clinical outcomes in infants undergoing congenital heart surgery with cardiopulmonary bypass. Methods We performed a retrospective review of 424 consecutive infants (≤ 1 year) undergoing cardiac surgery between January 2019 and September 2019. Neonates (≤ 28 days) and patients with incomplete NLR data were excluded. The study endpoint was a composite of poor outcomes after surgery. We assess the correlation between perioperative NLR and clinical outcomes. A receiver operating characteristic curve and multivariable logistic regression were applied to identify the prognosis performance of postoperative NLR for poor outcomes. Results A total of 68 (16%) infants experienced at least one of the poor outcomes. Postoperative NLR on the third day after the surgery showed the best prognostic significance (AUC = 0.763, 95%CI 0.700–0.826) among perioperative period, with a cut-off value of 2.05. Postoperative NLR was also strongly correlated with mechanical ventilation time, length of ICU and hospital stay (p < 0.001). Multivariable logistic regression revealed that elevated postoperative NLR (OR 3.722, 95%CI 1.895–7.309, p < 0.001) was an independent risk factor for poor outcomes in infants after cardiac surgery. Conclusions Postoperative NLR was correlated with increased mechanical ventilation time, length of ICU and hospital stay. Elevated postoperative NLR was an independent predictor for poor outcomes after cardiac surgery in infants.
format	article
author	Peng Gao Jinping Liu Xu Wang Peiyao Zhang Yu Jin Liting Bai Yixuan Li
author_facet	Peng Gao Jinping Liu Xu Wang Peiyao Zhang Yu Jin Liting Bai Yixuan Li
author_sort	Peng Gao
title	The association between neutrophil–lymphocyte ratio and poor outcomes following infant cardiac surgery
title_short	The association between neutrophil–lymphocyte ratio and poor outcomes following infant cardiac surgery
title_full	The association between neutrophil–lymphocyte ratio and poor outcomes following infant cardiac surgery
title_fullStr	The association between neutrophil–lymphocyte ratio and poor outcomes following infant cardiac surgery
title_full_unstemmed	The association between neutrophil–lymphocyte ratio and poor outcomes following infant cardiac surgery
title_sort	association between neutrophil–lymphocyte ratio and poor outcomes following infant cardiac surgery
publisher	BMC
publishDate	2021
url	https://doaj.org/article/0578a6291ef64aaeb58ed5f1ef4f7c4c
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The association between neutrophil–lymphocyte ratio and poor outcomes following infant cardiac surgery

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