The use of technical replication for detection of low-level somatic mutations in next-generation sequencing

Somatic mutations of low allele frequencies are often difficult to detect. Here, the authors develop RePlow, a computational method that leverages technical replication for detecting low-level somatic mutations using next-generation sequencing.

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Autores principales:	Junho Kim, Dachan Kim, Jae Seok Lim, Ju Heon Maeng, Hyeonju Son, Hoon-Chul Kang, Hojung Nam, Jeong Ho Lee, Sangwoo Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0578a86addbe436fb5132e2cadf2e2e8
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spelling	oai:doaj.org-article:0578a86addbe436fb5132e2cadf2e2e82021-12-02T15:36:24ZThe use of technical replication for detection of low-level somatic mutations in next-generation sequencing10.1038/s41467-019-09026-y2041-1723https://doaj.org/article/0578a86addbe436fb5132e2cadf2e2e82019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09026-yhttps://doaj.org/toc/2041-1723Somatic mutations of low allele frequencies are often difficult to detect. Here, the authors develop RePlow, a computational method that leverages technical replication for detecting low-level somatic mutations using next-generation sequencing.Junho KimDachan KimJae Seok LimJu Heon MaengHyeonju SonHoon-Chul KangHojung NamJeong Ho LeeSangwoo KimNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Junho Kim Dachan Kim Jae Seok Lim Ju Heon Maeng Hyeonju Son Hoon-Chul Kang Hojung Nam Jeong Ho Lee Sangwoo Kim The use of technical replication for detection of low-level somatic mutations in next-generation sequencing
description	Somatic mutations of low allele frequencies are often difficult to detect. Here, the authors develop RePlow, a computational method that leverages technical replication for detecting low-level somatic mutations using next-generation sequencing.
format	article
author	Junho Kim Dachan Kim Jae Seok Lim Ju Heon Maeng Hyeonju Son Hoon-Chul Kang Hojung Nam Jeong Ho Lee Sangwoo Kim
author_facet	Junho Kim Dachan Kim Jae Seok Lim Ju Heon Maeng Hyeonju Son Hoon-Chul Kang Hojung Nam Jeong Ho Lee Sangwoo Kim
author_sort	Junho Kim
title	The use of technical replication for detection of low-level somatic mutations in next-generation sequencing
title_short	The use of technical replication for detection of low-level somatic mutations in next-generation sequencing
title_full	The use of technical replication for detection of low-level somatic mutations in next-generation sequencing
title_fullStr	The use of technical replication for detection of low-level somatic mutations in next-generation sequencing
title_full_unstemmed	The use of technical replication for detection of low-level somatic mutations in next-generation sequencing
title_sort	use of technical replication for detection of low-level somatic mutations in next-generation sequencing
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0578a86addbe436fb5132e2cadf2e2e8
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The use of technical replication for detection of low-level somatic mutations in next-generation sequencing

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