Single dose of a replication-defective vaccinia virus expressing Zika virus-like particles is protective in mice

Single dose of a replication-defective vaccinia virus expressing Zika virus-like particles is protective in mice

Abstract Zika virus (ZIKV), a flavivirus transmitted primarily by infected mosquitos, can cause neurological symptoms such as Guillian–Barré syndrome and microcephaly. We developed several vaccinia virus (VACV) vaccine candidates for ZIKV based on replication-inducible VACVs (vINDs) expressing ZIKV...

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Autores principales: Brittany Jasperse, Caitlin M. O’Connell, Yuxiang Wang, Paulo H. Verardi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/0579b072da9c435fb3f374dfe50845f0
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