Short- and Long-Term Immunological Responses in Chronic HCV/HIV Co-Infected Compared to HCV Mono-Infected Patients after DAA Therapy

Short- and Long-Term Immunological Responses in Chronic HCV/HIV Co-Infected Compared to HCV Mono-Infected Patients after DAA Therapy

Background: Direct-acting antivirals (DAAs) treatment, although highly efficacious for the treatment of hepatitis C virus (HCV) infection, may not completely reconstitute the HCV-mediated dysregulated immune system, especially in patients co-infected with human immunodeficiency virus (HIV) and HCV....

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Main Authors: Stefania Farcomeni, Sonia Moretti, Caterina Fimiani, Lucia Fontanelli Sulekova, Fenicia Vescio, Leonardo Sernicola, Maria T. Maggiorella, Anna Lisa Remoli, Orietta Picconi, Luciana Mosca, Rozenn Esvan, Elisa Biliotti, Massimo Ciccozzi, Marco Sgarbanti, Gloria Taliani, Alessandra Borsetti
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
HCV infection
HCV/HIV coinfection
DAA direct-acting antivirals
interferon-stimulated gene (ISG) expression
indoleamine 2-3 dioxygenase (IDO) activity
immune activation
Medicine
R
Online Access:https://doaj.org/article/057f838d1acd46889c08a28092015c52
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https://doaj.org/article/057f838d1acd46889c08a28092015c52

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