Dual roles of AMAP1 in the transcriptional regulation and intracellular trafficking of carbonic anhydrase IX

Background: The cell-surface enzyme carbonic anhydrase IX (CAIX/CA9) promotes tumor growth, survival, invasion, and metastasis, mainly via its pH-regulating functions. Owing to its tumor-specific expression, CAIX-targeting antibodies/chemicals are utilized for therapeutic and diagnostic purposes. Ho...

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Autores principales: Mei Horikawa, Hisataka Sabe, Yasuhito Onodera
Formato: article
Lenguaje:EN
Publicado: Elsevier 2022
Materias:
CA9
Acceso en línea:https://doaj.org/article/05815bf77f9c46e689306ffd78f18c81
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