Impact of load-related neural processes on feature binding in visuospatial working memory.

<h4>Background</h4>The capacity of visual working memory (WM) is substantially limited and only a fraction of what we see is maintained as a temporary trace. The process of binding visual features has been proposed as an adaptive means of minimising information demands on WM. However the...

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Autores principales:	Nicole A Kochan, Michael Valenzuela, Melissa J Slavin, Stacey McCraw, Perminder S Sachdev, Michael Breakspear
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/058631b894a340cba629f83672f9008f
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spelling	oai:doaj.org-article:058631b894a340cba629f83672f9008f2021-11-18T06:47:19ZImpact of load-related neural processes on feature binding in visuospatial working memory.1932-620310.1371/journal.pone.0023960https://doaj.org/article/058631b894a340cba629f83672f9008f2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21887352/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The capacity of visual working memory (WM) is substantially limited and only a fraction of what we see is maintained as a temporary trace. The process of binding visual features has been proposed as an adaptive means of minimising information demands on WM. However the neural mechanisms underlying this process, and its modulation by task and load effects, are not well understood.<h4>Objective</h4>To investigate the neural correlates of feature binding and its modulation by WM load during the sequential phases of encoding, maintenance and retrieval.<h4>Methods and findings</h4>18 young healthy participants performed a visuospatial WM task with independent factors of load and feature conjunction (object identity and position) in an event-related functional MRI study. During stimulus encoding, load-invariant conjunction-related activity was observed in left prefrontal cortex and left hippocampus. During maintenance, greater activity for task demands of feature conjunction versus single features, and for increased load was observed in left-sided regions of the superior occipital cortex, precuneus and superior frontal cortex. Where these effects were expressed in overlapping cortical regions, their combined effect was additive. During retrieval, however, an interaction of load and feature conjunction was observed. This modulation of feature conjunction activity under increased load was expressed through greater deactivation in medial structures identified as part of the default mode network.<h4>Conclusions and significance</h4>The relationship between memory load and feature binding qualitatively differed through each phase of the WM task. Of particular interest was the interaction of these factors observed within regions of the default mode network during retrieval which we interpret as suggesting that at low loads, binding processes may be 'automatic' but at higher loads it becomes a resource-intensive process leading to disengagement of activity in this network. These findings provide new insights into how feature binding operates within the capacity-limited WM system.Nicole A KochanMichael ValenzuelaMelissa J SlavinStacey McCrawPerminder S SachdevMichael BreakspearPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 8, p e23960 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nicole A Kochan Michael Valenzuela Melissa J Slavin Stacey McCraw Perminder S Sachdev Michael Breakspear Impact of load-related neural processes on feature binding in visuospatial working memory.
description	<h4>Background</h4>The capacity of visual working memory (WM) is substantially limited and only a fraction of what we see is maintained as a temporary trace. The process of binding visual features has been proposed as an adaptive means of minimising information demands on WM. However the neural mechanisms underlying this process, and its modulation by task and load effects, are not well understood.<h4>Objective</h4>To investigate the neural correlates of feature binding and its modulation by WM load during the sequential phases of encoding, maintenance and retrieval.<h4>Methods and findings</h4>18 young healthy participants performed a visuospatial WM task with independent factors of load and feature conjunction (object identity and position) in an event-related functional MRI study. During stimulus encoding, load-invariant conjunction-related activity was observed in left prefrontal cortex and left hippocampus. During maintenance, greater activity for task demands of feature conjunction versus single features, and for increased load was observed in left-sided regions of the superior occipital cortex, precuneus and superior frontal cortex. Where these effects were expressed in overlapping cortical regions, their combined effect was additive. During retrieval, however, an interaction of load and feature conjunction was observed. This modulation of feature conjunction activity under increased load was expressed through greater deactivation in medial structures identified as part of the default mode network.<h4>Conclusions and significance</h4>The relationship between memory load and feature binding qualitatively differed through each phase of the WM task. Of particular interest was the interaction of these factors observed within regions of the default mode network during retrieval which we interpret as suggesting that at low loads, binding processes may be 'automatic' but at higher loads it becomes a resource-intensive process leading to disengagement of activity in this network. These findings provide new insights into how feature binding operates within the capacity-limited WM system.
format	article
author	Nicole A Kochan Michael Valenzuela Melissa J Slavin Stacey McCraw Perminder S Sachdev Michael Breakspear
author_facet	Nicole A Kochan Michael Valenzuela Melissa J Slavin Stacey McCraw Perminder S Sachdev Michael Breakspear
author_sort	Nicole A Kochan
title	Impact of load-related neural processes on feature binding in visuospatial working memory.
title_short	Impact of load-related neural processes on feature binding in visuospatial working memory.
title_full	Impact of load-related neural processes on feature binding in visuospatial working memory.
title_fullStr	Impact of load-related neural processes on feature binding in visuospatial working memory.
title_full_unstemmed	Impact of load-related neural processes on feature binding in visuospatial working memory.
title_sort	impact of load-related neural processes on feature binding in visuospatial working memory.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/058631b894a340cba629f83672f9008f
work_keys_str_mv	AT nicoleakochan impactofloadrelatedneuralprocessesonfeaturebindinginvisuospatialworkingmemory AT michaelvalenzuela impactofloadrelatedneuralprocessesonfeaturebindinginvisuospatialworkingmemory AT melissajslavin impactofloadrelatedneuralprocessesonfeaturebindinginvisuospatialworkingmemory AT staceymccraw impactofloadrelatedneuralprocessesonfeaturebindinginvisuospatialworkingmemory AT perminderssachdev impactofloadrelatedneuralprocessesonfeaturebindinginvisuospatialworkingmemory AT michaelbreakspear impactofloadrelatedneuralprocessesonfeaturebindinginvisuospatialworkingmemory
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Impact of load-related neural processes on feature binding in visuospatial working memory.

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