Neurons of the dentate molecular layer in the rabbit hippocampus.

The molecular layer of the dentate gyrus appears as the main entrance gate for information into the hippocampus, i.e., where the perforant path axons from the entorhinal cortex synapse onto the spines and dendrites of granule cells. A few dispersed neuronal somata appear intermingled in between and...

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Auteurs principaux:	Francisco J Sancho-Bielsa, Juan D Navarro-López, Gregori Alonso-Llosa, Asunción Molowny, Xavier Ponsoda, Javier Yajeya, Carlos López-García
Format:	article
Langue:	EN
Publié:	Public Library of Science (PLoS) 2012
Sujets:	Medicine R Science Q
Accès en ligne:	https://doaj.org/article/05918a3f6cea4ed593221f39d3e0c855
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spelling	oai:doaj.org-article:05918a3f6cea4ed593221f39d3e0c8552021-11-18T08:09:46ZNeurons of the dentate molecular layer in the rabbit hippocampus.1932-620310.1371/journal.pone.0048470https://doaj.org/article/05918a3f6cea4ed593221f39d3e0c8552012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23144890/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The molecular layer of the dentate gyrus appears as the main entrance gate for information into the hippocampus, i.e., where the perforant path axons from the entorhinal cortex synapse onto the spines and dendrites of granule cells. A few dispersed neuronal somata appear intermingled in between and probably control the flow of information in this area. In rabbits, the number of neurons in the molecular layer increases in the first week of postnatal life and then stabilizes to appear permanent and heterogeneous over the individuals' life span, including old animals. By means of Golgi impregnations, NADPH histochemistry, immunocytochemical stainings and intracellular labelings (lucifer yellow and biocytin injections), eight neuronal morphological types have been detected in the molecular layer of developing adult and old rabbits. Six of them appear as interneurons displaying smooth dendrites and GABA immunoreactivity: those here called as globoid, vertical, small horizontal, large horizontal, inverted pyramidal and polymorphic. Additionally there are two GABA negative types: the sarmentous and ectopic granular neurons. The distribution of the somata and dendritic trees of these neurons shows preferences for a definite sublayer of the molecular layer: small horizontal, sarmentous and inverted pyramidal neurons are preferably found in the outer third of the molecular layer; vertical, globoid and polymorph neurons locate the intermediate third, while large horizontal and ectopic granular neurons occupy the inner third or the juxtagranular molecular layer. Our results reveal substantial differences in the morphology and electrophysiological behaviour between each neuronal archetype in the dentate molecular layer, allowing us to propose a new classification for this neural population.Francisco J Sancho-BielsaJuan D Navarro-LópezGregori Alonso-LlosaAsunción MolownyXavier PonsodaJavier YajeyaCarlos López-GarcíaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e48470 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Francisco J Sancho-Bielsa Juan D Navarro-López Gregori Alonso-Llosa Asunción Molowny Xavier Ponsoda Javier Yajeya Carlos López-García Neurons of the dentate molecular layer in the rabbit hippocampus.
description	The molecular layer of the dentate gyrus appears as the main entrance gate for information into the hippocampus, i.e., where the perforant path axons from the entorhinal cortex synapse onto the spines and dendrites of granule cells. A few dispersed neuronal somata appear intermingled in between and probably control the flow of information in this area. In rabbits, the number of neurons in the molecular layer increases in the first week of postnatal life and then stabilizes to appear permanent and heterogeneous over the individuals' life span, including old animals. By means of Golgi impregnations, NADPH histochemistry, immunocytochemical stainings and intracellular labelings (lucifer yellow and biocytin injections), eight neuronal morphological types have been detected in the molecular layer of developing adult and old rabbits. Six of them appear as interneurons displaying smooth dendrites and GABA immunoreactivity: those here called as globoid, vertical, small horizontal, large horizontal, inverted pyramidal and polymorphic. Additionally there are two GABA negative types: the sarmentous and ectopic granular neurons. The distribution of the somata and dendritic trees of these neurons shows preferences for a definite sublayer of the molecular layer: small horizontal, sarmentous and inverted pyramidal neurons are preferably found in the outer third of the molecular layer; vertical, globoid and polymorph neurons locate the intermediate third, while large horizontal and ectopic granular neurons occupy the inner third or the juxtagranular molecular layer. Our results reveal substantial differences in the morphology and electrophysiological behaviour between each neuronal archetype in the dentate molecular layer, allowing us to propose a new classification for this neural population.
format	article
author	Francisco J Sancho-Bielsa Juan D Navarro-López Gregori Alonso-Llosa Asunción Molowny Xavier Ponsoda Javier Yajeya Carlos López-García
author_facet	Francisco J Sancho-Bielsa Juan D Navarro-López Gregori Alonso-Llosa Asunción Molowny Xavier Ponsoda Javier Yajeya Carlos López-García
author_sort	Francisco J Sancho-Bielsa
title	Neurons of the dentate molecular layer in the rabbit hippocampus.
title_short	Neurons of the dentate molecular layer in the rabbit hippocampus.
title_full	Neurons of the dentate molecular layer in the rabbit hippocampus.
title_fullStr	Neurons of the dentate molecular layer in the rabbit hippocampus.
title_full_unstemmed	Neurons of the dentate molecular layer in the rabbit hippocampus.
title_sort	neurons of the dentate molecular layer in the rabbit hippocampus.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/05918a3f6cea4ed593221f39d3e0c855
work_keys_str_mv	AT franciscojsanchobielsa neuronsofthedentatemolecularlayerintherabbithippocampus AT juandnavarrolopez neuronsofthedentatemolecularlayerintherabbithippocampus AT gregorialonsollosa neuronsofthedentatemolecularlayerintherabbithippocampus AT asuncionmolowny neuronsofthedentatemolecularlayerintherabbithippocampus AT xavierponsoda neuronsofthedentatemolecularlayerintherabbithippocampus AT javieryajeya neuronsofthedentatemolecularlayerintherabbithippocampus AT carloslopezgarcia neuronsofthedentatemolecularlayerintherabbithippocampus
_version_	1718422086809026560

Neurons of the dentate molecular layer in the rabbit hippocampus.

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