Serological response to influenza vaccination among children vaccinated for multiple influenza seasons.

<h4>Background</h4>To evaluate if, among children aged 3 to 15 years, influenza vaccination for multiple seasons affects the proportion sero-protected.<h4>Methodology/principal findings</h4>Participants were 131 healthy children aged 3-15 years. Participants were vaccinated w...

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Autores principales:	Sajjad Rafiq, Margaret L Russell, Richard Webby, Kevin Fonseca, Marek Smieja, Pardeep Singh, Mark Loeb
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/05934a37c2e64ad6a6c05621a990fbfb
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spelling	oai:doaj.org-article:05934a37c2e64ad6a6c05621a990fbfb2021-11-18T08:05:34ZSerological response to influenza vaccination among children vaccinated for multiple influenza seasons.1932-620310.1371/journal.pone.0051498https://doaj.org/article/05934a37c2e64ad6a6c05621a990fbfb2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23240030/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>To evaluate if, among children aged 3 to 15 years, influenza vaccination for multiple seasons affects the proportion sero-protected.<h4>Methodology/principal findings</h4>Participants were 131 healthy children aged 3-15 years. Participants were vaccinated with trivalent inactivated seasonal influenza vaccine (TIV) over the 2005-06, 2006-07 and 2007-8 seasons. Number of seasons vaccinated were categorized as one (2007-08); two (2007-08 and 2006-07 or 2007-08 and 2005-06) or three (2005-06, 2006-07, and 2007-08). Pre- and post-vaccination sera were collected four weeks apart. Antibody titres were determined by hemagglutination inhibition (HAI) assay using antigens to A/Solomon Islands/03/06 (H1N1), A/Wisconsin/67/05 (H3N2) and B/Malaysia/2506/04. The proportions sero-protected were compared by number of seasons vaccinated using cut-points for seroprotection of 1:40 vs. 1:320. The proportions of children sero-protected against H1N1 and H3N2 was high (>85%) regardless of number of seasons vaccinated and regardless of cut-point for seroprotection. For B Malaysia there was no change in proportions sero-protected by number of seasons vaccinated; however the proportions protected were lower than for H1N1 and H3N2, and there was a lower proportion sero-protected when the higher, compared to lower, cut-point was used for sero-protection.<h4>Conclusion/significance</h4>The proportion of children sero-protected is not affected by number of seasons vaccinated.Sajjad RafiqMargaret L RussellRichard WebbyKevin FonsecaMarek SmiejaPardeep SinghMark LoebPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e51498 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sajjad Rafiq Margaret L Russell Richard Webby Kevin Fonseca Marek Smieja Pardeep Singh Mark Loeb Serological response to influenza vaccination among children vaccinated for multiple influenza seasons.
description	<h4>Background</h4>To evaluate if, among children aged 3 to 15 years, influenza vaccination for multiple seasons affects the proportion sero-protected.<h4>Methodology/principal findings</h4>Participants were 131 healthy children aged 3-15 years. Participants were vaccinated with trivalent inactivated seasonal influenza vaccine (TIV) over the 2005-06, 2006-07 and 2007-8 seasons. Number of seasons vaccinated were categorized as one (2007-08); two (2007-08 and 2006-07 or 2007-08 and 2005-06) or three (2005-06, 2006-07, and 2007-08). Pre- and post-vaccination sera were collected four weeks apart. Antibody titres were determined by hemagglutination inhibition (HAI) assay using antigens to A/Solomon Islands/03/06 (H1N1), A/Wisconsin/67/05 (H3N2) and B/Malaysia/2506/04. The proportions sero-protected were compared by number of seasons vaccinated using cut-points for seroprotection of 1:40 vs. 1:320. The proportions of children sero-protected against H1N1 and H3N2 was high (>85%) regardless of number of seasons vaccinated and regardless of cut-point for seroprotection. For B Malaysia there was no change in proportions sero-protected by number of seasons vaccinated; however the proportions protected were lower than for H1N1 and H3N2, and there was a lower proportion sero-protected when the higher, compared to lower, cut-point was used for sero-protection.<h4>Conclusion/significance</h4>The proportion of children sero-protected is not affected by number of seasons vaccinated.
format	article
author	Sajjad Rafiq Margaret L Russell Richard Webby Kevin Fonseca Marek Smieja Pardeep Singh Mark Loeb
author_facet	Sajjad Rafiq Margaret L Russell Richard Webby Kevin Fonseca Marek Smieja Pardeep Singh Mark Loeb
author_sort	Sajjad Rafiq
title	Serological response to influenza vaccination among children vaccinated for multiple influenza seasons.
title_short	Serological response to influenza vaccination among children vaccinated for multiple influenza seasons.
title_full	Serological response to influenza vaccination among children vaccinated for multiple influenza seasons.
title_fullStr	Serological response to influenza vaccination among children vaccinated for multiple influenza seasons.
title_full_unstemmed	Serological response to influenza vaccination among children vaccinated for multiple influenza seasons.
title_sort	serological response to influenza vaccination among children vaccinated for multiple influenza seasons.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/05934a37c2e64ad6a6c05621a990fbfb
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Serological response to influenza vaccination among children vaccinated for multiple influenza seasons.

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