Effects of sintering temperature on surface morphology/microstructure, in vitro degradability, mineralization and osteoblast response to magnesium phosphate as biomedical material

Abstract Magnesium phosphate (MP) was fabricated using a chemical precipitation method, and the biological performances of MP sintered at different temperatures as a biomedical material was investigated. The results indicated that the densification and crystallinity of MP increased as the sintering...

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Autores principales:	Zhiwei Wang, Yuhai Ma, Jie Wei, Xiao Chen, Liehu Cao, Weizong Weng, Quan Li, Han Guo, Jiacan Su
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0594fa6dd819429ea15606a587846c9b
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spelling	oai:doaj.org-article:0594fa6dd819429ea15606a587846c9b2021-12-02T11:52:58ZEffects of sintering temperature on surface morphology/microstructure, in vitro degradability, mineralization and osteoblast response to magnesium phosphate as biomedical material10.1038/s41598-017-00905-22045-2322https://doaj.org/article/0594fa6dd819429ea15606a587846c9b2017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00905-2https://doaj.org/toc/2045-2322Abstract Magnesium phosphate (MP) was fabricated using a chemical precipitation method, and the biological performances of MP sintered at different temperatures as a biomedical material was investigated. The results indicated that the densification and crystallinity of MP increased as the sintering temperature increased. As the sintering temperature increased, the degradability of MP in PBS decreased, and the mineralization ability in SBF significantly increased. In addition, the MP sintered at 800 °C (MP8) possessed the lowest degradability and highest mineralization ability. Moreover, the positive response of MG63 cells to MP significantly increased as the sintering temperature increased, and MP8 significantly promoted the cell spreading, proliferation, differentiation and expressions of osteogenic differentiation-related genes. Faster degradation of MP0 resulted in higher pH environments and ion concentrations, which led to negative responses to osteoblasts. However, the appropriate degradation of MP8 resulted in suitable pH environments and ion concentrations, which led to positive responses to osteoblasts. This study demonstrated that the sintering temperature substantially affected the surface morphology/microstructure, degradability and mineralization, and osteoblasts response to magnesium phosphate.Zhiwei WangYuhai MaJie WeiXiao ChenLiehu CaoWeizong WengQuan LiHan GuoJiacan SuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhiwei Wang Yuhai Ma Jie Wei Xiao Chen Liehu Cao Weizong Weng Quan Li Han Guo Jiacan Su Effects of sintering temperature on surface morphology/microstructure, in vitro degradability, mineralization and osteoblast response to magnesium phosphate as biomedical material
description	Abstract Magnesium phosphate (MP) was fabricated using a chemical precipitation method, and the biological performances of MP sintered at different temperatures as a biomedical material was investigated. The results indicated that the densification and crystallinity of MP increased as the sintering temperature increased. As the sintering temperature increased, the degradability of MP in PBS decreased, and the mineralization ability in SBF significantly increased. In addition, the MP sintered at 800 °C (MP8) possessed the lowest degradability and highest mineralization ability. Moreover, the positive response of MG63 cells to MP significantly increased as the sintering temperature increased, and MP8 significantly promoted the cell spreading, proliferation, differentiation and expressions of osteogenic differentiation-related genes. Faster degradation of MP0 resulted in higher pH environments and ion concentrations, which led to negative responses to osteoblasts. However, the appropriate degradation of MP8 resulted in suitable pH environments and ion concentrations, which led to positive responses to osteoblasts. This study demonstrated that the sintering temperature substantially affected the surface morphology/microstructure, degradability and mineralization, and osteoblasts response to magnesium phosphate.
format	article
author	Zhiwei Wang Yuhai Ma Jie Wei Xiao Chen Liehu Cao Weizong Weng Quan Li Han Guo Jiacan Su
author_facet	Zhiwei Wang Yuhai Ma Jie Wei Xiao Chen Liehu Cao Weizong Weng Quan Li Han Guo Jiacan Su
author_sort	Zhiwei Wang
title	Effects of sintering temperature on surface morphology/microstructure, in vitro degradability, mineralization and osteoblast response to magnesium phosphate as biomedical material
title_short	Effects of sintering temperature on surface morphology/microstructure, in vitro degradability, mineralization and osteoblast response to magnesium phosphate as biomedical material
title_full	Effects of sintering temperature on surface morphology/microstructure, in vitro degradability, mineralization and osteoblast response to magnesium phosphate as biomedical material
title_fullStr	Effects of sintering temperature on surface morphology/microstructure, in vitro degradability, mineralization and osteoblast response to magnesium phosphate as biomedical material
title_full_unstemmed	Effects of sintering temperature on surface morphology/microstructure, in vitro degradability, mineralization and osteoblast response to magnesium phosphate as biomedical material
title_sort	effects of sintering temperature on surface morphology/microstructure, in vitro degradability, mineralization and osteoblast response to magnesium phosphate as biomedical material
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0594fa6dd819429ea15606a587846c9b
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_version_	1718394906526875648

Effects of sintering temperature on surface morphology/microstructure, in vitro degradability, mineralization and osteoblast response to magnesium phosphate as biomedical material

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