The Effect of Radiation and Chemoradiation Therapy on the Head and Neck Mucosal Microbiome: A Review

Radiation (RT) and chemoradiation therapy (CRT) play an essential role in head and neck cancer treatment. However, both cause numerous side effects in the oral cavity, paranasal sinuses, and pharynx, having deleterious consequences on patients’ quality of life. Concomitant with significant advances...

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Autores principales:	Ivry Zagury-Orly, Nader Khaouam, Jonathan Noujaim, Martin Y. Desrosiers, Anastasios Maniakas
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	head and neck cancer microbiome radiation therapy chemoradiation therapy side effects Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/059a46b07a044865bda02e7cfd0aab30
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spelling	oai:doaj.org-article:059a46b07a044865bda02e7cfd0aab302021-12-02T08:27:32ZThe Effect of Radiation and Chemoradiation Therapy on the Head and Neck Mucosal Microbiome: A Review2234-943X10.3389/fonc.2021.784457https://doaj.org/article/059a46b07a044865bda02e7cfd0aab302021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.784457/fullhttps://doaj.org/toc/2234-943XRadiation (RT) and chemoradiation therapy (CRT) play an essential role in head and neck cancer treatment. However, both cause numerous side effects in the oral cavity, paranasal sinuses, and pharynx, having deleterious consequences on patients’ quality of life. Concomitant with significant advances in radiation oncology, much attention has turned to understanding the role of the microbiome in the pathogenesis of treatment-induced tissue toxicity, to ultimately explore microbiome manipulation as a therapeutic intervention. This review sought to discuss current publications investigating the impact of RT and CRT-induced changes on the head and neck microbiome, using culture-independent molecular methods, and propose opportunities for future directions. Based on 13 studies derived from a MEDLINE, EMBASE, and Web of Science search on November 7, 2021, use of molecular methods has uncovered various phyla and genera in the head and neck microbiome, particularly the oral microbiome, not previously known using culture-based methods. However, limited research has investigated the impact of RT/CRT on subsites other than the oral cavity and none of the studies aimed to examine the relationship between the head and neck microbiome and treatment effectiveness. Findings from this review provide helpful insights on our current understanding of treatment-induced oral mucositis, dental plaque, and caries formation and highlight the need for future research to examine the effect of RT/CRT on the sinonasal and oropharyngeal microbiome. In addition, future research should use larger cohorts, examine the impact of the microbiome on treatment response, and study the effect of manipulating the microbiome to overcome therapy resistance.Ivry Zagury-OrlyNader KhaouamJonathan NoujaimMartin Y. DesrosiersMartin Y. DesrosiersAnastasios ManiakasAnastasios ManiakasAnastasios ManiakasFrontiers Media S.A.articlehead and neck cancermicrobiomeradiation therapychemoradiation therapyside effectsNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	head and neck cancer microbiome radiation therapy chemoradiation therapy side effects Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	head and neck cancer microbiome radiation therapy chemoradiation therapy side effects Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Ivry Zagury-Orly Nader Khaouam Jonathan Noujaim Martin Y. Desrosiers Martin Y. Desrosiers Anastasios Maniakas Anastasios Maniakas Anastasios Maniakas The Effect of Radiation and Chemoradiation Therapy on the Head and Neck Mucosal Microbiome: A Review
description	Radiation (RT) and chemoradiation therapy (CRT) play an essential role in head and neck cancer treatment. However, both cause numerous side effects in the oral cavity, paranasal sinuses, and pharynx, having deleterious consequences on patients’ quality of life. Concomitant with significant advances in radiation oncology, much attention has turned to understanding the role of the microbiome in the pathogenesis of treatment-induced tissue toxicity, to ultimately explore microbiome manipulation as a therapeutic intervention. This review sought to discuss current publications investigating the impact of RT and CRT-induced changes on the head and neck microbiome, using culture-independent molecular methods, and propose opportunities for future directions. Based on 13 studies derived from a MEDLINE, EMBASE, and Web of Science search on November 7, 2021, use of molecular methods has uncovered various phyla and genera in the head and neck microbiome, particularly the oral microbiome, not previously known using culture-based methods. However, limited research has investigated the impact of RT/CRT on subsites other than the oral cavity and none of the studies aimed to examine the relationship between the head and neck microbiome and treatment effectiveness. Findings from this review provide helpful insights on our current understanding of treatment-induced oral mucositis, dental plaque, and caries formation and highlight the need for future research to examine the effect of RT/CRT on the sinonasal and oropharyngeal microbiome. In addition, future research should use larger cohorts, examine the impact of the microbiome on treatment response, and study the effect of manipulating the microbiome to overcome therapy resistance.
format	article
author	Ivry Zagury-Orly Nader Khaouam Jonathan Noujaim Martin Y. Desrosiers Martin Y. Desrosiers Anastasios Maniakas Anastasios Maniakas Anastasios Maniakas
author_facet	Ivry Zagury-Orly Nader Khaouam Jonathan Noujaim Martin Y. Desrosiers Martin Y. Desrosiers Anastasios Maniakas Anastasios Maniakas Anastasios Maniakas
author_sort	Ivry Zagury-Orly
title	The Effect of Radiation and Chemoradiation Therapy on the Head and Neck Mucosal Microbiome: A Review
title_short	The Effect of Radiation and Chemoradiation Therapy on the Head and Neck Mucosal Microbiome: A Review
title_full	The Effect of Radiation and Chemoradiation Therapy on the Head and Neck Mucosal Microbiome: A Review
title_fullStr	The Effect of Radiation and Chemoradiation Therapy on the Head and Neck Mucosal Microbiome: A Review
title_full_unstemmed	The Effect of Radiation and Chemoradiation Therapy on the Head and Neck Mucosal Microbiome: A Review
title_sort	effect of radiation and chemoradiation therapy on the head and neck mucosal microbiome: a review
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/059a46b07a044865bda02e7cfd0aab30
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The Effect of Radiation and Chemoradiation Therapy on the Head and Neck Mucosal Microbiome: A Review

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