The role of protease-activated receptor 1 signaling in CD8 T cell effector functions

Summary: CD8 T cells are essential for adaptive immunity against viral infections. Protease activated receptor 1 (PAR1) is expressed by CD8 T cells; however, its role in T cell effector function is not well defined. Here we show that in human CD8 T cells, PAR1 stimulation accelerates calcium mobiliz...

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Autores principales:	Hui Chen, Mindy Smith, Jasmin Herz, Tong Li, Rebecca Hasley, Cecile Le Saout, Ziang Zhu, Jie Cheng, Andres Gronda, José A. Martina, Pablo M. Irusta, Tatiana Karpova, Dorian B. McGavern, Marta Catalfamo
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Molecular biology Immunology Immune response Science Q
Acceso en línea:	https://doaj.org/article/059bb0b455fd410090bd8cec3665286e
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spelling	oai:doaj.org-article:059bb0b455fd410090bd8cec3665286e2021-11-20T05:11:05ZThe role of protease-activated receptor 1 signaling in CD8 T cell effector functions2589-004210.1016/j.isci.2021.103387https://doaj.org/article/059bb0b455fd410090bd8cec3665286e2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589004221013584https://doaj.org/toc/2589-0042Summary: CD8 T cells are essential for adaptive immunity against viral infections. Protease activated receptor 1 (PAR1) is expressed by CD8 T cells; however, its role in T cell effector function is not well defined. Here we show that in human CD8 T cells, PAR1 stimulation accelerates calcium mobilization. Furthermore, PAR1 is involved in cytotoxic T cell function by facilitating granule trafficking via actin polymerization and repositioning of the microtubule organizing center (MTOC) toward the immunological synapse. In vivo, PAR1−/− mice have reduced cytokine-producing T cells in response to a lymphocytic choriomeningitis virus (LCMV) infection and fail to efficiently control the virus. Specific deletion of PAR1 in LCMV GP33-specific CD8 T cells results in reduced expansion and diminished effector function. These data demonstrate that PAR1 plays a role in T cell activation and function, and this pathway could represent a new therapeutic strategy to modulate CD8 T cell effector function.Hui ChenMindy SmithJasmin HerzTong LiRebecca HasleyCecile Le SaoutZiang ZhuJie ChengAndres GrondaJosé A. MartinaPablo M. IrustaTatiana KarpovaDorian B. McGavernMarta CatalfamoElsevierarticleMolecular biologyImmunologyImmune responseScienceQENiScience, Vol 24, Iss 11, Pp 103387- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Molecular biology Immunology Immune response Science Q
spellingShingle	Molecular biology Immunology Immune response Science Q Hui Chen Mindy Smith Jasmin Herz Tong Li Rebecca Hasley Cecile Le Saout Ziang Zhu Jie Cheng Andres Gronda José A. Martina Pablo M. Irusta Tatiana Karpova Dorian B. McGavern Marta Catalfamo The role of protease-activated receptor 1 signaling in CD8 T cell effector functions
description	Summary: CD8 T cells are essential for adaptive immunity against viral infections. Protease activated receptor 1 (PAR1) is expressed by CD8 T cells; however, its role in T cell effector function is not well defined. Here we show that in human CD8 T cells, PAR1 stimulation accelerates calcium mobilization. Furthermore, PAR1 is involved in cytotoxic T cell function by facilitating granule trafficking via actin polymerization and repositioning of the microtubule organizing center (MTOC) toward the immunological synapse. In vivo, PAR1−/− mice have reduced cytokine-producing T cells in response to a lymphocytic choriomeningitis virus (LCMV) infection and fail to efficiently control the virus. Specific deletion of PAR1 in LCMV GP33-specific CD8 T cells results in reduced expansion and diminished effector function. These data demonstrate that PAR1 plays a role in T cell activation and function, and this pathway could represent a new therapeutic strategy to modulate CD8 T cell effector function.
format	article
author	Hui Chen Mindy Smith Jasmin Herz Tong Li Rebecca Hasley Cecile Le Saout Ziang Zhu Jie Cheng Andres Gronda José A. Martina Pablo M. Irusta Tatiana Karpova Dorian B. McGavern Marta Catalfamo
author_facet	Hui Chen Mindy Smith Jasmin Herz Tong Li Rebecca Hasley Cecile Le Saout Ziang Zhu Jie Cheng Andres Gronda José A. Martina Pablo M. Irusta Tatiana Karpova Dorian B. McGavern Marta Catalfamo
author_sort	Hui Chen
title	The role of protease-activated receptor 1 signaling in CD8 T cell effector functions
title_short	The role of protease-activated receptor 1 signaling in CD8 T cell effector functions
title_full	The role of protease-activated receptor 1 signaling in CD8 T cell effector functions
title_fullStr	The role of protease-activated receptor 1 signaling in CD8 T cell effector functions
title_full_unstemmed	The role of protease-activated receptor 1 signaling in CD8 T cell effector functions
title_sort	role of protease-activated receptor 1 signaling in cd8 t cell effector functions
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/059bb0b455fd410090bd8cec3665286e
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The role of protease-activated receptor 1 signaling in CD8 T cell effector functions

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