MAEA is an E3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cells

Haematopoietic stem cells (HSCs) are metabolically quiescent, with balanced myeloid and lymphoid potential. Here the authors show that MAEA is required in HSCs for ubiquitination and downregulation of surface cytokine receptors via autophagy; MAEA loss leads to impaired HSC quiescence and a myelopro...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Qiaozhi Wei, Sandra Pinho, Shuxian Dong, Halley Pierce, Huihui Li, Fumio Nakahara, Jianing Xu, Chunliang Xu, Philip E. Boulais, Dachuan Zhang, Maria Maryanovich, Ana Maria Cuervo, Paul S. Frenette
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/059f791163b643c18f32b07f9e23c4f7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:059f791163b643c18f32b07f9e23c4f7
record_format	dspace
spelling	oai:doaj.org-article:059f791163b643c18f32b07f9e23c4f72021-12-02T16:51:30ZMAEA is an E3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cells10.1038/s41467-021-22749-12041-1723https://doaj.org/article/059f791163b643c18f32b07f9e23c4f72021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22749-1https://doaj.org/toc/2041-1723Haematopoietic stem cells (HSCs) are metabolically quiescent, with balanced myeloid and lymphoid potential. Here the authors show that MAEA is required in HSCs for ubiquitination and downregulation of surface cytokine receptors via autophagy; MAEA loss leads to impaired HSC quiescence and a myeloproliferative disorder.Qiaozhi WeiSandra PinhoShuxian DongHalley PierceHuihui LiFumio NakaharaJianing XuChunliang XuPhilip E. BoulaisDachuan ZhangMaria MaryanovichAna Maria CuervoPaul S. FrenetteNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qiaozhi Wei Sandra Pinho Shuxian Dong Halley Pierce Huihui Li Fumio Nakahara Jianing Xu Chunliang Xu Philip E. Boulais Dachuan Zhang Maria Maryanovich Ana Maria Cuervo Paul S. Frenette MAEA is an E3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cells
description	Haematopoietic stem cells (HSCs) are metabolically quiescent, with balanced myeloid and lymphoid potential. Here the authors show that MAEA is required in HSCs for ubiquitination and downregulation of surface cytokine receptors via autophagy; MAEA loss leads to impaired HSC quiescence and a myeloproliferative disorder.
format	article
author	Qiaozhi Wei Sandra Pinho Shuxian Dong Halley Pierce Huihui Li Fumio Nakahara Jianing Xu Chunliang Xu Philip E. Boulais Dachuan Zhang Maria Maryanovich Ana Maria Cuervo Paul S. Frenette
author_facet	Qiaozhi Wei Sandra Pinho Shuxian Dong Halley Pierce Huihui Li Fumio Nakahara Jianing Xu Chunliang Xu Philip E. Boulais Dachuan Zhang Maria Maryanovich Ana Maria Cuervo Paul S. Frenette
author_sort	Qiaozhi Wei
title	MAEA is an E3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cells
title_short	MAEA is an E3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cells
title_full	MAEA is an E3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cells
title_fullStr	MAEA is an E3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cells
title_full_unstemmed	MAEA is an E3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cells
title_sort	maea is an e3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/059f791163b643c18f32b07f9e23c4f7
work_keys_str_mv	AT qiaozhiwei maeaisane3ubiquitinligasepromotingautophagyandmaintenanceofhaematopoieticstemcells AT sandrapinho maeaisane3ubiquitinligasepromotingautophagyandmaintenanceofhaematopoieticstemcells AT shuxiandong maeaisane3ubiquitinligasepromotingautophagyandmaintenanceofhaematopoieticstemcells AT halleypierce maeaisane3ubiquitinligasepromotingautophagyandmaintenanceofhaematopoieticstemcells AT huihuili maeaisane3ubiquitinligasepromotingautophagyandmaintenanceofhaematopoieticstemcells AT fumionakahara maeaisane3ubiquitinligasepromotingautophagyandmaintenanceofhaematopoieticstemcells AT jianingxu maeaisane3ubiquitinligasepromotingautophagyandmaintenanceofhaematopoieticstemcells AT chunliangxu maeaisane3ubiquitinligasepromotingautophagyandmaintenanceofhaematopoieticstemcells AT philipeboulais maeaisane3ubiquitinligasepromotingautophagyandmaintenanceofhaematopoieticstemcells AT dachuanzhang maeaisane3ubiquitinligasepromotingautophagyandmaintenanceofhaematopoieticstemcells AT mariamaryanovich maeaisane3ubiquitinligasepromotingautophagyandmaintenanceofhaematopoieticstemcells AT anamariacuervo maeaisane3ubiquitinligasepromotingautophagyandmaintenanceofhaematopoieticstemcells AT paulsfrenette maeaisane3ubiquitinligasepromotingautophagyandmaintenanceofhaematopoieticstemcells
_version_	1718382899569360896

MAEA is an E3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cells

Ejemplares similares