MAEA is an E3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cells

Haematopoietic stem cells (HSCs) are metabolically quiescent, with balanced myeloid and lymphoid potential. Here the authors show that MAEA is required in HSCs for ubiquitination and downregulation of surface cytokine receptors via autophagy; MAEA loss leads to impaired HSC quiescence and a myelopro...

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Auteurs principaux:	Qiaozhi Wei, Sandra Pinho, Shuxian Dong, Halley Pierce, Huihui Li, Fumio Nakahara, Jianing Xu, Chunliang Xu, Philip E. Boulais, Dachuan Zhang, Maria Maryanovich, Ana Maria Cuervo, Paul S. Frenette
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/059f791163b643c18f32b07f9e23c4f7
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spelling	oai:doaj.org-article:059f791163b643c18f32b07f9e23c4f72021-12-02T16:51:30ZMAEA is an E3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cells10.1038/s41467-021-22749-12041-1723https://doaj.org/article/059f791163b643c18f32b07f9e23c4f72021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22749-1https://doaj.org/toc/2041-1723Haematopoietic stem cells (HSCs) are metabolically quiescent, with balanced myeloid and lymphoid potential. Here the authors show that MAEA is required in HSCs for ubiquitination and downregulation of surface cytokine receptors via autophagy; MAEA loss leads to impaired HSC quiescence and a myeloproliferative disorder.Qiaozhi WeiSandra PinhoShuxian DongHalley PierceHuihui LiFumio NakaharaJianing XuChunliang XuPhilip E. BoulaisDachuan ZhangMaria MaryanovichAna Maria CuervoPaul S. FrenetteNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qiaozhi Wei Sandra Pinho Shuxian Dong Halley Pierce Huihui Li Fumio Nakahara Jianing Xu Chunliang Xu Philip E. Boulais Dachuan Zhang Maria Maryanovich Ana Maria Cuervo Paul S. Frenette MAEA is an E3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cells
description	Haematopoietic stem cells (HSCs) are metabolically quiescent, with balanced myeloid and lymphoid potential. Here the authors show that MAEA is required in HSCs for ubiquitination and downregulation of surface cytokine receptors via autophagy; MAEA loss leads to impaired HSC quiescence and a myeloproliferative disorder.
format	article
author	Qiaozhi Wei Sandra Pinho Shuxian Dong Halley Pierce Huihui Li Fumio Nakahara Jianing Xu Chunliang Xu Philip E. Boulais Dachuan Zhang Maria Maryanovich Ana Maria Cuervo Paul S. Frenette
author_facet	Qiaozhi Wei Sandra Pinho Shuxian Dong Halley Pierce Huihui Li Fumio Nakahara Jianing Xu Chunliang Xu Philip E. Boulais Dachuan Zhang Maria Maryanovich Ana Maria Cuervo Paul S. Frenette
author_sort	Qiaozhi Wei
title	MAEA is an E3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cells
title_short	MAEA is an E3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cells
title_full	MAEA is an E3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cells
title_fullStr	MAEA is an E3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cells
title_full_unstemmed	MAEA is an E3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cells
title_sort	maea is an e3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/059f791163b643c18f32b07f9e23c4f7
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MAEA is an E3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cells

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