The association of systemic microvascular changes with lung function and lung density: a cross-sectional study.

Smoking causes endothelial dysfunction and systemic microvascular disease with resultant end-organ damage in the kidneys, eyes and heart. Little is known about microvascular changes in smoking-related lung disease. We tested if microvascular changes in the retina, kidneys and heart were associated w...

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Autores principales:	Bianca Harris, Ronald Klein, Michael Jerosch-Herold, Eric A Hoffman, Firas S Ahmed, David R Jacobs, Barbara E K Klein, Tien Y Wong, Joao A C Lima, Mary Frances Cotch, R Graham Barr
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/05a047ef14624fefb01f987aa056c52a
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spelling	oai:doaj.org-article:05a047ef14624fefb01f987aa056c52a2021-11-18T08:04:26ZThe association of systemic microvascular changes with lung function and lung density: a cross-sectional study.1932-620310.1371/journal.pone.0050224https://doaj.org/article/05a047ef14624fefb01f987aa056c52a2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23284634/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Smoking causes endothelial dysfunction and systemic microvascular disease with resultant end-organ damage in the kidneys, eyes and heart. Little is known about microvascular changes in smoking-related lung disease. We tested if microvascular changes in the retina, kidneys and heart were associated with obstructive spirometry and low lung density on computed tomography. The Multi-Ethnic Study of Atherosclerosis recruited participants age 45-84 years without clinical cardiovascular disease. Measures of microvascular function included retinal arteriolar and venular caliber, urine albumin-to-creatinine ratio and, in a subset, myocardial blood flow on magnetic resonance imaging. Spirometry was measured following ATS/ERS guidelines. Low attenuation areas (LAA) were measured on lung fields of cardiac computed tomograms. Regression models adjusted for pulmonary and cardiac risk factors, medications and body size. Among 3,397 participants, retinal venular caliber was inversely associated with forced expiratory volume in one second (FEV(1)) (P<0.001) and FEV(1)/forced vital capacity (FVC) ratio (P = 0.04). Albumin-to-creatinine ratio was inversely associated with FEV(1) (P = 0.002) but not FEV(1)/FVC. Myocardial blood flow (n = 126) was associated with lower FEV(1) (P = 0.02), lower FEV(1)/FVC (P = 0.001) and greater percentage LAA (P = 0.04). Associations were of greater magnitude among smokers. Low lung function was associated with microvascular changes in the retina, kidneys and heart, and low lung density was associated with impaired myocardial microvascular perfusion. These cross-sectional results suggest that microvascular damage with end-organ dysfunction in all circulations may pertain to the lung, that lung dysfunction may contribute to systemic microvascular disease, or that there may be a shared predisposition.Bianca HarrisRonald KleinMichael Jerosch-HeroldEric A HoffmanFiras S AhmedDavid R JacobsBarbara E K KleinTien Y WongJoao A C LimaMary Frances CotchR Graham BarrPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e50224 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bianca Harris Ronald Klein Michael Jerosch-Herold Eric A Hoffman Firas S Ahmed David R Jacobs Barbara E K Klein Tien Y Wong Joao A C Lima Mary Frances Cotch R Graham Barr The association of systemic microvascular changes with lung function and lung density: a cross-sectional study.
description	Smoking causes endothelial dysfunction and systemic microvascular disease with resultant end-organ damage in the kidneys, eyes and heart. Little is known about microvascular changes in smoking-related lung disease. We tested if microvascular changes in the retina, kidneys and heart were associated with obstructive spirometry and low lung density on computed tomography. The Multi-Ethnic Study of Atherosclerosis recruited participants age 45-84 years without clinical cardiovascular disease. Measures of microvascular function included retinal arteriolar and venular caliber, urine albumin-to-creatinine ratio and, in a subset, myocardial blood flow on magnetic resonance imaging. Spirometry was measured following ATS/ERS guidelines. Low attenuation areas (LAA) were measured on lung fields of cardiac computed tomograms. Regression models adjusted for pulmonary and cardiac risk factors, medications and body size. Among 3,397 participants, retinal venular caliber was inversely associated with forced expiratory volume in one second (FEV(1)) (P<0.001) and FEV(1)/forced vital capacity (FVC) ratio (P = 0.04). Albumin-to-creatinine ratio was inversely associated with FEV(1) (P = 0.002) but not FEV(1)/FVC. Myocardial blood flow (n = 126) was associated with lower FEV(1) (P = 0.02), lower FEV(1)/FVC (P = 0.001) and greater percentage LAA (P = 0.04). Associations were of greater magnitude among smokers. Low lung function was associated with microvascular changes in the retina, kidneys and heart, and low lung density was associated with impaired myocardial microvascular perfusion. These cross-sectional results suggest that microvascular damage with end-organ dysfunction in all circulations may pertain to the lung, that lung dysfunction may contribute to systemic microvascular disease, or that there may be a shared predisposition.
format	article
author	Bianca Harris Ronald Klein Michael Jerosch-Herold Eric A Hoffman Firas S Ahmed David R Jacobs Barbara E K Klein Tien Y Wong Joao A C Lima Mary Frances Cotch R Graham Barr
author_facet	Bianca Harris Ronald Klein Michael Jerosch-Herold Eric A Hoffman Firas S Ahmed David R Jacobs Barbara E K Klein Tien Y Wong Joao A C Lima Mary Frances Cotch R Graham Barr
author_sort	Bianca Harris
title	The association of systemic microvascular changes with lung function and lung density: a cross-sectional study.
title_short	The association of systemic microvascular changes with lung function and lung density: a cross-sectional study.
title_full	The association of systemic microvascular changes with lung function and lung density: a cross-sectional study.
title_fullStr	The association of systemic microvascular changes with lung function and lung density: a cross-sectional study.
title_full_unstemmed	The association of systemic microvascular changes with lung function and lung density: a cross-sectional study.
title_sort	association of systemic microvascular changes with lung function and lung density: a cross-sectional study.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/05a047ef14624fefb01f987aa056c52a
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The association of systemic microvascular changes with lung function and lung density: a cross-sectional study.

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