The Prediction of Metastases of Lateral Cervical Lymph Node in Medullary Thyroid Carcinoma
PurposeDevelopment and validation of a nomogram for the prediction of lateral lymph node metastasis (LLNM) in medullary thyroid carcinoma (MTC).MethodsWe retrospectively reviewed the clinical features of patients with MTC in the Surveillance, Epidemiology, and End Results (SEER) database between 201...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:05a26fa1446e449ca3068d37ab2bef6f2021-11-17T07:05:02ZThe Prediction of Metastases of Lateral Cervical Lymph Node in Medullary Thyroid Carcinoma1664-239210.3389/fendo.2021.741289https://doaj.org/article/05a26fa1446e449ca3068d37ab2bef6f2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.741289/fullhttps://doaj.org/toc/1664-2392PurposeDevelopment and validation of a nomogram for the prediction of lateral lymph node metastasis (LLNM) in medullary thyroid carcinoma (MTC).MethodsWe retrospectively reviewed the clinical features of patients with MTC in the Surveillance, Epidemiology, and End Results (SEER) database between 2010 and 2017 and in our Department of Surgical Oncology, Hangzhou First People’s Hospital between 2009 and 2019. The log‐rank test was used to compare the difference in the Kaplan–Meier (K–M) curves in recurrence and survival. The nomogram was developed to predict the risk of LLNM in MTC patients. The prediction efficiency of the predictive model was assessed by area under the curve (AUC) and concordance index (C-index) and calibration curves. Decision curve analysis (DCA) was performed to determine the clinic value of the predictive model.ResultA total of 714 patients in the SEER database and 35 patients in our department were enrolled in our study. Patients with LLNM had worse recurrence rate and cancer-specific survival (CSS) compared with patients without LLNM. Five clinical characteristics including sex, tumor size, multifocality, extrathyroidal extension, and distant metastasis were identified to be associated with LLNM in MTC patients, which were used to develop a nomogram. Our prediction model had satisfied discrimination with a C-index of 0.825, supported by both training set and internal testing set with a C-index of 0.825, and 0.816, respectively. DCA was further made to evaluate the clinical utility of this nomogram for predicting LLNM.ConclusionsMale sex, tumor size >38mm, multifocality, extrathyroidal extension, and distant metastasis in MTC patients were significant risk factors for predicting LLNM.Tian-Han ZhouLing-Qian ZhaoYu ZhangYu ZhangFan WuKai-Ning LuLin-Lin MaoLin-Lin MaoKe-Cheng JiangDing-Cun LuoDing-Cun LuoFrontiers Media S.A.articlelateral lymph node metastasisnomogrammedullary thyroid carcinomaSEERpredictionDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021) |
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lateral lymph node metastasis nomogram medullary thyroid carcinoma SEER prediction Diseases of the endocrine glands. Clinical endocrinology RC648-665 |
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lateral lymph node metastasis nomogram medullary thyroid carcinoma SEER prediction Diseases of the endocrine glands. Clinical endocrinology RC648-665 Tian-Han Zhou Ling-Qian Zhao Yu Zhang Yu Zhang Fan Wu Kai-Ning Lu Lin-Lin Mao Lin-Lin Mao Ke-Cheng Jiang Ding-Cun Luo Ding-Cun Luo The Prediction of Metastases of Lateral Cervical Lymph Node in Medullary Thyroid Carcinoma |
| description |
PurposeDevelopment and validation of a nomogram for the prediction of lateral lymph node metastasis (LLNM) in medullary thyroid carcinoma (MTC).MethodsWe retrospectively reviewed the clinical features of patients with MTC in the Surveillance, Epidemiology, and End Results (SEER) database between 2010 and 2017 and in our Department of Surgical Oncology, Hangzhou First People’s Hospital between 2009 and 2019. The log‐rank test was used to compare the difference in the Kaplan–Meier (K–M) curves in recurrence and survival. The nomogram was developed to predict the risk of LLNM in MTC patients. The prediction efficiency of the predictive model was assessed by area under the curve (AUC) and concordance index (C-index) and calibration curves. Decision curve analysis (DCA) was performed to determine the clinic value of the predictive model.ResultA total of 714 patients in the SEER database and 35 patients in our department were enrolled in our study. Patients with LLNM had worse recurrence rate and cancer-specific survival (CSS) compared with patients without LLNM. Five clinical characteristics including sex, tumor size, multifocality, extrathyroidal extension, and distant metastasis were identified to be associated with LLNM in MTC patients, which were used to develop a nomogram. Our prediction model had satisfied discrimination with a C-index of 0.825, supported by both training set and internal testing set with a C-index of 0.825, and 0.816, respectively. DCA was further made to evaluate the clinical utility of this nomogram for predicting LLNM.ConclusionsMale sex, tumor size >38mm, multifocality, extrathyroidal extension, and distant metastasis in MTC patients were significant risk factors for predicting LLNM. |
| format |
article |
| author |
Tian-Han Zhou Ling-Qian Zhao Yu Zhang Yu Zhang Fan Wu Kai-Ning Lu Lin-Lin Mao Lin-Lin Mao Ke-Cheng Jiang Ding-Cun Luo Ding-Cun Luo |
| author_facet |
Tian-Han Zhou Ling-Qian Zhao Yu Zhang Yu Zhang Fan Wu Kai-Ning Lu Lin-Lin Mao Lin-Lin Mao Ke-Cheng Jiang Ding-Cun Luo Ding-Cun Luo |
| author_sort |
Tian-Han Zhou |
| title |
The Prediction of Metastases of Lateral Cervical Lymph Node in Medullary Thyroid Carcinoma |
| title_short |
The Prediction of Metastases of Lateral Cervical Lymph Node in Medullary Thyroid Carcinoma |
| title_full |
The Prediction of Metastases of Lateral Cervical Lymph Node in Medullary Thyroid Carcinoma |
| title_fullStr |
The Prediction of Metastases of Lateral Cervical Lymph Node in Medullary Thyroid Carcinoma |
| title_full_unstemmed |
The Prediction of Metastases of Lateral Cervical Lymph Node in Medullary Thyroid Carcinoma |
| title_sort |
prediction of metastases of lateral cervical lymph node in medullary thyroid carcinoma |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/05a26fa1446e449ca3068d37ab2bef6f |
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