Sex Differences in Cognitive Decline in Subjects with High Likelihood of Mild Cognitive Impairment due to Alzheimer’s disease

Abstract Sex differences in Alzheimer’s disease (AD) biology and progression are not yet fully characterized. The goal of this study is to examine the effect of sex on cognitive progression in subjects with high likelihood of mild cognitive impairment (MCI) due to Alzheimer’s and followed up to 10 y...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Dongwha Sohn, Katie Shpanskaya, Joseph E. Lucas, Jeffrey R. Petrella, Andrew J. Saykin, Rudolph E. Tanzi, Nagiza F. Samatova, P. Murali Doraiswamy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/05a3d5f6795f435bbfb4b5fddc165472
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:05a3d5f6795f435bbfb4b5fddc165472
record_format	dspace
spelling	oai:doaj.org-article:05a3d5f6795f435bbfb4b5fddc1654722021-12-02T16:07:51ZSex Differences in Cognitive Decline in Subjects with High Likelihood of Mild Cognitive Impairment due to Alzheimer’s disease10.1038/s41598-018-25377-w2045-2322https://doaj.org/article/05a3d5f6795f435bbfb4b5fddc1654722018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25377-whttps://doaj.org/toc/2045-2322Abstract Sex differences in Alzheimer’s disease (AD) biology and progression are not yet fully characterized. The goal of this study is to examine the effect of sex on cognitive progression in subjects with high likelihood of mild cognitive impairment (MCI) due to Alzheimer’s and followed up to 10 years in the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Cerebrospinal fluid total-tau and amyloid-beta (Aβ42) ratio values were used to sub-classify 559 MCI subjects (216 females, 343 males) as having “high” or “low” likelihood for MCI due to Alzheimer’s. Data were analyzed using mixed-effects models incorporating all follow-ups. The worsening from baseline in Alzheimer’s Disease Assessment Scale-Cognitive score (mean, SD) (9 ± 12) in subjects with high likelihood of MCI due to Alzheimer’s was markedly greater than that in subjects with low likelihood (1 ± 6, p < 0.0001). Among MCI due to AD subjects, the mean worsening in cognitive score was significantly greater in females (11.58 ± 14) than in males (6.87 ± 11, p = 0.006). Our findings highlight the need to further investigate these findings in other populations and develop sex specific timelines for Alzheimer’s disease progression.Dongwha SohnKatie ShpanskayaJoseph E. LucasJeffrey R. PetrellaAndrew J. SaykinRudolph E. TanziNagiza F. SamatovaP. Murali DoraiswamyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dongwha Sohn Katie Shpanskaya Joseph E. Lucas Jeffrey R. Petrella Andrew J. Saykin Rudolph E. Tanzi Nagiza F. Samatova P. Murali Doraiswamy Sex Differences in Cognitive Decline in Subjects with High Likelihood of Mild Cognitive Impairment due to Alzheimer’s disease
description	Abstract Sex differences in Alzheimer’s disease (AD) biology and progression are not yet fully characterized. The goal of this study is to examine the effect of sex on cognitive progression in subjects with high likelihood of mild cognitive impairment (MCI) due to Alzheimer’s and followed up to 10 years in the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Cerebrospinal fluid total-tau and amyloid-beta (Aβ42) ratio values were used to sub-classify 559 MCI subjects (216 females, 343 males) as having “high” or “low” likelihood for MCI due to Alzheimer’s. Data were analyzed using mixed-effects models incorporating all follow-ups. The worsening from baseline in Alzheimer’s Disease Assessment Scale-Cognitive score (mean, SD) (9 ± 12) in subjects with high likelihood of MCI due to Alzheimer’s was markedly greater than that in subjects with low likelihood (1 ± 6, p < 0.0001). Among MCI due to AD subjects, the mean worsening in cognitive score was significantly greater in females (11.58 ± 14) than in males (6.87 ± 11, p = 0.006). Our findings highlight the need to further investigate these findings in other populations and develop sex specific timelines for Alzheimer’s disease progression.
format	article
author	Dongwha Sohn Katie Shpanskaya Joseph E. Lucas Jeffrey R. Petrella Andrew J. Saykin Rudolph E. Tanzi Nagiza F. Samatova P. Murali Doraiswamy
author_facet	Dongwha Sohn Katie Shpanskaya Joseph E. Lucas Jeffrey R. Petrella Andrew J. Saykin Rudolph E. Tanzi Nagiza F. Samatova P. Murali Doraiswamy
author_sort	Dongwha Sohn
title	Sex Differences in Cognitive Decline in Subjects with High Likelihood of Mild Cognitive Impairment due to Alzheimer’s disease
title_short	Sex Differences in Cognitive Decline in Subjects with High Likelihood of Mild Cognitive Impairment due to Alzheimer’s disease
title_full	Sex Differences in Cognitive Decline in Subjects with High Likelihood of Mild Cognitive Impairment due to Alzheimer’s disease
title_fullStr	Sex Differences in Cognitive Decline in Subjects with High Likelihood of Mild Cognitive Impairment due to Alzheimer’s disease
title_full_unstemmed	Sex Differences in Cognitive Decline in Subjects with High Likelihood of Mild Cognitive Impairment due to Alzheimer’s disease
title_sort	sex differences in cognitive decline in subjects with high likelihood of mild cognitive impairment due to alzheimer’s disease
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/05a3d5f6795f435bbfb4b5fddc165472
work_keys_str_mv	AT dongwhasohn sexdifferencesincognitivedeclineinsubjectswithhighlikelihoodofmildcognitiveimpairmentduetoalzheimersdisease AT katieshpanskaya sexdifferencesincognitivedeclineinsubjectswithhighlikelihoodofmildcognitiveimpairmentduetoalzheimersdisease AT josephelucas sexdifferencesincognitivedeclineinsubjectswithhighlikelihoodofmildcognitiveimpairmentduetoalzheimersdisease AT jeffreyrpetrella sexdifferencesincognitivedeclineinsubjectswithhighlikelihoodofmildcognitiveimpairmentduetoalzheimersdisease AT andrewjsaykin sexdifferencesincognitivedeclineinsubjectswithhighlikelihoodofmildcognitiveimpairmentduetoalzheimersdisease AT rudolphetanzi sexdifferencesincognitivedeclineinsubjectswithhighlikelihoodofmildcognitiveimpairmentduetoalzheimersdisease AT nagizafsamatova sexdifferencesincognitivedeclineinsubjectswithhighlikelihoodofmildcognitiveimpairmentduetoalzheimersdisease AT pmuralidoraiswamy sexdifferencesincognitivedeclineinsubjectswithhighlikelihoodofmildcognitiveimpairmentduetoalzheimersdisease
_version_	1718384697812189184

Sex Differences in Cognitive Decline in Subjects with High Likelihood of Mild Cognitive Impairment due to Alzheimer’s disease

Ejemplares similares