The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia
mTORC1 expression is increased during ageing of muscle, and on the other hand, its activation promotes muscle hypertrophy. Here, the authors assess whether mTORC1 has positive or negative effects on ageing, and show that its long-term inhibition preserves muscle mass and function and neuromuscular j...
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Nature Portfolio
2020
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oai:doaj.org-article:05a591c692df4b149c92e816d59050722021-12-02T14:55:15ZThe neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia10.1038/s41467-020-18140-12041-1723https://doaj.org/article/05a591c692df4b149c92e816d59050722020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18140-1https://doaj.org/toc/2041-1723mTORC1 expression is increased during ageing of muscle, and on the other hand, its activation promotes muscle hypertrophy. Here, the authors assess whether mTORC1 has positive or negative effects on ageing, and show that its long-term inhibition preserves muscle mass and function and neuromuscular junction integrity, whereas muscle-specific activation is associated with sarcopenia.Daniel J. HamAnastasiya BörschShuo LinMarco ThürkaufMartin WeihrauchJudith R. ReinhardJulien DelezieFabienne BattilanaXueyong WangMarco S. KaiserMaitea GuridiMichael SinnreichMark M. RichNitish MittalLionel A. TintignacChristoph HandschinMihaela ZavolanMarkus A. RüeggNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-21 (2020) |
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| topic |
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Science Q Daniel J. Ham Anastasiya Börsch Shuo Lin Marco Thürkauf Martin Weihrauch Judith R. Reinhard Julien Delezie Fabienne Battilana Xueyong Wang Marco S. Kaiser Maitea Guridi Michael Sinnreich Mark M. Rich Nitish Mittal Lionel A. Tintignac Christoph Handschin Mihaela Zavolan Markus A. Rüegg The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia |
| description |
mTORC1 expression is increased during ageing of muscle, and on the other hand, its activation promotes muscle hypertrophy. Here, the authors assess whether mTORC1 has positive or negative effects on ageing, and show that its long-term inhibition preserves muscle mass and function and neuromuscular junction integrity, whereas muscle-specific activation is associated with sarcopenia. |
| format |
article |
| author |
Daniel J. Ham Anastasiya Börsch Shuo Lin Marco Thürkauf Martin Weihrauch Judith R. Reinhard Julien Delezie Fabienne Battilana Xueyong Wang Marco S. Kaiser Maitea Guridi Michael Sinnreich Mark M. Rich Nitish Mittal Lionel A. Tintignac Christoph Handschin Mihaela Zavolan Markus A. Rüegg |
| author_facet |
Daniel J. Ham Anastasiya Börsch Shuo Lin Marco Thürkauf Martin Weihrauch Judith R. Reinhard Julien Delezie Fabienne Battilana Xueyong Wang Marco S. Kaiser Maitea Guridi Michael Sinnreich Mark M. Rich Nitish Mittal Lionel A. Tintignac Christoph Handschin Mihaela Zavolan Markus A. Rüegg |
| author_sort |
Daniel J. Ham |
| title |
The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia |
| title_short |
The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia |
| title_full |
The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia |
| title_fullStr |
The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia |
| title_full_unstemmed |
The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia |
| title_sort |
neuromuscular junction is a focal point of mtorc1 signaling in sarcopenia |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/05a591c692df4b149c92e816d5905072 |
| work_keys_str_mv |
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