Transforming growth factor β1 induces the expression of collagen type I by DNA methylation in cardiac fibroblasts.

Transforming growth factor β1 induces the expression of collagen type I by DNA methylation in cardiac fibroblasts.

Transforming growth factor-beta (TGF-β), a key mediator of cardiac fibroblast activation, has a major influence on collagen type I production. However, the epigenetic mechanisms by which TGF-β induces collagen type I alpha 1 (COL1A1) expression are not fully understood. This study was designed to ex...

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Autores principales: Xiaodong Pan, Zhongpu Chen, Rong Huang, Yuyu Yao, Genshan Ma
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/05a7662add64430fa4d1950a5762781e
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