CREB controls cortical circuit plasticity and functional recovery after stroke

Increasing excitability in the peri-infarct area enhances motor recovery after stroke. Here the authors show that expressing CREB, a transcription factor known for its role in synaptic plasticity, or increasing activity of CREB-expressing cells near the stroke site improves recovery in an effect tha...

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Main Authors:	L. Caracciolo, M. Marosi, J. Mazzitelli, S. Latifi, Y. Sano, L. Galvan, R. Kawaguchi, S. Holley, M. S. Levine, G. Coppola, C. Portera-Cailliau, A. J. Silva, S. T. Carmichael
Format:	article
Language:	EN
Published:	Nature Portfolio 2018
Subjects:	Science Q
Online Access:	https://doaj.org/article/05a9e7aafa6841b9af624741d45f7321
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spelling	oai:doaj.org-article:05a9e7aafa6841b9af624741d45f73212021-12-02T14:39:06ZCREB controls cortical circuit plasticity and functional recovery after stroke10.1038/s41467-018-04445-92041-1723https://doaj.org/article/05a9e7aafa6841b9af624741d45f73212018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04445-9https://doaj.org/toc/2041-1723Increasing excitability in the peri-infarct area enhances motor recovery after stroke. Here the authors show that expressing CREB, a transcription factor known for its role in synaptic plasticity, or increasing activity of CREB-expressing cells near the stroke site improves recovery in an effect that is strong enough that it can be used to turn on and off motor recovery after stroke.L. CaraccioloM. MarosiJ. MazzitelliS. LatifiY. SanoL. GalvanR. KawaguchiS. HolleyM. S. LevineG. CoppolaC. Portera-CailliauA. J. SilvaS. T. CarmichaelNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q L. Caracciolo M. Marosi J. Mazzitelli S. Latifi Y. Sano L. Galvan R. Kawaguchi S. Holley M. S. Levine G. Coppola C. Portera-Cailliau A. J. Silva S. T. Carmichael CREB controls cortical circuit plasticity and functional recovery after stroke
description	Increasing excitability in the peri-infarct area enhances motor recovery after stroke. Here the authors show that expressing CREB, a transcription factor known for its role in synaptic plasticity, or increasing activity of CREB-expressing cells near the stroke site improves recovery in an effect that is strong enough that it can be used to turn on and off motor recovery after stroke.
format	article
author	L. Caracciolo M. Marosi J. Mazzitelli S. Latifi Y. Sano L. Galvan R. Kawaguchi S. Holley M. S. Levine G. Coppola C. Portera-Cailliau A. J. Silva S. T. Carmichael
author_facet	L. Caracciolo M. Marosi J. Mazzitelli S. Latifi Y. Sano L. Galvan R. Kawaguchi S. Holley M. S. Levine G. Coppola C. Portera-Cailliau A. J. Silva S. T. Carmichael
author_sort	L. Caracciolo
title	CREB controls cortical circuit plasticity and functional recovery after stroke
title_short	CREB controls cortical circuit plasticity and functional recovery after stroke
title_full	CREB controls cortical circuit plasticity and functional recovery after stroke
title_fullStr	CREB controls cortical circuit plasticity and functional recovery after stroke
title_full_unstemmed	CREB controls cortical circuit plasticity and functional recovery after stroke
title_sort	creb controls cortical circuit plasticity and functional recovery after stroke
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/05a9e7aafa6841b9af624741d45f7321
work_keys_str_mv	AT lcaracciolo crebcontrolscorticalcircuitplasticityandfunctionalrecoveryafterstroke AT mmarosi crebcontrolscorticalcircuitplasticityandfunctionalrecoveryafterstroke AT jmazzitelli crebcontrolscorticalcircuitplasticityandfunctionalrecoveryafterstroke AT slatifi crebcontrolscorticalcircuitplasticityandfunctionalrecoveryafterstroke AT ysano crebcontrolscorticalcircuitplasticityandfunctionalrecoveryafterstroke AT lgalvan crebcontrolscorticalcircuitplasticityandfunctionalrecoveryafterstroke AT rkawaguchi crebcontrolscorticalcircuitplasticityandfunctionalrecoveryafterstroke AT sholley crebcontrolscorticalcircuitplasticityandfunctionalrecoveryafterstroke AT mslevine crebcontrolscorticalcircuitplasticityandfunctionalrecoveryafterstroke AT gcoppola crebcontrolscorticalcircuitplasticityandfunctionalrecoveryafterstroke AT cporteracailliau crebcontrolscorticalcircuitplasticityandfunctionalrecoveryafterstroke AT ajsilva crebcontrolscorticalcircuitplasticityandfunctionalrecoveryafterstroke AT stcarmichael crebcontrolscorticalcircuitplasticityandfunctionalrecoveryafterstroke
_version_	1718390694085656576

CREB controls cortical circuit plasticity and functional recovery after stroke

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