Treating Lennox–Gastaut syndrome in epileptic pediatric patients with third-generation rufinamide
Jessica Gresham1, Lea S Eiland2,3, Allison M Chung2,41Auburn University, Harrison School of Pharmacy (AUHSOP), 2Department of Pharmacy Practice, AUHSOP, 3University of Alabama, School of Medicine, Huntsville Regional Medical Campus, 4University of South Alabama School of Medicine, Department of Pedi...
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Dove Medical Press
2010
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oai:doaj.org-article:05aa3bf17ca446ef83e9a117b43950412021-12-02T06:45:05ZTreating Lennox–Gastaut syndrome in epileptic pediatric patients with third-generation rufinamide1176-63281178-2021https://doaj.org/article/05aa3bf17ca446ef83e9a117b43950412010-09-01T00:00:00Zhttp://www.dovepress.com/treating-lennoxndashgastaut-syndrome-in-epileptic-pediatric-patients-w-a5352https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Jessica Gresham1, Lea S Eiland2,3, Allison M Chung2,41Auburn University, Harrison School of Pharmacy (AUHSOP), 2Department of Pharmacy Practice, AUHSOP, 3University of Alabama, School of Medicine, Huntsville Regional Medical Campus, 4University of South Alabama School of Medicine, Department of Pediatrics, Mobile, Alabama, USAAbstract: Lennox–Gastaut syndrome (LGS) is a rare but debilitating pediatric epileptic encephalopathy characterized by multiple intractable seizure types. Treatment of LGS is challenging because of the small number of antiepileptic drugs (AEDs) which are effective for this syndrome, as well as the need for polytherapy in the majority of patients. This review focuses on the treatment of LGS with rufinamide, a recently approved third-generation AED with reported efficacy as adjunctive therapy for LGS. All relevant papers identified through a PubMed search on the treatment of LGS with rufinamide were reviewed. To date, the literature suggests improvements in seizure frequency for pediatric patients with LGS on rufinamide. Rufinamide appears to be especially effective for atonic or drop attack seizures. Rufinamide also displays a favorable adverse event profile compared with the older anticonvulsants, as well as a minimal number of drug interactions, making it a promising option for the adjunctive treatment of seizures associated with LGS.Keywords: epilepsy, Lennox-Gastaut syndrome, pediatrics, seizure, rufinamide Jessica GreshamLea S EilandAllison M ChungDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2010, Iss Issue 1, Pp 639-645 (2010) |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Jessica Gresham Lea S Eiland Allison M Chung Treating Lennox–Gastaut syndrome in epileptic pediatric patients with third-generation rufinamide |
| description |
Jessica Gresham1, Lea S Eiland2,3, Allison M Chung2,41Auburn University, Harrison School of Pharmacy (AUHSOP), 2Department of Pharmacy Practice, AUHSOP, 3University of Alabama, School of Medicine, Huntsville Regional Medical Campus, 4University of South Alabama School of Medicine, Department of Pediatrics, Mobile, Alabama, USAAbstract: Lennox–Gastaut syndrome (LGS) is a rare but debilitating pediatric epileptic encephalopathy characterized by multiple intractable seizure types. Treatment of LGS is challenging because of the small number of antiepileptic drugs (AEDs) which are effective for this syndrome, as well as the need for polytherapy in the majority of patients. This review focuses on the treatment of LGS with rufinamide, a recently approved third-generation AED with reported efficacy as adjunctive therapy for LGS. All relevant papers identified through a PubMed search on the treatment of LGS with rufinamide were reviewed. To date, the literature suggests improvements in seizure frequency for pediatric patients with LGS on rufinamide. Rufinamide appears to be especially effective for atonic or drop attack seizures. Rufinamide also displays a favorable adverse event profile compared with the older anticonvulsants, as well as a minimal number of drug interactions, making it a promising option for the adjunctive treatment of seizures associated with LGS.Keywords: epilepsy, Lennox-Gastaut syndrome, pediatrics, seizure, rufinamide |
| format |
article |
| author |
Jessica Gresham Lea S Eiland Allison M Chung |
| author_facet |
Jessica Gresham Lea S Eiland Allison M Chung |
| author_sort |
Jessica Gresham |
| title |
Treating Lennox–Gastaut syndrome in epileptic pediatric patients with third-generation rufinamide |
| title_short |
Treating Lennox–Gastaut syndrome in epileptic pediatric patients with third-generation rufinamide |
| title_full |
Treating Lennox–Gastaut syndrome in epileptic pediatric patients with third-generation rufinamide |
| title_fullStr |
Treating Lennox–Gastaut syndrome in epileptic pediatric patients with third-generation rufinamide |
| title_full_unstemmed |
Treating Lennox–Gastaut syndrome in epileptic pediatric patients with third-generation rufinamide |
| title_sort |
treating lennox–gastaut syndrome in epileptic pediatric patients with third-generation rufinamide |
| publisher |
Dove Medical Press |
| publishDate |
2010 |
| url |
https://doaj.org/article/05aa3bf17ca446ef83e9a117b4395041 |
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