RESPONSE OF LYMPHOID CELLS TO REGULATORY SIGNAL OF INTERLEUKIN 1 AS AN INDEX OF LYMPHOCYTE ACTIVITY

Intensivity of lymphocyte proliferative activity is an important and almost the only indicator of the level of functional activity of these cells, and the immune system in general. The aim of this study was to develop an adequate physiological test to determine the degree of functional activity of l...

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Autores principales:	S. N. Shanin, E. A. Korneva
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2019
Materias:	lymphocyte proliferation il-1 stress injury meningitis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/05ad3ef2ff35451b822435ff8c540e5c
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spelling	oai:doaj.org-article:05ad3ef2ff35451b822435ff8c540e5c2021-11-18T08:03:48ZRESPONSE OF LYMPHOID CELLS TO REGULATORY SIGNAL OF INTERLEUKIN 1 AS AN INDEX OF LYMPHOCYTE ACTIVITY1563-06252313-741X10.15789/1563-0625-2019-4-661-668https://doaj.org/article/05ad3ef2ff35451b822435ff8c540e5c2019-10-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1726https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XIntensivity of lymphocyte proliferative activity is an important and almost the only indicator of the level of functional activity of these cells, and the immune system in general. The aim of this study was to develop an adequate physiological test to determine the degree of functional activity of lymphoid cells. The choice of IL-1 as an activator of proliferation is justified by the presence of receptors to IL-1 on lymphoid cell membranes, the key role of this cytokine in the initiation of a wide range of biological effects of the immune system to antigen, including participation in intercellular cooperation and distant action on various cells. It was found that the ligand-receptor interaction of IL-1 by type I receptor activates neutral sphingomyelinase, and the sphingomyelin pathway of signal transduction in lymphocytes. The degree of activation of this enzyme depends on the type of stress and correlates with changes of the vector of humoral immune response and proliferative activity of lymphocytes. The level of IL-1 increases, but the activity of neutral sphingomyelinase and lymphoid cell proliferation is significantly reduced after applications of immunosuppressive stress in mice and rats. The change of the degree of lymphocyte proliferation has become a marker of the severity of the pathological process in clinic. A high degree of correlation between the low intensity of peripheral blood lymphocyte proliferation in response to IL-1 action and the unfavorable disease outcome in patients with severe combined trauma and children with purulent meningitis was established. Thus, the degree of lymphocyte proliferation in response to the action of the regulatory signal of IL-1 can be used both for the analysis of the effectiveness of immunomodulators, and as diagnostic and prognostic indicator in clinical practice.S. N. ShaninE. A. KornevaSPb RAACIarticlelymphocyte proliferationil-1stressinjurymeningitisImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 21, Iss 4, Pp 661-668 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	lymphocyte proliferation il-1 stress injury meningitis Immunologic diseases. Allergy RC581-607
spellingShingle	lymphocyte proliferation il-1 stress injury meningitis Immunologic diseases. Allergy RC581-607 S. N. Shanin E. A. Korneva RESPONSE OF LYMPHOID CELLS TO REGULATORY SIGNAL OF INTERLEUKIN 1 AS AN INDEX OF LYMPHOCYTE ACTIVITY
description	Intensivity of lymphocyte proliferative activity is an important and almost the only indicator of the level of functional activity of these cells, and the immune system in general. The aim of this study was to develop an adequate physiological test to determine the degree of functional activity of lymphoid cells. The choice of IL-1 as an activator of proliferation is justified by the presence of receptors to IL-1 on lymphoid cell membranes, the key role of this cytokine in the initiation of a wide range of biological effects of the immune system to antigen, including participation in intercellular cooperation and distant action on various cells. It was found that the ligand-receptor interaction of IL-1 by type I receptor activates neutral sphingomyelinase, and the sphingomyelin pathway of signal transduction in lymphocytes. The degree of activation of this enzyme depends on the type of stress and correlates with changes of the vector of humoral immune response and proliferative activity of lymphocytes. The level of IL-1 increases, but the activity of neutral sphingomyelinase and lymphoid cell proliferation is significantly reduced after applications of immunosuppressive stress in mice and rats. The change of the degree of lymphocyte proliferation has become a marker of the severity of the pathological process in clinic. A high degree of correlation between the low intensity of peripheral blood lymphocyte proliferation in response to IL-1 action and the unfavorable disease outcome in patients with severe combined trauma and children with purulent meningitis was established. Thus, the degree of lymphocyte proliferation in response to the action of the regulatory signal of IL-1 can be used both for the analysis of the effectiveness of immunomodulators, and as diagnostic and prognostic indicator in clinical practice.
format	article
author	S. N. Shanin E. A. Korneva
author_facet	S. N. Shanin E. A. Korneva
author_sort	S. N. Shanin
title	RESPONSE OF LYMPHOID CELLS TO REGULATORY SIGNAL OF INTERLEUKIN 1 AS AN INDEX OF LYMPHOCYTE ACTIVITY
title_short	RESPONSE OF LYMPHOID CELLS TO REGULATORY SIGNAL OF INTERLEUKIN 1 AS AN INDEX OF LYMPHOCYTE ACTIVITY
title_full	RESPONSE OF LYMPHOID CELLS TO REGULATORY SIGNAL OF INTERLEUKIN 1 AS AN INDEX OF LYMPHOCYTE ACTIVITY
title_fullStr	RESPONSE OF LYMPHOID CELLS TO REGULATORY SIGNAL OF INTERLEUKIN 1 AS AN INDEX OF LYMPHOCYTE ACTIVITY
title_full_unstemmed	RESPONSE OF LYMPHOID CELLS TO REGULATORY SIGNAL OF INTERLEUKIN 1 AS AN INDEX OF LYMPHOCYTE ACTIVITY
title_sort	response of lymphoid cells to regulatory signal of interleukin 1 as an index of lymphocyte activity
publisher	SPb RAACI
publishDate	2019
url	https://doaj.org/article/05ad3ef2ff35451b822435ff8c540e5c
work_keys_str_mv	AT snshanin responseoflymphoidcellstoregulatorysignalofinterleukin1asanindexoflymphocyteactivity AT eakorneva responseoflymphoidcellstoregulatorysignalofinterleukin1asanindexoflymphocyteactivity
_version_	1718422331567636480

RESPONSE OF LYMPHOID CELLS TO REGULATORY SIGNAL OF INTERLEUKIN 1 AS AN INDEX OF LYMPHOCYTE ACTIVITY

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