Light-stimulus intensity modulates startle reflex habituation in larval zebrafish

Abstract The startle reflex in larval zebrafish describes a C-bend of the body occurring in response to sudden, unexpected, stimuli of different sensory modalities. Alterations in the startle reflex habituation (SRH) have been reported in various human and animal models of neurological and psychiatr...

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Autores principales:	Carolina Beppi, Giorgio Beringer, Dominik Straumann, Stefan Yu Bögli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/05aea555c2c747efa45fed25eee0f8e9
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spelling	oai:doaj.org-article:05aea555c2c747efa45fed25eee0f8e92021-11-21T12:18:14ZLight-stimulus intensity modulates startle reflex habituation in larval zebrafish10.1038/s41598-021-00535-92045-2322https://doaj.org/article/05aea555c2c747efa45fed25eee0f8e92021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-00535-9https://doaj.org/toc/2045-2322Abstract The startle reflex in larval zebrafish describes a C-bend of the body occurring in response to sudden, unexpected, stimuli of different sensory modalities. Alterations in the startle reflex habituation (SRH) have been reported in various human and animal models of neurological and psychiatric conditions and are hence considered an important behavioural marker of neurophysiological function. The amplitude, offset and decay constant of the auditory SRH in larval zebrafish have recently been characterised, revealing that the measures are affected by variation in vibratory frequency, intensity, and interstimulus-interval. Currently, no study provides a model-based analysis of the effect of physical properties of light stimuli on the visual SRH. This study assessed the effect of incremental light-stimulus intensity on the SRH of larval zebrafish through a repeated-measures design. Their total locomotor responses were normalised for the time factor, based on the behaviour of a (non-stimulated) control group. A linear regression indicated that light intensity positively predicts locomotor responses due to larger SRH decay constants and offsets. The conclusions of this study provide important insights as to the effect of light properties on the SRH in larval zebrafish. Our methodology and findings constitute a relevant reference framework for further investigation in translational neurophysiological research.Carolina BeppiGiorgio BeringerDominik StraumannStefan Yu BögliNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Carolina Beppi Giorgio Beringer Dominik Straumann Stefan Yu Bögli Light-stimulus intensity modulates startle reflex habituation in larval zebrafish
description	Abstract The startle reflex in larval zebrafish describes a C-bend of the body occurring in response to sudden, unexpected, stimuli of different sensory modalities. Alterations in the startle reflex habituation (SRH) have been reported in various human and animal models of neurological and psychiatric conditions and are hence considered an important behavioural marker of neurophysiological function. The amplitude, offset and decay constant of the auditory SRH in larval zebrafish have recently been characterised, revealing that the measures are affected by variation in vibratory frequency, intensity, and interstimulus-interval. Currently, no study provides a model-based analysis of the effect of physical properties of light stimuli on the visual SRH. This study assessed the effect of incremental light-stimulus intensity on the SRH of larval zebrafish through a repeated-measures design. Their total locomotor responses were normalised for the time factor, based on the behaviour of a (non-stimulated) control group. A linear regression indicated that light intensity positively predicts locomotor responses due to larger SRH decay constants and offsets. The conclusions of this study provide important insights as to the effect of light properties on the SRH in larval zebrafish. Our methodology and findings constitute a relevant reference framework for further investigation in translational neurophysiological research.
format	article
author	Carolina Beppi Giorgio Beringer Dominik Straumann Stefan Yu Bögli
author_facet	Carolina Beppi Giorgio Beringer Dominik Straumann Stefan Yu Bögli
author_sort	Carolina Beppi
title	Light-stimulus intensity modulates startle reflex habituation in larval zebrafish
title_short	Light-stimulus intensity modulates startle reflex habituation in larval zebrafish
title_full	Light-stimulus intensity modulates startle reflex habituation in larval zebrafish
title_fullStr	Light-stimulus intensity modulates startle reflex habituation in larval zebrafish
title_full_unstemmed	Light-stimulus intensity modulates startle reflex habituation in larval zebrafish
title_sort	light-stimulus intensity modulates startle reflex habituation in larval zebrafish
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/05aea555c2c747efa45fed25eee0f8e9
work_keys_str_mv	AT carolinabeppi lightstimulusintensitymodulatesstartlereflexhabituationinlarvalzebrafish AT giorgioberinger lightstimulusintensitymodulatesstartlereflexhabituationinlarvalzebrafish AT dominikstraumann lightstimulusintensitymodulatesstartlereflexhabituationinlarvalzebrafish AT stefanyubogli lightstimulusintensitymodulatesstartlereflexhabituationinlarvalzebrafish
_version_	1718419044647829504

Light-stimulus intensity modulates startle reflex habituation in larval zebrafish

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