Prognostic impact of microsatellite instability in gastric cancer

Gastric cancer is a common and deadly cancer. Several factors are associated with its prognosis; however, controversy exists about the role of microsatellite instability (MSI). We aimed to determine the 5-year overall survival (OS) of MSI in gastric adenocarcinoma. A cross-sectional study was carr...

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Autores principales:	Cesar Zepeda-Najar, Rodrigo Xavier Palacios-Astudillo, Jazmín Danaé Chávez-Hernández, Leonardo Saul Lino-Silva, Rosa A. Salcedo-Hernández
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2021
Materias:	gastric cancer microsatellite instability immunohistochemistry cancer prognosis overall survival. Medicine R
Acceso en línea:	https://doaj.org/article/05af754bc6b742cab397fa07a56efae7
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spelling	oai:doaj.org-article:05af754bc6b742cab397fa07a56efae72021-12-02T17:18:57ZPrognostic impact of microsatellite instability in gastric cancer1428-25261897-430910.5114/wo.2021.104939https://doaj.org/article/05af754bc6b742cab397fa07a56efae72021-03-01T00:00:00Zhttps://www.termedia.pl/Prognostic-impact-of-microsatellite-instability-in-gastric-cancer,3,43693,1,1.htmlhttps://doaj.org/toc/1428-2526https://doaj.org/toc/1897-4309Gastric cancer is a common and deadly cancer. Several factors are associated with its prognosis; however, controversy exists about the role of microsatellite instability (MSI). We aimed to determine the 5-year overall survival (OS) of MSI in gastric adenocarcinoma. A cross-sectional study was carried out on gastric adenocarcinoma in clinical stages I to III treated with D2 gastrectomy between 2010–2013. MSI was demonstrated by immunohistochemistry. We performed a survival analysis comparing cases with and without MSI. From 102 cases, 9.8% showed MSI. The median age was 63 years (range 33–91 years), and 57.8% were men. The more prevalent site of occurrence was the antrum (46.1%), 78.5% of the cases presented in stage III, 47.1% were of the diffuse type, 45.1% were of an intestinal type, and 7.8% were mixed. MSI cases were associated with lower clinical stages (stages I–II) and with better 5-year OS (100 vs. 47 months, p = 0.017). In a multivariate analysis, MSI was independently associated with better survival (HR = 0.209, 95% CI: 0.046–0.945, p = 0.042). MSI gastric cancers presented in early clinical stages and had favourable prognosis compared with non-MSI cancers.Cesar Zepeda-NajarRodrigo Xavier Palacios-AstudilloJazmín Danaé Chávez-HernándezLeonardo Saul Lino-SilvaRosa A. Salcedo-HernándezTermedia Publishing Housearticlegastric cancer microsatellite instability immunohistochemistry cancer prognosis overall survival.MedicineRENContemporary Oncology, Vol 25, Iss 1, Pp 68-71 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	gastric cancer microsatellite instability immunohistochemistry cancer prognosis overall survival. Medicine R
spellingShingle	gastric cancer microsatellite instability immunohistochemistry cancer prognosis overall survival. Medicine R Cesar Zepeda-Najar Rodrigo Xavier Palacios-Astudillo Jazmín Danaé Chávez-Hernández Leonardo Saul Lino-Silva Rosa A. Salcedo-Hernández Prognostic impact of microsatellite instability in gastric cancer
description	Gastric cancer is a common and deadly cancer. Several factors are associated with its prognosis; however, controversy exists about the role of microsatellite instability (MSI). We aimed to determine the 5-year overall survival (OS) of MSI in gastric adenocarcinoma. A cross-sectional study was carried out on gastric adenocarcinoma in clinical stages I to III treated with D2 gastrectomy between 2010–2013. MSI was demonstrated by immunohistochemistry. We performed a survival analysis comparing cases with and without MSI. From 102 cases, 9.8% showed MSI. The median age was 63 years (range 33–91 years), and 57.8% were men. The more prevalent site of occurrence was the antrum (46.1%), 78.5% of the cases presented in stage III, 47.1% were of the diffuse type, 45.1% were of an intestinal type, and 7.8% were mixed. MSI cases were associated with lower clinical stages (stages I–II) and with better 5-year OS (100 vs. 47 months, p = 0.017). In a multivariate analysis, MSI was independently associated with better survival (HR = 0.209, 95% CI: 0.046–0.945, p = 0.042). MSI gastric cancers presented in early clinical stages and had favourable prognosis compared with non-MSI cancers.
format	article
author	Cesar Zepeda-Najar Rodrigo Xavier Palacios-Astudillo Jazmín Danaé Chávez-Hernández Leonardo Saul Lino-Silva Rosa A. Salcedo-Hernández
author_facet	Cesar Zepeda-Najar Rodrigo Xavier Palacios-Astudillo Jazmín Danaé Chávez-Hernández Leonardo Saul Lino-Silva Rosa A. Salcedo-Hernández
author_sort	Cesar Zepeda-Najar
title	Prognostic impact of microsatellite instability in gastric cancer
title_short	Prognostic impact of microsatellite instability in gastric cancer
title_full	Prognostic impact of microsatellite instability in gastric cancer
title_fullStr	Prognostic impact of microsatellite instability in gastric cancer
title_full_unstemmed	Prognostic impact of microsatellite instability in gastric cancer
title_sort	prognostic impact of microsatellite instability in gastric cancer
publisher	Termedia Publishing House
publishDate	2021
url	https://doaj.org/article/05af754bc6b742cab397fa07a56efae7
work_keys_str_mv	AT cesarzepedanajar prognosticimpactofmicrosatelliteinstabilityingastriccancer AT rodrigoxavierpalaciosastudillo prognosticimpactofmicrosatelliteinstabilityingastriccancer AT jazmindanaechavezhernandez prognosticimpactofmicrosatelliteinstabilityingastriccancer AT leonardosaullinosilva prognosticimpactofmicrosatelliteinstabilityingastriccancer AT rosaasalcedohernandez prognosticimpactofmicrosatelliteinstabilityingastriccancer
_version_	1718381064265662464

Prognostic impact of microsatellite instability in gastric cancer

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